Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy
Nutrients,
Год журнала:
2024,
Номер
16(21), С. 3741 - 3741
Опубликована: Окт. 31, 2024
Conventional
cancer
treatments
include
surgical
resection,
chemotherapy,
hyperthermia,
immunotherapy,
hormone
therapy,
and
locally
targeted
therapies
such
as
radiation
therapy.
Standard
often
require
the
use
of
multiple
agents,
which
can
activate
nuclear
factor
kappa
B
(NF-κB)
in
tumor
cells,
leading
to
reduced
cell
death
increased
drug
resistance.
Moreover,
agents
also
contributes
added
toxicity,
resulting
poor
treatment
outcomes.
Cancer
cells
gradually
develop
resistance
almost
all
chemotherapeutics
through
various
mechanisms,
efflux,
alterations
metabolism
transport,
changes
signal
transduction
pathways,
enhanced
DNA
repair
capacity,
evasion
apoptosis,
mutations,
reactivation
targets,
interaction
with
microenvironment,
cell-stroma
interactions,
epithelial–mesenchymal
transition
(EMT)-mediated
chemoresistance,
epigenetic
modifications,
metabolic
alterations,
effect
stem
(CSCs).
Developing
new
strategies
improve
chemotherapy
sensitivity
while
minimizing
side
effects
is
essential
for
achieving
better
therapeutic
outcomes
enhancing
patients’
quality
life.
One
promising
approach
involves
combining
conventional
propolis
its
flavonoids.
These
natural
compounds
may
enhance
response
reducing
toxicity.
Propolis
components
sensitize
chemotherapeutic
likely
by
inhibiting
NF-κB
activation,
reprogramming
tumor-associated
macrophages
(TAMs;
an
M2-like
phenotype),
thereby
release
matrix
metalloproteinase
(MMP)-9,
cytokines,
chemokines,
vascular
endothelial
growth
(VEGF).
By
TAMs,
overcome
EMT-mediated
disrupt
crosstalk
between
CSCs,
inhibit
maintenance
stemness,
reverse
acquired
immunosuppression,
thus
promoting
antitumor
mediated
cytotoxic
T-cells.
This
review
highlights
potential
flavonoids
modulate
responsiveness
modalities.
The
evidence
suggests
that
novel
incorporating
could
be
developed
positive
cytotoxicity
peripheral
blood
leukocytes,
liver,
kidney
cells.
Therefore,
polyphenolic/flavonoid
hold
combination
clinical
types
cancers.
Язык: Английский
Luteolin as an adjuvant effectively enhanced the efficacy of adoptive tumor-specific CTLs therapy
BMC Cancer,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 6, 2025
Luteolin,
a
natural
flavonoid
compound,
has
demonstrated
anti-inflammatory,
antioxidant,
and
broad
anti-tumor
properties.
Recent
studies
suggest
that
its
effects
are
linked
to
enhanced
CTL
function-including
proliferation,
survival,
cytotoxicity-via
inhibition
of
the
YAP/Wnt
signaling
pathway
in
tumor
cells.
Consequently,
luteolin
potential
as
an
adjuvant
combination
therapies
with
adoptive
immunotherapy.
This
study
first
assessed
luteolin's
tumor-inhibitory
vitro
vivo
using
cytotoxicity
assays,
Transwell
invasion
tests,
wound
healing
analyses
post-treatment
growth
survival
time.
Additionally,
we
explored
whether
combined
DC/tumor
fusion
vaccine
could
synergistically
enhance
overall
antitumor
efficacy
by
boosting
activation,
cytokines
secretion,
effector
T
Our
findings
indicate
luteolin,
standalone
agent,
can
inhibit
proliferation
colon
lung
cancer
cells
both
certain
extent.
When
activated
CTLs,
it
upregulated
expression
CD25
CD69
resulted
higher
levels
IL-2,
TNF-α,
IFN-γ
secretion
vitro.
In
vivo,
this
significantly
curtailed
subcutaneous
extended
mean
time
tumor-bearing
mice
(HCT116,
A549),
outperforming
monotherapy.
Furthermore,
therapy
may
be
attributable
apoptosis
cells,
reduced
decreased
YAP
expression.
The
vaccine-activated
CTLs
presents
novel
approach
for
treatment.
