Antidepressant mechanisms of ketamine: a review of actions with relevance to treatment-resistance and neuroprogression

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Авг. 8, 2023

Concurrent with recent insights into the neuroprogressive nature of depression, ketamine shows promise in interfering several factors, and has been suggested to reverse neuropathological patterns seen depression. These come at a time great need for novel approaches, as prevalence is rising current treatment options remain inadequate large number people. The rapidly growing literature on ketamine's antidepressant potential yielded multiple proposed mechanisms action, many which have implications recently elucidated aspects depressive pathology. This review aims provide reader an understanding pathology how act it. Literature was identified through PubMed Google Scholar, reference lists retrieved articles. When reviewing evidence pathology, picture emerges four elements interacting each other facilitate progressive worsening, namely stress, inflammation, neurotoxicity neurodegeneration. Ketamine acts all these levels rapid potent reductions symptoms. Converging suggests that works increase stress resilience stress-induced dysfunction, modulate systemic inflammation neuroinflammation, attenuate neurotoxic processes glial synaptogenesis rather than Still, much remains be revealed about research lacking durability effect. findings discussed herein calls more longitudinal approaches when determining efficacy its relation could relevant considerations clinical implementation.

Язык: Английский

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Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease

Neural Regeneration Research, Год журнала: 2023, Номер 18(12), С. 2611 - 2614

Опубликована: Май 12, 2023

This critical review of the literature shows that there is a close link between microbiome, gut, and brain in Parkinson's disease. The vagus nerve, main component parasympathetic nervous system, involved regulation immune response, digestion, heart rate, control mood. It can detect microbiota metabolites through its afferents, transferring this gut information to central system. Preclinical clinical studies have shown important role played by microbiome gut-related factors disease development progression, as well treatment responses. These findings suggest may be valuable target for new therapeutic strategies More are needed better understand underlying biology how axis modulated patient's benefit.

Язык: Английский

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Bioactive Potential of Elderberry (Sambucus nigra L.): Antioxidant, Antimicrobial Activity, Bioaccessibility and Prebiotic Potential

Molecules, Год журнала: 2023, Номер 28(7), С. 3099 - 3099

Опубликована: Март 30, 2023

Due to its abundance of physiologically active ingredients, one the oldest medicinal herbs, elderberry (EB) Sambucus nigra L., is beneficial for both therapeutic and dietary purposes. This study determined bioaccessibility phenolic compounds prebiotic potential polyphenols from freeze-dried EB powder (FDEBP), along with antioxidant antimicrobial activities this extract. The most significant in black are represented by anthocyanins (41.8%), predominating cyanidin-sambubiosides cyanidin-glucosides (90.1% identified anthocyanins). FRAP assay obtained highest activity value (185 ± 0.18 μmol Fe2+/g DW). sensitive extract was proven be Staphylococcus aureus, Pseudomonas aeruginosa had lowest minimum inhibitory concentration 1.95 mg/mL. To determine polyphenols, cell growth five probiotic strains (Lactobacillus plantarum, L. casei, rhamnosus, fermentum Saccharomyces boulardii) tested. influence on positive all used. Overall, increase (p < 0.05) recorded at 1.5% FDEBP, casei a index (GI) 152.44%, very closely followed GI 0.5% 1% concentrations. stability total through simulated gastronitestinal digestion increased (93%), also elevated (75%).

Язык: Английский

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Gut microbiota: A magical multifunctional target regulated by medicine food homology species

Journal of Advanced Research, Год журнала: 2023, Номер 52, С. 151 - 170

Опубликована: Июнь 2, 2023

The relationship between gut microbiota and human health has gradually been recognized. Increasing studies show that the disorder of is related to occurrence development many diseases. Metabolites produced by are responsible for their extensive regulatory roles. In addition, naturally derived medicine food homology species with low toxicity high efficiency have clearly defined owing outstanding physiological pharmacological properties in disease prevention treatment.Based on supporting evidence, current review summarizes representative work targeting regulate host pathophysiology discusses challenges prospects this field. It aims facilitate understanding among species, microbiota, further stimulate advancement more relevant research.As reveals, from initial practical application mechanism studies, evolved into an irrefutable interaction. On one hand, through affecting population structure, metabolism, function maintain homeostasis intestinal microenvironment microbiota. other also involved bioconversion active ingredients thus influences properties.

