Advancing chronic myeloid leukemia research with next-generation sequencing: potential benefits, limitations, and future clinical integration DOI
Henry Sutanto,

Laras Pratiwi,

Pradana Zaky Romadhon

et al.

Human Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

Chimeric Antigen Receptor Cell Therapy: Empowering Treatment Strategies for Solid Tumors DOI Creative Commons
Tang‐Her Jaing, Yi-Wen Hsiao, Yi-Lun Wang

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 90 - 90

Published: Jan. 31, 2025

Chimeric antigen receptor-T (CAR-T) cell therapy has demonstrated impressive efficacy in the treatment of blood cancers; however, its effectiveness against solid tumors been significantly limited. The differences arise from a range difficulties linked to tumors, including an unfriendly tumor microenvironment, variability within and barriers CAR-T infiltration longevity at location. Research shows that reasons for decreased cells treating are not well understood, highlighting ongoing need strategies address these challenges. Current frequently incorporate combinatorial therapies designed boost functionality enhance their capacity effectively target tumors. However, remain testing phase necessitate additional validation assess potential benefits. CAR-NK (natural killer), CAR-iNKT (invariant natural killer T), CAR-M (macrophage) emerging as promising Recent studies highlight construction optimization cells, emphasizing overcome unique challenges posed by such hypoxia metabolic barriers. This review focuses on CAR

Language: Английский

Citations

0
CRISPR/Cas-mediated macromolecular DNA methylation editing: Precision targeting of DNA methyltransferases in cancer therapy DOI

Feng Chena,

Lu Chenb

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142401 - 142401

Published: March 1, 2025

Language: Английский

Citations

0
From Gene Editing to Tumor Eradication: The CRISPR Revolution in Cancer Therapy DOI
Ashiq Ali,

Urooj Azmat,

Aisha Khatoon

et al.

Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Advancing chronic myeloid leukemia research with next-generation sequencing: potential benefits, limitations, and future clinical integration DOI
Henry Sutanto,

Laras Pratiwi,

Pradana Zaky Romadhon

et al.

Human Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

Citations

0