Journal of Pharmaceutical Research,
Год журнала:
2023,
Номер
8(2)
Опубликована: Июль 18, 2023
Regulatory
science
is
a
vital
component
of
pharmaceutical
development
and
approval
processes,
ensuring
the
safety,
efficacy,
quality
drugs.
This
article
provides
an
overview
background
importance
regulatory
in
industry.
It
highlights
critical
role
plays
supporting
innovation
creating
predictable
transparent
environment.
Recent
advances
are
discussed,
including
use
real-world
evidence,
innovative
trial
designs,
advancements
gene
cell
therapies.
These
developments
have
potential
to
revolutionize
drug
approval,
offering
new
treatment
options
improving
patient
outcomes.
However,
they
also
introduce
challenges
that
need
be
addressed,
such
as
reliability
evidence
adapting
complex
landscape
Understanding
evolving
field
crucial
for
professionals
navigate
bring
safe
effective
therapies
patients.
Molecules,
Год журнала:
2023,
Номер
28(10), С. 4014 - 4014
Опубликована: Май 10, 2023
A
potential
therapeutic
strategy
to
treat
conditions
brought
on
by
the
aberrant
production
of
a
disease-causing
protein
is
emerging
for
targeted
breakdown
using
PROTACs
technology.
Few
medications
now
in
use
are
tiny,
component-based
and
utilize
occupancy-driven
pharmacology
(MOA),
which
inhibits
function
short
period
time
temporarily
alter
it.
By
utilizing
an
event-driven
MOA,
proteolysis-targeting
chimeras
(PROTACs)
technology
introduces
revolutionary
tactic.
Small-molecule-based
heterobifunctional
hijack
ubiquitin–proteasome
system
trigger
degradation
target
protein.
The
main
challenge
PROTAC’s
development
facing
find
potent,
tissue-
cell-specific
PROTAC
compounds
with
favorable
drug-likeness
standard
safety
measures.
ways
increase
efficacy
selectivity
focus
this
review.
In
review,
we
have
highlighted
most
important
discoveries
related
proteins
PROTACs,
new
approaches
boost
proteolysis’
effectiveness
development,
promising
future
directions
medicine.
Applied Sciences,
Год журнала:
2023,
Номер
13(11), С. 6854 - 6854
Опубликована: Июнь 5, 2023
Digital
transformation,
characterised
by
advanced
digitalisation,
blockchain,
the
Internet
of
Things,
artificial
intelligence,
machine
learning
technologies,
and
robotics,
has
played
a
key
role
in
revolutionising
various
industries,
especially
healthcare
sector.
The
adoption
transition
(from
traditional)
to
new
technology
will
bring
challenges,
opportunities,
disruptions
existing
systems.
According
European
Union,
we
must
pursue
both
digital
green
transitions
achieve
sustainable,
human-centric,
resilient
industries
world
prosperity
for
all.
study
aims
present
novel
approach
education
training
health
field
that
is
inspired
fifth
industrial
revolution
paradigm.
paper
highlights
interventions
are
required
support
future
so
students
can
develop
capacity
recognise
exploit
potential
technologies.
This
article
briefly
discuss
challenges
opportunities
related
systems
era
transformation
beyond.
Then,
look
at
enabling
technologies
from
an
Industry
5.0
perspective
supports
health.
Finally,
teaching
paradigm
strategies
embed
academic
curricula
their
capacities
embrace
minimise
disruption
inevitably
accompany
it.
By
incorporating
principles
into
education,
believe
gain
deeper
understanding
industry
skills
enable
them
deliver
more
efficient,
effective,
sustainable
system.
Current Gene Therapy,
Год журнала:
2024,
Номер
24(3), С. 193 - 207
Опубликована: Фев. 4, 2024
With
the
discovery
of
CRISPR-Cas9,
drug
development
and
precision
medicine
have
undergone
a
major
change.
This
review
article
looks
at
new
ways
that
CRISPR-based
therapies
are
being
used
how
they
changing
way
is
done.
CRISPR
technology's
ability
to
precisely
flexibly
edit
genes
has
opened
up
find,
validate,
develop
targets.
Also,
it
made
for
personalized
gene
therapies,
precise
editing,
advanced
screening
techniques,
all
which
hold
great
promise
treating
wide
range
diseases.
In
this
article,
we
look
latest
research
clinical
trials
show
could
be
treat
genetic
diseases,
cancer,
infectious
other
hard-to-treat
conditions.
However,
ethical
issues
problems
with
regulations
also
discussed
in
relation
shows
important
use
them
safely
responsibly.
As
continues
change
drugs
used,
shines
light
on
amazing
things
been
done
what
future
might
rapidly
field.
Biomedical engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 23, 2024
In
an
era
where
technology
and
healthcare
increasingly
intertwine,
we
stand
on
the
precipice
of
a
seismic
shift
in
future
medicine.
This
chapter
unravels
confluence
mHealth,
artificial
intelligence
(AI),
radiology
as
it
navigates
labyrinth
these
advancements,
dissecting
their
unique
qualities,
historical
evolution,
projected
trajectories.
