Extracellular Vesicle lncRNAs as Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers DOI Creative Commons
Panagiotis Papoutsoglou, Antonin Morillon

Non-Coding RNA, Journal Year: 2024, Volume and Issue: 10(6), P. 54 - 54

Published: Nov. 5, 2024

Extracellular vesicles (EVs) are secreted by almost every cell type and considered carriers of active biomolecules, such as nucleic acids, proteins, lipids. Their content can be uptaken released into the cytoplasm recipient cells, thereby inducing gene reprogramming phenotypic changes in acceptor cells. Whether effects EVs on physiology cells mediated individual biomolecules or collective outcome total transferred EV is still under debate. The RNA consists several types RNA, messenger (mRNA), microRNA (miRNA), long non-coding (lncRNA), latter defined transcripts longer than 200 nucleotides that do not code for proteins but have important established biological functions. This review aims to update our insights functional roles their cargo during cancer progression, highlight utility novel diagnostic prognostic biomarkers cancer, tackle technological advances limitations identification, integrity assessment, preservation its functionality.

Language: Английский

Extracellular Vesicles as Mediators of Endothelial Dysfunction in Cardiovascular Diseases DOI Open Access
Francisco Rafael Jiménez-Trinidad,

Sergi Calvo-Gomez,

Manel Sabaté

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1008 - 1008

Published: Jan. 24, 2025

This comprehensive review aims to provide a thorough overview of the vital role that extracellular vesicles (EVs) play in endothelial dysfunction, particularly emphasizing how physiological factors—such as sex and aging—along with significant cardiovascular risk factors, influence this process. The covers studies ranging from first description EVs 1945 contemporary insights into their biological roles intercellular signaling dysfunction. A analysis peer-reviewed articles reviews indexed PubMed database was conducted compile information. Initially, Medical Subject Headings (MeSH) terms included keywords aimed at providing general knowledge about regulation signaling, such “extracellular vesicles”, “endothelium”, “intercellular signaling”. Subsequently, related pathophysiological implications EV interactions dysfunction disease were added, including “cardiovascular disease”, “sex”, “aging”, “atherosclerosis”, “obesity”, “diabetes”. Additionally, potential applications explored using MeSH “biomarker”, “therapeutic strategy”. results bibliographical reveal have capacity induce various cellular responses within system complex landscape disease. composition cargo is subject modification by conditions sex, aging, which result regulatory on function neighboring cells when released dysfunctional endothelium. Moreover, data suggest field still requires further exploration, biology continuously evolving, presenting dynamic engaging area for research. deeper understanding molecular involved EV–endothelium could yield valuable biomarkers monitoring progression facilitate development innovative bioengineered therapeutic strategies enhance patient outcomes.

Language: Английский

Citations

3
Targeted Tumor Delivery Using Extracellular Vesicles DOI

Hema Saranya Ilamathi,

Samir EL Andaloussi, Oscar P. B. Wiklander

et al.

Methods in pharmacology and toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 125 - 153

Published: Jan. 1, 2025

Language: Английский

Citations

1
Extracellular vesicles and microRNAs in cancer progression DOI
Nicola Salvatore Orefice, Gianluca Petrillo,

Claudia Pignataro

et al.

Advances in clinical chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Extracellular vesicle-mediated chemoresistance in breast cancer: focus on miRNA cargo DOI Open Access
Maria Chiara Ciferri, Roberta Tasso

Extracellular Vesicles and Circulating Nucleic Acids, Journal Year: 2025, Volume and Issue: 6(1), P. 112 - 27

Published: Feb. 24, 2025

The role of extracellular vesicles (EVs) in mediating chemoresistance has gained significant attention due to their ability transfer bioactive molecules between drug-resistant and drug-sensitive cells. In particular, they have been demonstrated play an active part breast cancer by the horizontal genetic protein material. This review highlights EVs, particularly miRNA cargo, driving drug resistance cancer. EVs derived from chemoresistant cells carry miRNAs lncRNAs, which are known modulate gene networks involved cell proliferation survival. These cargo suppress apoptosis targeting pro-apoptotic genes like PTEN BIM, promote epithelial-mesenchymal transition (EMT) through regulation pathways such as TGF-β Wnt/b-catenin, contribute tumor growth enhancing angiogenesis modulating microenvironment. Beyond RNA-mediated effects, also functional proteins, including P-glycoprotein Hsp70, impact cellular metabolism survival pathways. Our findings underscore significance chemoresistance, suggesting potential involvement possible prognostic factors predict therapy response therapeutic targets combination with usual therapy.

