Опубликована: Янв. 1, 2024
Язык: Английский
Biomedical Chromatography, Год журнала: 2025, Номер 39(3)
Опубликована: Фев. 7, 2025
Artemisia campestris subsp. (tuguft) is a medicinal plant traditionally used in Algerian medicine. This study investigates the chemical composition and bioactivity of its essential oil (ACEO). Gas chromatography-mass spectrometry (GC-MS) analysis identified key compounds, including linalyl acetate (2.92%), geranyl (2.45%), eucalyptol (1.38%). ACEO demonstrated significant antioxidant activity, with IC50 values 11.09 μg/mL (DPPH), 15.81 (FRAP), 22.70 (β-carotene). It also enhanced peroxidase activity by 82.67 U/g. The anti-inflammatory effects were confirmed an 18.87 μg/mL. Notably, silico molecular docking revealed that 3-cyclopentyl-N-(2-(3,4-dimethoxyphenyl)ethyl) exhibits strong binding affinity to phosphoinositide 3-kinase gamma, target for pancreatic cancer therapy, suggesting potential anticancer activity. These findings underscore therapeutic ACEO, highlighting antioxidant, anti-inflammatory, properties.
Язык: Английский
Процитировано
1
Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 137345 - 137345
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
AMB Express, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 27, 2025
Abstract The increasing demand for natural alternatives to synthetic fungicides has prompted research into products like essential oils postharvest disease management. This study investigated the antifungal, antioxidant, cytotoxic, and genotoxic potential of oil mixtures derived from oregano, rosemary, mint against Penicillium digitatum , predominant fungal pathogen causing green mold in orange fruits. P. NPAGRASU 2024 was isolated identified as most abundant species (60.2%) infected oranges. It deposited GenBank with gene accession number PP930644 MIRCEN culture collection EMCC 358874. antimicrobial activity individual evaluated, oregano exhibiting highest antifungal (inhibition zone diameter 4.2 cm) . L-optimal mixture design response surface methodology (RSM) optimization revealed a highly effective (Run 8) comprising 46.26% 53.74% 99.65% actual growth reduction. demonstrated potent antioxidant activity, reaching approximately 75% DPPH radical scavenging at 3.125 mg/mL. Cytotoxicity assessment using MTT assay showed morphological changes reduced cell viability liver cells treated PEOs 300 µg/mL. However, optimized did not induce significant chromosomal aberrations compared control, suggesting minimal effects. In vivo, evaluation on oranges 60% inhibition by 1% (v/v) 7 days. Histological analysis indicated low toxicity tested concentration (1% mixture). GC-MS major compounds cavarcol, caryophyllene, eucalyptol, phenols levomenthol oil, contributing its bioactivities. demonstrates eco-friendly control.
Язык: Английский
Процитировано
0
Antibiotics, Год журнала: 2025, Номер 14(2), С. 146 - 146
Опубликована: Фев. 2, 2025
Background/Objectives: Bacterial resistance to antibiotics is a major problem in healthcare, complicated by the ability of bacteria form biofilms. Complementary therapy for infectious diseases can rely on natural substances with antibacterial activity, e.g., essential oils and honeys. The aim study was investigate effects linden chestnut honeys, lavender oil, their combinations against multidrug-resistant otitis media pathogens Haemophilus influenzae, H. parainfluenzae, Moraxella catarrhalis, Pseudomonas aeruginosa, Streptococcus pneumoniae. efficacy these compared each other used clinical practice. Methods: Microscopic pollen analysis physicochemical traits were confirm botanical origin honey samples. antibiotic sensitivity tested disk diffusion assay. Minimum inhibitory concentrations determined using microdilution A 24 h immature biofilm eradication test performed crystal violet checkerboard titration method. DNA release damaged bacterial cells measured membrane degradation Results: Lavender oil displayed more potent activity However, honey–essential showed higher inhibition rates eradication, P. aeruginosa being most resistant bacterium. combined use resulted degree shorter time, synergistic effect proven titration. Conclusions: combination or shown be effective formed M. S.
Язык: Английский
Процитировано
0
Fungal biology, Год журнала: 2025, Номер unknown, С. 141 - 172
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Food Science & Nutrition, Год журнала: 2025, Номер 13(4)
Опубликована: Март 24, 2025
ABSTRACT This study explores the extraction of Anethum graveolens essential oil (EO) using advanced techniques, including Superheated Steam Extraction (SHSE), and compares them with traditional methods such as Hydro Distillation (HD), (SD), Supercritical Carbon Dioxide (SCF‐CO 2 ). The novelty this research lies in comprehensive evaluation SHSE, a relatively underexplored method, for its effectiveness enhancing both yield biological activities EO. provides detailed comparative analysis antioxidant antimicrobial properties across different methods. SHSE method yielded highest activity, DPPH scavenging (87.48%) total capacity (measured by FRAP, 163.06 mg/L), outperforming EO's high content key components carvone, limonene, dillapiole significantly contributes to enhanced activities. These findings underscore superior efficacy extracting oils, offering new insights into their potential applications health wellness, which set apart from previous work.
Язык: Английский
Процитировано
0
Journal of Food Composition and Analysis, Год журнала: 2025, Номер unknown, С. 107535 - 107535
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 381 - 384
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 365 - 380
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 3 - 14
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0