From
democratising
potential
mHealth
to
AI’s
analytical
might,
transformative
journey
medical
imaging
from
film
digital—the
offers
deep
dive
into
current
realities
horizons.
Further,
intersection
domains
is
explored,
illuminating
revolutionary
role
enhancing
capabilities
through
advances
imaging.
An
exhaustive
review
cutting-edge
applications
ethico-regulatory
conundrums
they
pose,
forms
substantial
part
discourse,
followed
by
foresight
anticipated
technological
breakthroughs,
impacts,
critical
policymakers
health
leaders
this
odyssey.
The
culminates
holistic
synthesis,
tying
together
strands
preceding
sections
underscore
triumvirate.
text
designed
captivating
exploration,
reflective
critique,
roadmap
for
collectively
navigate
towards
technologically
empowered
era.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 290 - 290
Опубликована: Фев. 22, 2025
Background:
The
integration
of
artificial
intelligence
(AI)
with
the
internet
things
(IoTs)
represents
a
significant
advancement
in
pharmaceutical
manufacturing
and
effectively
bridges
gap
between
digital
physical
worlds.
With
AI
algorithms
integrated
into
IoTs
sensors,
there
is
an
improvement
production
process
quality
control
for
better
overall
efficiency.
This
facilitates
enabling
machine
learning
deep
real-time
analysis,
predictive
maintenance,
automation—continuously
monitoring
key
parameters.
Objective:
paper
reviews
current
applications
potential
impacts
integrating
concert
technologies
like
cloud
computing
data
analytics,
within
sector.
Results:
Applications
discussed
herein
focus
on
industrial
analytics
quality,
underpinned
by
case
studies
showing
improvements
product
reductions
downtime.
Yet,
many
challenges
remain,
including
ethical
implications
AI-driven
decisions,
most
all,
regulatory
compliance.
review
also
discusses
recent
trends,
such
as
drug
discovery
blockchain
traceability,
intent
to
outline
future
autonomous
manufacturing.
Conclusions:
In
end,
this
points
basic
frameworks
that
illustrate
ways
overcome
existing
barriers
increased
efficiency,
personalization,
sustainability.
The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products Regulatory Research and Medicine Evaluation,
Год журнала:
2024,
Номер
14(1), С. 14 - 28
Опубликована: Фев. 27, 2024
SCIENTIFIC
RELEVANCE
.
The
rapid
expansion
of
the
range
medicines
in
global
pharmaceutical
market
determines
importance
periodically
reviewing
innovative
and
products
at
various
stages
development.
AIM.
This
study
aimed
to
determine
main
trends
development
medicines.
DISCUSSION
review
presents
information
on
therapeutic
effects
value
medicinal
products,
outlines
current
approaches
their
authorisation,
addresses
increase
costs.
authors
used
search,
content
analysis,
horizon
scanning
methods
prepare
this
narrative
review.
describes
pipeline
for
second
half
2023,
both
generally
by
specific
aspects.
determined
that
over
21,000
were
time,
with
approximately
23%
those
later
(from
phase
III
clinical
trials
registration
stage).
predominant
indications
use
cancers.
separately
reviewed
innovations
treatment
Alzheimer’s
disease,
as
well
gene,
cell,
RNA
therapies.
CONCLUSIONS.
A
significant
number
have
a
high
likelihood
changing
landscape
disease
treatment,
prevention,
diagnosis.
With
rising
costs
potential
change
underscores
introducing
predictive
tools,
such
scanning,
into
national
healthcare
system.
Frontiers in Medicine,
Год журнала:
2024,
Номер
10
Опубликована: Янв. 11, 2024
Strategic
regulatory
development
is
essential
to
ensure
that
new
innovations
in
nanotechnology-enabled
health
products
(NHPs)
successfully
reach
the
market
and
benefit
patients.
Currently,
lack
of
specific
guidelines
for
NHPs
considered
one
primary
causes
so-called
"valley
death"
these
products,
impacting
both
current
future
advancements.
In
this
study,
we
have
implemented
a
methodology
anticipate
key
trends
NHP
compare
them
with
landscape
applicable
NHPs.
This
relies
on
Horizon
Scanning,
tool
commonly
used
by
policymakers
foresee
needs
proactively
shape
framework
tailored
those
needs.
Through
application
methodology,
different
been
identified,
notably
drug
delivery
dental
applications.
Furthermore,
most
disruptive
elements
involve
are
multicomposite
multifunctional,
harnessing
nano-scale
properties
combine
therapeutic
diagnostic
purposes
within
single
product.
When
compared
landscape,
regulations
gradually
adapting
accommodate
emerging
trends,
being
developed.
However,
elements,
multifunctional
NHPs,
their
novelty
still
poses
significant
challenges,
requiring
strategic
agencies
safe
effective
integration
into
healthcare
practices.
study
underscores
importance
proactive
planning
bridge
gap
between
innovation
implementation.
