Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies DOI Creative Commons
Xiaohong Liu, Juan Zhang, Ting Yi

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 18, 2025

Abstract Angiogenesis, a crucial process in tumor growth and metastasis, necessitates targeted therapeutic intervention. This review reviews the latest knowledge of anti-angiogenesis targets tumors, with emphasis on molecular mechanisms signaling pathways that regulate this process. We emphasize microenvironment's role angiogenesis, examine endothelial cell metabolic changes, evaluated potential strategies targeting vascular system. At same time, we analyzed pathway mechanism angiogenesis detail. In addition, paper also looks at development trend drugs, including their future direction challenges, aiming to provide prospective insight into field. Despite potential, anti-angiogenic therapies encounter challenges like drug resistance side effects, necessitating ongoing research enhance cancer treatment efficacy these therapies.

Language: Английский

RNA Modification in Metabolism DOI Creative Commons
Yadi Liu,

Zhongyan Sun,

Dingkun Gui

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

ABSTRACT Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and most prevalent modification N6‐methyladenosine (m 6 A). Recently, emerged as a potential target for treatment. posttranscriptional gene expression that involved both physiological pathological processes. Evidence suggests m A significantly affects metabolism, its abnormal changes have observed variety diseases. Metabolic diseases are series caused by metabolic processes body, common include diabetes mellitus, obesity, nonalcoholic fatty liver disease, etc.; although pathogenesis these differs from each other to current understanding, recent studies suggested pivotal role modulating diseases, A‐based drug on agenda. This paper reviewed understanding hoping provide systematic information those area.

Language: Английский

Citations

0
Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies DOI Creative Commons
Xiaohong Liu, Juan Zhang, Ting Yi

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 18, 2025

Abstract Angiogenesis, a crucial process in tumor growth and metastasis, necessitates targeted therapeutic intervention. This review reviews the latest knowledge of anti-angiogenesis targets tumors, with emphasis on molecular mechanisms signaling pathways that regulate this process. We emphasize microenvironment's role angiogenesis, examine endothelial cell metabolic changes, evaluated potential strategies targeting vascular system. At same time, we analyzed pathway mechanism angiogenesis detail. In addition, paper also looks at development trend drugs, including their future direction challenges, aiming to provide prospective insight into field. Despite potential, anti-angiogenic therapies encounter challenges like drug resistance side effects, necessitating ongoing research enhance cancer treatment efficacy these therapies.

Language: Английский

Citations

0