The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117177 - 117177

Опубликована: Июль 24, 2024

Cytokines regulate immune responses essential for maintaining homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge promising therapeutic agents because they mitigate oxidative stress and modulate pathways. Antioxidants potentially ameliorate inflammation-related disorders by counteracting excessive cytokine-mediated responses. A comprehensive understanding of pathways the interplay with is paramount developing natural targeting helping improve clinical outcomes enhance quality life patients. Among these antioxidants, curcumin, vitamin C, D, propolis, allicin, cinnamaldehyde have garnered attention their anti-inflammatory properties potential benefits. This review highlights interrelationship between cytokines-mediated in various diseases approaches involving antioxidants.

Язык: Английский

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Gut Microbiota Dysbiosis, Oxidative Stress, Inflammation, and Epigenetic Alterations in Metabolic Diseases

Antioxidants, Год журнала: 2024, Номер 13(8), С. 985 - 985

Опубликована: Авг. 14, 2024

Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive production of reactive oxygen species (ROS), leading to inflammation, DNA damage, activation immune system, and epigenetic alterations critical genes involved metabolic pathways. dysbiosis-induced inflammation also disrupt barrier integrity increase intestinal permeability, which allows gut-derived toxic products enter liver systemic circulation, further triggering oxidative stress, associated with diseases. However, specific metabolites, such as short-chain fatty acids (SCFAs), lactate, vitamins, modulate stress system through mechanisms, thereby improving function. microbiota diet-induced diseases, obesity, insulin resistance, dyslipidemia, hypertension, transfer next generation, involving mechanisms. In this review, we will introduce key that, along dysbiosis ROS, are engaged developing Finally, discuss potential therapeutic interventions dietary modifications, prebiotics, probiotics, postbiotics, fecal transplantation, may reduce syndrome by altering alterations. summary, review highlights crucial role pathogenesis a particular focus on (including histone methylomics, RNA interference) that prevent or improve

Язык: Английский

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Impact of Metabolites from Foodborne Pathogens on Cancer

Foods, Год журнала: 2024, Номер 13(23), С. 3886 - 3886

Опубликована: Дек. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Язык: Английский

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The Role of the Gut Microbiota in Modulating Signaling Pathways and Oxidative Stress in Glioma Therapies

Cancers, Год журнала: 2025, Номер 17(5), С. 719 - 719

Опубликована: Фев. 20, 2025

Tumors of the central nervous system (CNS), especially gliomas, pose a significant clinical challenge due to their aggressive nature and limited therapeutic options. Emerging research highlights critical role gut microbiota in regulating CNS health disease. The composition is essential for maintaining homeostasis, as it modulates immune responses, oxidative status, neuroinflammation. microbiota–gut–brain axis, bidirectional communication network, plays pivotal cancer disease treatment, exerting its influence through neural, endocrine, immunological, metabolic pathways. Recent studies suggest that influences solidification tumor microenvironment dysbiosis may promote glioma development by modulating systemic inflammation stress, which contributes tumorigenesis progression. This review interrogates impact on glioma, focusing pathways such NF-κB, MAPK, PI3K/Akt/mTOR, Kynurenine/AhR drive proliferation, evasion, therapy resistance. Furthermore, we explore emerging strategies, including probiotics microbiota-based interventions, show potential these enhancing immunotherapies checkpoint inhibitors. By multifaceted interactions between microbiota, tumors, this microbiota-targeted therapies manipulation complement enhance current treatments.

Язык: Английский

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Gut Microbiota Serves as a Crucial Independent Biomarker in Inflammatory Bowel Disease (IBD)

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2503 - 2503

Опубликована: Март 11, 2025

Inflammatory bowel disease (IBD), encompassing Crohn’s (CD), ulcerative colitis (UC), and IBD unclassified (IBD-U), is a complex intestinal disorder influenced by genetic, environmental, microbial factors. Recent evidence highlights the gut microbiota as pivotal biomarker modulator in pathogenesis. Dysbiosis, characterized reduced diversity altered composition, hallmark of IBD. A consistent decrease anti-inflammatory bacteria, such Faecalibacterium prausnitzii, an increase pro-inflammatory species, including Escherichia coli, have been observed. Metabolomic studies reveal decreased short-chain fatty acids (SCFAs) secondary bile acids, critical for homeostasis, alongside elevated metabolites. The interacts with host immune pathways, influencing morphogens, glycosylation, podoplanin (PDPN) expression. disruption glycosylation impairs mucosal barriers, while aberrant PDPN activity exacerbates inflammation. Additionally, alterations contribute to oxidative stress, further destabilizing barriers. These molecular cellular disruptions underscore role microbiome pathophysiology. Emerging therapeutic strategies, probiotics, prebiotics, dietary interventions, aim restore balance mitigate Advanced on microbiota-targeted therapies their potential reduce severity improve patient outcomes. Nevertheless, research needed elucidate bidirectional interactions between responses translate these insights into clinical applications. This review consolidates current findings microbiota’s IBD, emphasizing its diagnostic implications, advocates continued exploration microbiome-based interventions combat this debilitating disease.

Язык: Английский

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Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Pathophysiology, Год журнала: 2024, Номер 31(3), С. 309 - 330

Опубликована: Июнь 21, 2024

Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating existence microbiome–oxidative interaction. However, biochemical basis this interaction still unclear. In narrative review, possible pathways microbiota and are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, melatonin also appear to roles. Moreover, relationship between microbiome obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, medications considered. An investigation correlation bacterial community features OS parameter changes under normal pathological conditions might provide information for determination new methods. Furthermore, such could contribute establishing a foundation determining linkers microbiome–OS association.

Язык: Английский

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Berberine: Potential preventive and therapeutic strategies for human colorectal cancer

Cell Biochemistry and Function, Год журнала: 2024, Номер 42(4)

Опубликована: Май 14, 2024

Colorectal cancer (CRC) is a common digestive tract tumor, with incidences continuing to rise. Although modern medicine has extended the survival time of CRC patients, its adverse effects and financial burden cannot be ignored. multi-step process can caused by disturbance gut microbiome chronic inflammation's stimulation. Additionally, presence precancerous lesions also risk factor for CRC. Consequently, scientists are increasingly interested in identifying multi-target, safe, economical herbal natural products. This paper summarizes berberine's (BBR) regulatory mechanisms occurrence development The findings indicate that BBR regulates homeostasis controls mucosal inflammation prevent In stage, inhibits cell proliferation, invasion, metastasis, blocks cycle, induces apoptosis, metabolism, angiogenesis, enhances chemosensitivity. plays role overall management Therefore, using as an adjunct prevention treatment could become future trend oncology.

Язык: Английский

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Population-specific differences in the human microbiome: Factors defining the diversity

Gene, Год журнала: 2024, Номер 933, С. 148923 - 148923

Опубликована: Сен. 6, 2024

Язык: Английский

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Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1062 - 1062

Опубликована: Авг. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Язык: Английский

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Unraveling the Impact of Micro- and Nano-sized Polymethyl methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126157 - 126157

Опубликована: Март 1, 2025

Язык: Английский

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