Language: Английский

Citations

0
Harnessing Extracellular Vesicles for Targeted Drug Delivery in Ovarian Cancer DOI Creative Commons
Jang‐Hyuk Yun,

Yoo Rim Noh,

Seongkyeong Yoo

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 528 - 528

Published: April 17, 2025

Ovarian cancer remains one of the most lethal gynecologic malignancies, primarily due to late-stage diagnosis, high recurrence rates, and development chemoresistance. Although targeted therapies have improved patient outcomes, their efficacy is often limited by off-target toxicity acquired drug resistance. Extracellular vesicles (EVs), nanoscale naturally released cells, emerged as promising carriers for precision delivery. This review provides a comprehensive overview recent advances in EV-based therapeutic strategies ovarian cancer, including delivery chemotherapeutic agents, nucleic acid therapeutics, immunomodulatory molecules. We further explore innovative engineering approaches enhance targeting specificity, such surface modification, cell source selection, biomaterial integration, magnetic nanoparticle-assisted Key translational challenges bringing clinical application are also addressed. Collectively, these insights underscore transformative potential platforms advancing personalized treatment cancer.

Language: Английский

Citations

0
Differential protein and mRNA cargo loading into engineered large and small extracellular vesicles reveals differences in in vitro and in vivo assays DOI Creative Commons

Zuriñe Erana-Perez,

Manoli Igartúa, Edorta Santos‐Vizcaíno

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 951 - 966

Published: Feb. 3, 2025

Language: Английский

Citations

0
Extracellular vesicles for the delivery of gene therapy DOI
Emilio Di Ianni,

Wataru Obuchi,

Koen Breyne

et al.

Nature Reviews Bioengineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Extracellular vesicles as a promising platform of precision medicine in liver cancer DOI Creative Commons
Keyang Xu, Qibiao Wu, Lingyun Zhao

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107800 - 107800

Published: May 1, 2025

Extracellular vesicles (EVs) are natural carriers of biological information and play pivotal roles in intercellular communication. EVs biocompatible, have low immunogenicity, capable traversing barriers, making them ideal tools for disease diagnosis therapy. Despite their promising prospects, the full realization potential faces several challenges. This article aims to comprehensively review molecular features EVs, applications liver cancer possible underlying mechanisms, critical challenges affecting clinical translation EVs-based therapies cancer.

Language: Английский

Citations

0
Gold Kiwi-Derived Nanovesicles Mitigate Ultraviolet-Induced Photoaging and Enhance Osteogenic Differentiation in Bone Marrow Mesenchymal Stem Cells DOI Creative Commons
Doyeon Kim, Chanho Lee, Manho Kim

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1474 - 1474

Published: Nov. 29, 2024

Bone marrow mesenchymal stem cells (BM-MSCs) play a crucial role in bone formation through their ability to differentiate into osteoblasts. Aging, however, detrimentally affects the differentiation and proliferation capacities of BM-MSCs, consequently impairing regeneration. Thus, mitigating aging effects on BM-MSCs is vital for addressing bone-related pathologies. In this study, we demonstrate that extracellular nanovesicles isolated from gold kiwi (GK-NVs) protect human ultraviolet (UV)-induced photoaging, thereby alleviating aging-related impairments cellular functions are homeostasis. Notably, GK-NVs were efficiently taken up by without causing cytotoxicity. reduced intracellular reactive oxygen species (ROS) levels upon UV irradiation, restoring impaired migration capabilities. Furthermore, corrected skewed UV-irradiated enhancing osteoblast differentiation, as evidenced increased expression osteoblast-specific genes calcium deposition, reducing adipocyte indicated decreased lipid droplet formation. These findings position promising biomaterial treatment diseases such osteoporosis.

Language: Английский

Citations

1
Extracellular Vesicle lncRNAs as Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers DOI Creative Commons
Panagiotis Papoutsoglou, Antonin Morillon

Non-Coding RNA, Journal Year: 2024, Volume and Issue: 10(6), P. 54 - 54

Published: Nov. 5, 2024

Extracellular vesicles (EVs) are secreted by almost every cell type and considered carriers of active biomolecules, such as nucleic acids, proteins, lipids. Their content can be uptaken released into the cytoplasm recipient cells, thereby inducing gene reprogramming phenotypic changes in acceptor cells. Whether effects EVs on physiology cells mediated individual biomolecules or collective outcome total transferred EV is still under debate. The RNA consists several types RNA, messenger (mRNA), microRNA (miRNA), long non-coding (lncRNA), latter defined transcripts longer than 200 nucleotides that do not code for proteins but have important established biological functions. This review aims to update our insights functional roles their cargo during cancer progression, highlight utility novel diagnostic prognostic biomarkers cancer, tackle technological advances limitations identification, integrity assessment, preservation its functionality.

Language: Английский

Citations

0