Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes DOI Open Access

S. P. Singh,

Rakesh Bhaskar, Shampa Ghosh

и другие.

Cancers, Год журнала: 2025, Номер 17(7), С. 1082 - 1082

Опубликована: Март 24, 2025

Cancer is complex because of the critical imbalance in genetic regulation as characterized by both overexpression oncogenes (OGs), mainly through mutations, amplifications, and translocations, inactivation tumor-suppressor genes (TSGs), which entail preservation genomic integrity inducing apoptosis to counter malignant growth. Reviewing intricate molecular interplay between OGs TSGs draws attention their cell cycle, apoptosis, cancer metabolism regulation. In present review, we discuss seminal discoveries, such Knudson's two-hit hypothesis, framed field's understanding genetics, leading next breakthroughs with next-generation sequencing epigenetic profiling, revealing novel insights into OG TSG dysregulation opportunities for targeted therapy. The key pathways, MAPK/ERK, PI3K/AKT/mTOR, Wnt/β-catenin, are presented context tumor progression. Importantly, further highlighted advances therapeutic strategies, including inhibitors KRAS MYC restoration function, despite mechanisms resistance heterogeneity pose daunting challenges. A high-level interactions OG-TSGs forms basis effective, personalized treatment-something strive better clinical outcomes. This synthesis should integrate foundational biology translation and, this case, contribute ongoing effort against cancer.

Язык: Английский

Exosomes in Precision Oncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics DOI Open Access

Emile M. Youssef,

Dannelle Palmer,

Brandon Fletcher

и другие.

Cancers, Год журнала: 2025, Номер 17(6), С. 940 - 940

Опубликована: Март 10, 2025

Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.

Язык: Английский

Процитировано

0
Zooplankton biomass as a promising new agent for biomedical applications DOI
Hamdy A. Abo‐Taleb, Abdelrahman M. Khattab, Mansour A.E. Bashar

и другие.

Biocatalysis and Agricultural Biotechnology, Год журнала: 2025, Номер unknown, С. 103560 - 103560

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes DOI Open Access

S. P. Singh,

Rakesh Bhaskar, Shampa Ghosh

и другие.

Cancers, Год журнала: 2025, Номер 17(7), С. 1082 - 1082

Опубликована: Март 24, 2025

Cancer is complex because of the critical imbalance in genetic regulation as characterized by both overexpression oncogenes (OGs), mainly through mutations, amplifications, and translocations, inactivation tumor-suppressor genes (TSGs), which entail preservation genomic integrity inducing apoptosis to counter malignant growth. Reviewing intricate molecular interplay between OGs TSGs draws attention their cell cycle, apoptosis, cancer metabolism regulation. In present review, we discuss seminal discoveries, such Knudson's two-hit hypothesis, framed field's understanding genetics, leading next breakthroughs with next-generation sequencing epigenetic profiling, revealing novel insights into OG TSG dysregulation opportunities for targeted therapy. The key pathways, MAPK/ERK, PI3K/AKT/mTOR, Wnt/β-catenin, are presented context tumor progression. Importantly, further highlighted advances therapeutic strategies, including inhibitors KRAS MYC restoration function, despite mechanisms resistance heterogeneity pose daunting challenges. A high-level interactions OG-TSGs forms basis effective, personalized treatment-something strive better clinical outcomes. This synthesis should integrate foundational biology translation and, this case, contribute ongoing effort against cancer.

Язык: Английский

Процитировано

0