Extracellular Vesicles as Mediators of Endothelial Dysfunction in Cardiovascular Diseases
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1008 - 1008
Опубликована: Янв. 24, 2025
This
comprehensive
review
aims
to
provide
a
thorough
overview
of
the
vital
role
that
extracellular
vesicles
(EVs)
play
in
endothelial
dysfunction,
particularly
emphasizing
how
physiological
factors—such
as
sex
and
aging—along
with
significant
cardiovascular
risk
factors,
influence
this
process.
The
covers
studies
ranging
from
first
description
EVs
1945
contemporary
insights
into
their
biological
roles
intercellular
signaling
dysfunction.
A
analysis
peer-reviewed
articles
reviews
indexed
PubMed
database
was
conducted
compile
information.
Initially,
Medical
Subject
Headings
(MeSH)
terms
included
keywords
aimed
at
providing
general
knowledge
about
regulation
signaling,
such
“extracellular
vesicles”,
“endothelium”,
“intercellular
signaling”.
Subsequently,
related
pathophysiological
implications
EV
interactions
dysfunction
disease
were
added,
including
“cardiovascular
disease”,
“sex”,
“aging”,
“atherosclerosis”,
“obesity”,
“diabetes”.
Additionally,
potential
applications
explored
using
MeSH
“biomarker”,
“therapeutic
strategy”.
results
bibliographical
reveal
have
capacity
induce
various
cellular
responses
within
system
complex
landscape
disease.
composition
cargo
is
subject
modification
by
conditions
sex,
aging,
which
result
regulatory
on
function
neighboring
cells
when
released
dysfunctional
endothelium.
Moreover,
data
suggest
field
still
requires
further
exploration,
biology
continuously
evolving,
presenting
dynamic
engaging
area
for
research.
deeper
understanding
molecular
involved
EV–endothelium
could
yield
valuable
biomarkers
monitoring
progression
facilitate
development
innovative
bioengineered
therapeutic
strategies
enhance
patient
outcomes.
Язык: Английский
Targeted Tumor Delivery Using Extracellular Vesicles
Methods in pharmacology and toxicology,
Год журнала:
2025,
Номер
unknown, С. 125 - 153
Опубликована: Янв. 1, 2025
Язык: Английский
Extracellular vesicles and microRNAs in cancer progression
Advances in clinical chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Differential protein and mRNA cargo loading into engineered large and small extracellular vesicles reveals differences in in vitro and in vivo assays
Journal of Controlled Release,
Год журнала:
2025,
Номер
379, С. 951 - 966
Опубликована: Фев. 3, 2025
Язык: Английский
Extracellular vesicle-mediated chemoresistance in breast cancer: focus on miRNA cargo
Extracellular Vesicles and Circulating Nucleic Acids,
Год журнала:
2025,
Номер
6(1), С. 112 - 27
Опубликована: Фев. 24, 2025
The
role
of
extracellular
vesicles
(EVs)
in
mediating
chemoresistance
has
gained
significant
attention
due
to
their
ability
transfer
bioactive
molecules
between
drug-resistant
and
drug-sensitive
cells.
In
particular,
they
have
been
demonstrated
play
an
active
part
breast
cancer
by
the
horizontal
genetic
protein
material.
This
review
highlights
EVs,
particularly
miRNA
cargo,
driving
drug
resistance
cancer.
EVs
derived
from
chemoresistant
cells
carry
miRNAs
lncRNAs,
which
are
known
modulate
gene
networks
involved
cell
proliferation
survival.
These
cargo
suppress
apoptosis
targeting
pro-apoptotic
genes
like
PTEN
BIM,
promote
epithelial-mesenchymal
transition
(EMT)
through
regulation
pathways
such
as
TGF-β
Wnt/b-catenin,
contribute
tumor
growth
enhancing
angiogenesis
modulating
microenvironment.
Beyond
RNA-mediated
effects,
also
functional
proteins,
including
P-glycoprotein
Hsp70,
impact
cellular
metabolism
survival
pathways.
Our
findings
underscore
significance
chemoresistance,
suggesting
potential
involvement
possible
prognostic
factors
predict
therapy
response
therapeutic
targets
combination
with
usual
therapy.