Язык: Английский

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SMOTE-kTLNN: A hybrid re-sampling method based on SMOTE and a two-layer nearest neighbor classifier

Expert Systems with Applications, Год журнала: 2023, Номер 238, С. 121848 - 121848

Опубликована: Сен. 29, 2023

Язык: Английский

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Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders

Neuronal Signaling, Год журнала: 2023, Номер 7(4)

Опубликована: Окт. 27, 2023

Abstract Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well when and how these experienced or expressed. It is focal overarching symptom in many severe prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit/hyperactivity disorder (ADHD), borderline personality (BPD). In all disorders, ED can manifest through symptoms depression, anxiety, affective lability. Considering symptomatic similarities between BD, ADHD, BPD, transdiagnostic approach promising lens investigation. Mounting evidence supports role peripheral inflammatory markers stress multifactorial aetiology physiopathology BPD. Of note, neural circuits that regulate appear particularly vulnerable to insults inflammation, impact neuroimmune milieu central nervous system. Thus far, few studies have examined link inflammation To our knowledge, no specific work has provided critical comparison results from disorders. fill this gap literature, we review known associations mechanisms linking general, clinically, BD. Our narrative begins an examination routes followed by discussion disorder-specific accounting for methodological limitations relevant confounding factors. Finally, critically discuss both correspondences discrepancies comment on potential vulnerability therapeutic interventions.

Язык: Английский

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Role of gastrointestinal health in managing children with autism spectrum disorder

World Journal of Clinical Pediatrics, Год журнала: 2023, Номер 12(4), С. 171 - 196

Опубликована: Сен. 5, 2023

Children with autism spectrum disorders (ASD) or are more prone to gastrointestinal (GI) than the general population. These can significantly affect their health, learning, and development due various factors such as genetics, environment, behavior. The causes of GI in children ASD include gut dysbiosis, immune dysfunction, food sensitivities, digestive enzyme deficiencies, sensory processing differences. Many studies suggest that numerous experience problems, effective management is crucial. Diagnosing typically done through genetic, neurological, functional, behavioral assessments observations, while tests not consistently reliable. Some may increase risk developing exacerbating symptoms. Addressing issues individuals improve overall well-being, leading better behavior, cognitive function, educational abilities. Proper digestion, nutrient absorption, appetite by relieving physical discomfort pain. Alleviating symptoms sleep patterns, energy levels, contribute a sense ultimately quality life for individual improved family dynamics. primary goal interventions nutritional status, reduce symptom severity, promote balanced mood, patient independence.

Язык: Английский

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Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102476 - 102476

Опубликована: Авг. 31, 2024

Язык: Английский

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Gut-brain axis interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer’s disease

Virulence, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 10, 2024

Helicobacter pylori is a pathogenic bacterium that causes gastritis and gastric carcinoma. Besides complications its potential link with gut-brain axis disruption neurological disorders has also been reported. The current study investigated the plausible role associated molecular mechanism underlaying H. mediated neuroinflammation leading to modalities like Alzheimer's disease (AD). We have chosen antimicrobial resistant susceptible strains on basis of broth dilution method. observed increased inflammatory response exerted by in as well neuronal compartment after treatment derived condition media (HPCM). Further, elevated expression STAT1, STAT3, AD-associated proteins- APP APOE4 was monitored HPCM-treated neuron-astrocyte co-cultured cells. Excessive ROS generation found these HPCM LN229 astrogliosis, evidenced glial fibrillary acidic protein. Our results indicate association STAT3 an important regulator pylori-mediated pathogenesis Notably, inhibition specific inhibitor, BP-1-102, reduced pSTAT3 AD markers induced HPCM. Thus, our demonstrates infection exacerbates inflammation AGS cells modulates activity regulatory molecules. secretome could affect compartments promoting activation inducing signature markers. pSTAT-3 mitigates amyloid pathology.

Язык: Английский

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Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2024, Номер 134, С. 111073 - 111073

Опубликована: Июнь 22, 2024

One of the most challenging and controversial issues in microbiome research is related to gut microbial metabolism neuropsychological disorders. Psychobiotics affect human behavior central nervous system processes via gut-brain axis, involving neuronal, immune, metabolic pathways. They have therapeutic potential treatment several neurodegenerative neurodevelopmental disorders such as depression, anxiety, autism, attention deficit hyperactivity disorder, Alzheimer's disease, Parkinson's schizophrenia, Huntington's anorexia nervosa, multiple sclerosis. However, mechanisms underlying interaction between psychobiotics abovementioned diseases need further exploration. This review focuses on relationship microbiota its impact neurological disorders, examining a preventive approach, summarising recent axis beneficial effects psychobiotics, highlighting for investigation this area.

Язык: Английский

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