Chimeric Antigen Receptor Cell Therapy: Empowering Treatment Strategies for Solid Tumors

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 90 - 90

Опубликована: Янв. 31, 2025

Chimeric antigen receptor-T (CAR-T) cell therapy has demonstrated impressive efficacy in the treatment of blood cancers; however, its effectiveness against solid tumors been significantly limited. The differences arise from a range difficulties linked to tumors, including an unfriendly tumor microenvironment, variability within and barriers CAR-T infiltration longevity at location. Research shows that reasons for decreased cells treating are not well understood, highlighting ongoing need strategies address these challenges. Current frequently incorporate combinatorial therapies designed boost functionality enhance their capacity effectively target tumors. However, remain testing phase necessitate additional validation assess potential benefits. CAR-NK (natural killer), CAR-iNKT (invariant natural killer T), CAR-M (macrophage) emerging as promising Recent studies highlight construction optimization cells, emphasizing overcome unique challenges posed by such hypoxia metabolic barriers. This review focuses on CAR

Язык: Английский

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CRISPR/Cas-mediated macromolecular DNA methylation editing: Precision targeting of DNA methyltransferases in cancer therapy

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142401 - 142401

Опубликована: Март 1, 2025

Язык: Английский

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From Gene Editing to Tumor Eradication: The CRISPR Revolution in Cancer Therapy

Progress in Biophysics and Molecular Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Advancing chronic myeloid leukemia research with next-generation sequencing: potential benefits, limitations, and future clinical integration

Human Genetics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Язык: Английский

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