RNA Modification in Metabolism
MedComm,
Год журнала:
2025,
Номер
6(3)
Опубликована: Март 1, 2025
ABSTRACT
Epigenetic
regulation
in
disease
development
has
been
witnessed
within
this
decade.
RNA
methylation
is
the
predominant
form
of
epigenetic
regulation,
and
most
prevalent
modification
N6‐methyladenosine
(m
6
A).
Recently,
emerged
as
a
potential
target
for
treatment.
posttranscriptional
gene
expression
that
involved
both
physiological
pathological
processes.
Evidence
suggests
m
A
significantly
affects
metabolism,
its
abnormal
changes
have
observed
variety
diseases.
Metabolic
diseases
are
series
caused
by
metabolic
processes
body,
common
include
diabetes
mellitus,
obesity,
nonalcoholic
fatty
liver
disease,
etc.;
although
pathogenesis
these
differs
from
each
other
to
current
understanding,
recent
studies
suggested
pivotal
role
modulating
diseases,
A‐based
drug
on
agenda.
This
paper
reviewed
understanding
hoping
provide
systematic
information
those
area.
Язык: Английский
Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Апрель 18, 2025
Abstract
Angiogenesis,
a
crucial
process
in
tumor
growth
and
metastasis,
necessitates
targeted
therapeutic
intervention.
This
review
reviews
the
latest
knowledge
of
anti-angiogenesis
targets
tumors,
with
emphasis
on
molecular
mechanisms
signaling
pathways
that
regulate
this
process.
We
emphasize
microenvironment's
role
angiogenesis,
examine
endothelial
cell
metabolic
changes,
evaluated
potential
strategies
targeting
vascular
system.
At
same
time,
we
analyzed
pathway
mechanism
angiogenesis
detail.
In
addition,
paper
also
looks
at
development
trend
drugs,
including
their
future
direction
challenges,
aiming
to
provide
prospective
insight
into
field.
Despite
potential,
anti-angiogenic
therapies
encounter
challenges
like
drug
resistance
side
effects,
necessitating
ongoing
research
enhance
cancer
treatment
efficacy
these
therapies.
Язык: Английский