As
adjuvant,
downregulates
enhancing
cytotoxicity,
thus
improving
recognition
selective
targeting.
strategy
is
promising
safe
effective
Язык: Английский
Breast Cancer Stem Cell Heterogeneity, Plasticity and Treatment Strategies
Опубликована: Март 6, 2025
Breast
cancer
stem
cells
(BCSCs)
are
a
small
proportion
of
stem-like
breast
with
more
tumorigenic
and
metastatic
capacity
in
comparison
to
the
bulk
tumor
cells,
which
capable
self-renewal
generating
differentiated
cells.
BCSCs
resistant
chemotherapy
radiotherapy.
More
research
indicate
that
heterogeneous
have
plasticity,
refer
their
ability
switch
between
different
subtypes
There
is
some
evidence
showing
BCSC
heterogeneity
plasticity
plays
role
on
therapeutic
resistance
metastasis
cancer.
In
this
review,
we
discussed
roles
extrinsic
(rewired
microenvironment,
including
hypoxia,
microbiota)
intrinsic
(pro-tumor
signaling)
factors
regulating
leading
various
malignant
behaviors
BCSCs,
epithelial-mesenchymal
transition
(EMT)/mesenchymal-epithelial
(MET),
immune
evasion,
vasculogenesis
so
on.
Moreover,
also
potential
strategies
target
BCSCs.
Язык: Английский
Unraveling the breast cancer tumor microenvironment: crucial factors influencing natural killer cell function and therapeutic strategies
International Journal of Biological Sciences,
Год журнала:
2025,
Номер
21(6), С. 2606 - 2628
Опубликована: Март 24, 2025
Natural
killer
(NK)
cells
have
emerged
as
a
novel
and
effective
treatment
for
breast
cancer.
Nevertheless,
the
cancer
tumor
microenvironment
(TME)
manifests
multiple
immunosuppressive
mechanisms,
impeding
proper
execution
of
NK
cell
functions.
This
review
summarizes
recent
research
on
influence
TME
functionality
in
It
delves
into
effects
internal
environment
elucidates
roles
diverse
stromal
components,
immune
cells,
signaling
molecules
regulating
activity
within
TME.
also
therapeutic
strategies
based
small-molecule
inhibitors,
antibody
therapies,
natural
products,
well
progress
preclinical
clinical
trials.
By
enhancing
our
understanding
formulating
to
counteract
its
effects,
we
could
fully
harness
promise
treatment.
Язык: Английский
A Compressive Review on Source, Toxicity and Biological Activity of Flavonoid
Current Topics in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(24), С. 2093 - 2116
Опубликована: Авг. 7, 2024
Flavonoids
are
biologically
active
chemicals
in
various
fruits,
plants,
vegetables,
and
leaves,
which
have
promising
uses
medicinal
science.
The
health
properties
of
these
natural
widely
accepted,
efforts
underway
to
extract
the
specific
components
referred
as
flavonoids.
demonstrate
a
diverse
range
bio-activities,
anticancer,
antioxidant
activity,
anti-cholinesterase
antiinflammatory
antimalarial
antidiabetic
neurodegenerative
disease,
cardiovascular
effect,
hepatoprotective
effects,
antiviral
antimicrobial
activity.
This
study
aims
examine
prevailing
trends
flavonoid
investigation
studies,
elucidate
activity
flavonoids,
their
functions
uses,
assess
potential
flavonoids
preventive
medications
for
chronic
diseases,
outline
future
research
opportunities
this
field.
review
explores
preventing
managing
diseases.
Язык: Английский
Medicinal Plants as A Potential Resource for The Discovery of Novel Structures Towards Cancer Drug Resistance Treatment
Heliyon,
Год журнала:
2024,
Номер
10(20), С. e39229 - e39229
Опубликована: Окт. 1, 2024
Despite
extensive
research
in
chemotherapy,
global
cancer
concerns
persist,
exacerbated
by
the
challenge
of
drug
resistance,
which
imposes
economic
and
medical
burdens.
Natural
compounds,
particularly
secondary
metabolites
from
medicinal
plants,
present
promising
avenues
for
overcoming
resistance
due
to
their
diverse
structures
essential
pharmacological
effects.
This
review
provides
a
comprehensive
exploration
cell
mechanisms
target
actions
reversing
highlights
Язык: Английский