World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(3)
Опубликована: Фев. 26, 2025
Cognitive
impairment
is
one
of
the
common
clinical
manifestations
depression,
causing
negative
distress
to
patients.
Elevated
homocysteine
(Hcy)
concentrations
and
gut
microbiome
dysfunction
may
be
observed
in
patients
with
depression.
To
investigate
relationship
between
Hcy,
microbiome,
cognition
depressive
We
recruited
67
major
disorder
(MDD)
(MDD
group)
94
healthy
controls
(HCs)
individuals
(HCs
group).
Serum
Hcy
levels
were
determined
using
enzyme
circulation
method.
16s
rRNA
sequencing
was
used
classify
identify
fecal
bacteria.
17
Hamilton
depression
rating
scale
MATRICS
consensus
cognitive
battery
evaluate
mood
states
MDD.
Correlation
analysis
performed
explore
correlation
flora,
function.
serum
seen
MDD
compared
individuals.
Patients
indicated
significant
decreases
scores
(P
<
0.001)
six
modules:
Speed
processing,
working
memory,
visual
learning,
reasoning
problem-solving,
social
cognition,
total
scores.
showed
a
processing
speed,
0.05).
also
significantly
negatively
correlated
Alistipes,
Ruminococcae,
Tenericides,
Porphyromonas
Our
results
highlight
that
This
interaction
related
physiological
pathological
mechanisms
underlying
deficits
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(19), С. 11245 - 11245
Опубликована: Сен. 24, 2022
Modulating
the
gut
microbiome
and
its
influence
on
human
health
is
subject
of
intense
research.
The
microbiota
could
be
associated
not
only
with
gastroenterological
diseases
but
also
psychiatric
disorders.
importance
factors
such
as
stress,
mode
delivery,
role
probiotics,
circadian
clock
system,
diet,
occupational
environmental
exposure
in
relationship
between
brain
function
through
bidirectional
communication,
described
"the
microbiome-gut-brain
axis",
especially
underlined.
In
this
review,
we
discuss
link
intestinal
host
response
involving
different
pathways
nervous
system
(e.g.,
neurotransmitters,
endocrine
immunological
mechanisms,
or
bacterial
metabolites).
We
review
alterations
their
results
development
disorders,
including
major
depressive
disorder
(MDD),
schizophrenia
(SCZ),
bipolar
(BD),
autism
spectrum
(ASD),
attention-deficit
hyperactivity
(ADHD).
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2536 - 2536
Опубликована: Март 10, 2023
Polyphenols
are
an
important
component
of
plant-derived
food
with
a
wide
spectrum
beneficial
effects
on
human
health.
For
many
years,
they
have
aroused
great
interest,
especially
due
to
their
antioxidant
properties,
which
used
in
the
prevention
and
treatment
diseases.
Unfortunately,
as
any
chemical
substance,
depending
conditions,
dose,
interactions
environment,
it
is
possible
for
polyphenols
also
exert
harmful
effects.
This
review
presents
comprehensive
current
state
knowledge
negative
impact
health,
describing
side
polyphenol
intake,
form
supplements.
The
begins
brief
overview
physiological
role
potential
use
disease
prevention,
followed
by
exerted
particular
situations.
individual
chapters
discuss
consequences
polyphenols’
ability
block
iron
uptake,
some
subpopulations
can
be
harmful,
well
inhibition
digestive
enzymes,
intestinal
microbiota,
polyphenolic
compounds
drugs,
hormonal
balance.
Finally,
prooxidative
activity
mutagenic,
carcinogenic,
genotoxic
presented.
According
authors,
there
need
raise
public
awareness
about
supplementation,
case
vulnerable
subpopulations.
Medicine,
Год журнала:
2024,
Номер
103(5), С. e37114 - e37114
Опубликована: Фев. 2, 2024
The
gastrointestinal
tract
is
embedded
with
microorganisms
of
numerous
genera,
referred
to
as
gut
microbiota.
Gut
microbiota
has
multiple
effects
on
many
body
organs,
including
the
brain.
There
a
bidirectional
connection
between
and
brain
called
gut-brain-axis,
these
connections
are
formed
through
immunological,
neuronal,
neuroendocrine
pathways.
In
addition,
modulates
synthesis
functioning
neurotransmitters.
Therefore,
disruption
in
composition
or
function,
which
known
dysbiosis,
associated
pathogenesis
mental
disorders,
such
schizophrenia,
depression,
other
psychiatric
disorders.
This
review
aims
summarize
modulation
role
4
prominent
neurotransmitters
(tryptophan
serotonergic
system,
dopamine,
gamma-aminobutyric
acid,
glutamate),
well
its
association
disorders
(schizophrenia,
anxiety
autism
spectrum
disorder).
More
future
research
required
develop
efficient
gut-microbiota-based
therapies
for
illnesses.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
Microorganisms,
Год журнала:
2022,
Номер
10(6), С. 1151 - 1151
Опубликована: Июнь 2, 2022
Traditional
fermented
foods
and
beverages
play
an
important
role
in
a
range
of
human
diets,
several
experimental
studies
have
shown
their
potential
positive
effects
on
health.
Studies
from
different
continents
revealed
strong
associations
between
the
microorganisms
present
certain
(e.g.,
agave
fructans,
kefir,
yeats,
kombucha,
chungkookjang,
cheeses
vegetables,
among
others)
weight
maintenance,
reductions
risk
cardiovascular
disease,
antidiabetic
constipation
benefits,
improvement
glucose
lipids
levels,
stimulation
immunological
system,
anticarcinogenic
and,
most
importantly,
reduced
mortality.
