The Influence of the Gut Microbiota on Host Health: A Focus on the Gut–Lung Axis and Therapeutic Approaches
Life,
Год журнала:
2024,
Номер
14(10), С. 1279 - 1279
Опубликована: Окт. 9, 2024
The
human
gut
microbiota
is
a
complex
ecosystem
harboring
thousands
of
microbial
strains
that
play
crucial
role
in
maintaining
the
overall
well-being
its
host.
composition
varies
with
age
from
infancy
to
adulthood
and
influenced
by
dietary
habits,
environment,
genetic
disposition.
Recent
advances
culture-independent
techniques
nucleic
acid
sequencing
have
improved
our
understanding
diversity
microbiota.
species
present
release
short-chain
fatty
acids
(SCFAs),
which
anti-inflammatory
properties.
also
plays
substantial
modulating
host's
immune
system,
promoting
tolerance,
homeostasis.
impact
on
health
host
quite
evident,
as
dysbiosis
has
been
linked
various
diseases,
including
metabolic
disorders,
autoimmune
allergies,
inflammatory
bowel
diseases.
bidirectional
communication
respiratory
creating
gut-lung
axis,
associated
different
Therapeutic
approaches
targeting
microbiota,
such
probiotics,
prebiotics,
interventions,
fecal
transplantation
(FMT),
aim
restore
balance
promote
growth
beneficial
gut.
Nonetheless,
gaining
knowledge
interactions
between
necessary
develop
personalized
medicine
microbiota-based
therapies
for
conditions.
This
review
summarizes
studies
related
axis
particular
emphasis
Future
research
directions
are
discussed.
Язык: Английский
The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease
Xiaofan Song,
Xina Dou,
Jiajing Chang
и другие.
Gut Microbes,
Год журнала:
2024,
Номер
16(1)
Опубликована: Окт. 24, 2024
The
current
studies
have
shown
that
the
occurrence
and
development
of
chronic
obstructive
pulmonary
disease
(COPD)
are
closely
related
to
changes
in
gut
health
its
microenvironment,
even
some
diseases
significant
clinical
correlation
with
COPD.
dysbiosis
microbiota
observed
COPD
patients
also
suggests
a
potential
bidirectional
interaction
between
lung.
Communication
lung
may
occur
through
circulating
inflammatory
cells,
microbial
metabolites,
mediators,
but
mechanism
communication
is
still
under
study.
Therefore,
more
research
needed
this
area.
In
review,
we
summarize
recent
animal
models
on
role
gut-lung
axis
mechanisms,
so
as
provide
ideas
for
further
field.
addition,
summarized
negative
effects
medication
risk
factors
proposed
prevention
treatment
strategies.
Язык: Английский
Gut Microbiota Modulation in the Management of Chronic Obstructive Pulmonary Disease: A Literature Review
Srihita Patibandla,
Nilay Bhatt,
Sean Lief
и другие.
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 14, 2024
Chronic
obstructive
pulmonary
disease
(COPD)
represents
a
significant
global
health
burden,
characterized
by
progressive
airflow
limitation
and
exacerbations
that
significantly
impact
patient
morbidity
mortality.
Recent
research
has
investigated
the
interplay
between
gut
lungs,
known
as
gut-lung
axis,
highlighting
role
of
microbiome
in
COPD
pathogenesis.
Dysbiosis,
microbial
imbalance,
implications
for
COPD,
influencing
progression
susceptibility
to
exacerbations.
This
comprehensive
review
integrates
current
scientific
literature
on
microbiota
modulation
therapeutic
avenue
management.
Through
thorough
discussion
studies
investigating
probiotics,
prebiotics,
synbiotics,
antibiotics,
dietary
fiber,
fecal
transplantation,
this
summarizes
influence
these
interventions
via
axis
through
systemic
inflammation,
mucosal
immunity,
metabolic
processes.
The
highlighted
here
show
potential
preventing
exacerbations,
preserving
lung
function,
improving
quality
life.
By
compiling
latest
evidence,
provides
framework
physicians
researchers
deduce
effectiveness
an
adjunctive
strategy
Язык: Английский