Язык: Английский
Extracellular vesicles for the delivery of gene therapy
Nature Reviews Bioengineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Язык: Английский
Harnessing Extracellular Vesicles for Targeted Drug Delivery in Ovarian Cancer
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 528 - 528
Опубликована: Апрель 17, 2025
Ovarian
cancer
remains
one
of
the
most
lethal
gynecologic
malignancies,
primarily
due
to
late-stage
diagnosis,
high
recurrence
rates,
and
development
chemoresistance.
Although
targeted
therapies
have
improved
patient
outcomes,
their
efficacy
is
often
limited
by
off-target
toxicity
acquired
drug
resistance.
Extracellular
vesicles
(EVs),
nanoscale
naturally
released
cells,
emerged
as
promising
carriers
for
precision
delivery.
This
review
provides
a
comprehensive
overview
recent
advances
in
EV-based
therapeutic
strategies
ovarian
cancer,
including
delivery
chemotherapeutic
agents,
nucleic
acid
therapeutics,
immunomodulatory
molecules.
We
further
explore
innovative
engineering
approaches
enhance
targeting
specificity,
such
surface
modification,
cell
source
selection,
biomaterial
integration,
magnetic
nanoparticle-assisted
Key
translational
challenges
bringing
clinical
application
are
also
addressed.
Collectively,
these
insights
underscore
transformative
potential
platforms
advancing
personalized
treatment
cancer.
Язык: Английский
Extracellular Vesicle lncRNAs as Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers
Non-Coding RNA,
Год журнала:
2024,
Номер
10(6), С. 54 - 54
Опубликована: Ноя. 5, 2024
Extracellular
vesicles
(EVs)
are
secreted
by
almost
every
cell
type
and
considered
carriers
of
active
biomolecules,
such
as
nucleic
acids,
proteins,
lipids.
Their
content
can
be
uptaken
released
into
the
cytoplasm
recipient
cells,
thereby
inducing
gene
reprogramming
phenotypic
changes
in
acceptor
cells.
Whether
effects
EVs
on
physiology
cells
mediated
individual
biomolecules
or
collective
outcome
total
transferred
EV
is
still
under
debate.
The
RNA
consists
several
types
RNA,
messenger
(mRNA),
microRNA
(miRNA),
long
non-coding
(lncRNA),
latter
defined
transcripts
longer
than
200
nucleotides
that
do
not
code
for
proteins
but
have
important
established
biological
functions.
This
review
aims
to
update
our
insights
functional
roles
their
cargo
during
cancer
progression,
highlight
utility
novel
diagnostic
prognostic
biomarkers
cancer,
tackle
technological
advances
limitations
identification,
integrity
assessment,
preservation
its
functionality.
Язык: Английский
Gold Kiwi-Derived Nanovesicles Mitigate Ultraviolet-Induced Photoaging and Enhance Osteogenic Differentiation in Bone Marrow Mesenchymal Stem Cells
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1474 - 1474
Опубликована: Ноя. 29, 2024
Bone
marrow
mesenchymal
stem
cells
(BM-MSCs)
play
a
crucial
role
in
bone
formation
through
their
ability
to
differentiate
into
osteoblasts.
Aging,
however,
detrimentally
affects
the
differentiation
and
proliferation
capacities
of
BM-MSCs,
consequently
impairing
regeneration.
Thus,
mitigating
aging
effects
on
BM-MSCs
is
vital
for
addressing
bone-related
pathologies.
In
this
study,
we
demonstrate
that
extracellular
nanovesicles
isolated
from
gold
kiwi
(GK-NVs)
protect
human
ultraviolet
(UV)-induced
photoaging,
thereby
alleviating
aging-related
impairments
cellular
functions
are
homeostasis.
Notably,
GK-NVs
were
efficiently
taken
up
by
without
causing
cytotoxicity.
reduced
intracellular
reactive
oxygen
species
(ROS)
levels
upon
UV
irradiation,
restoring
impaired
migration
capabilities.
Furthermore,
corrected
skewed
UV-irradiated
enhancing
osteoblast
differentiation,
as
evidenced
increased
expression
osteoblast-specific
genes
calcium
deposition,
reducing
adipocyte
indicated
decreased
lipid
droplet
formation.
These
findings
position
promising
biomaterial
treatment
diseases
such
osteoporosis.
Язык: Английский