Accordingly,
aim
this
review
is
to
corroborate
information
reported
that
comprised
interventions
involving
consumption
traditional
or
association
with
This
work
focuses
used
food
2014
present.
In
conclusion,
could
be
promotion
Further
are
needed
understand
mechanisms
involved
inflammatory,
immune,
chronic
gastrointestinal
diseases
roles
terms
preventing
managing
those
diseases.
Molecules,
Год журнала:
2022,
Номер
27(22), С. 7977 - 7977
Опубликована: Ноя. 17, 2022
Polyphenols
of
plant
origin
are
a
broad
family
secondary
metabolites
that
range
from
basic
phenolic
acids
to
more
complex
compounds
such
as
stilbenes,
flavonoids,
and
tannins,
all
which
have
several
phenol
units
in
their
structure.
Considerable
health
benefits,
having
prebiotic
potential
cardio-protective
weight
control
effects,
been
linked
diets
based
on
polyphenol-enriched
foods
plant-based
products,
indicating
the
role
these
substances
prevention
or
treatment
numerous
pathologies.
The
most
representative
apple
pomace
phloridzin,
chlorogenic
acid,
epicatechin,
with
major
implications
diabetes,
cancer,
cardiovascular
neurocognitive
diseases.
cereal
byproducts
rich
flavonoids
(cyanidin
3-glucoside)
(ferulic
acid),
significant
results
reducing
incidence
noncommunicable
Quercetin,
naringenin,
rutin
predominant
molecules
tomato
by-products,
important
antioxidant
antimicrobial
activities.
present
understanding
functionality
polyphenols
outcomes,
specifically,
illnesses,
is
summarized
this
review,
focusing
applicability
evidence
three
extensive
agrifood
industries
(apple,
cereal,
processing).
Moreover,
reintegration
by-products
into
food
chain
via
functional
products
personalized
nutrition
(e.g.,
3D
printing)
detailed,
supporting
novel
direction
be
explored
within
circular
economy
concept.
Nutrients,
Год журнала:
2022,
Номер
14(17), С. 3470 - 3470
Опубликована: Авг. 24, 2022
Cereal
processing
generates
around
12.9%
of
all
food
waste
globally.
Wheat
bran,
wheat
germ,
rice
corn
barley
and
brewery
spent
grain
are
just
a
few
examples
wastes
that
may
be
exploited
to
recover
bioactive
compounds.
As
result,
long-term
strategy
for
developing
novel
products
ingredients
is
encouraged.
High-value
compounds
like
proteins,
essential
amino
acids,
fatty
ferulic
acid,
other
phenols,
tocopherols,
or
β-glucans
found
in
cereal
by-products.
This
review
aims
provide
critical
comprehensive
overview
current
knowledge
regarding
the
recovered
from
by-products,
emphasizing
their
functional
values
potential
human
health
benefits.
Nowadays,
edible
materials
such
as
polysaccharides
have
gained
attention
due
to
their
valuable
attributes,
especially
gelling
property.
Polysaccharide-based
gels
(PEGs)
can
be
classified
(i)
hydrogels,
(ii)
oleogels
and
bigels,
(iii)
aerogels,
cryogels
xerogels,
respectively.
PEGs
different
characteristics
benefits
depending
on
the
functional
groups
of
polysaccharide
chains
(e.g.,
carboxylic,
sulphonic,
amino,
methoxyl)
preparation
method.
However,
are
found
in
incipient
phase
research
most
studies
related
preparation,
characterization,
sustainable
raw
materials,
applicability.
Furthermore,
all
these
aspects
treated
separately
for
each
class
PEG,
without
offering
an
overview
those
already
obtained
PEGs.
The
novelty
this
manuscript
is
offer
classification,
definition,
formulation,
characterization
applicability
food
sector
packaging,
improving
profile
agent,
delivery
systems)
medical/pharmaceutical
also
critically
discussed.
Ultimately,
correlation
between
PEG
consumption
properties
human
health
intestinal
microecology,
"
Molecules,
Год журнала:
2023,
Номер
28(4), С. 1533 - 1533
Опубликована: Фев. 5, 2023
The
Vaccinium
L.
(Ericaceae)
genus
consists
of
a
globally
widespread
and
diverse
around
4250
species,
which
the
most
valuable
is
Vaccinioidae
subfamily.
current
review
focuses
on
distribution,
history,
bioactive
compounds,
health-related
effects
three
species:
cranberry,
blueberry,
huckleberry.
Several
studies
highlight
that
consumption
spp.
presents
numerous
beneficial
outcomes,
including
antioxidant,
antimicrobial,
anti-inflammatory,
protective
against
diabetes,
obesity,
cancer,
neurodegenerative
diseases
cardiovascular
disorders.
These
plants’
prevalence
commercial
value
have
enhanced
in
past
several
years;
thus,
generated
by-products
also
increased.
Consequently,
identified
phenolic
compounds
found
discarded
leaves
these
plants
are
presented,
their
impact
health
economic
discussed.
main
this
belong
to
anthocyanins
(cyanidin,
malvidin,
delphinidin),
flavonoids
(quercetin,
isoquercetin,
astragalin),
acids
(gallic,
p-Coumaric,
cinnamic,
syringic,
ferulic,
caffeic
acids),
iridoids.
