bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Апрель 18, 2023

Abstract Cyanobacteria have emerged as attractive microbial cell factories, they can convert atmospheric CO 2 and sunlight into valuable chemicals. To increase their growth productivity, one should aim to optimize the allocation of limited cellular resources across different metabolic processes. Here, we developed two balance analysis (GBA) models for cyanobacterium Synechocystis sp. PCC 6803. In its biological assumptions, closely related an existing coarse-grained model, while mathematical formulation is heavily streamlined. We show that GBA provide virtually identical predictions about resource among photosynthesis, carbon metabolism, protein translation machinery under environmental conditions previous, mathematically more involved model. Our model also captures effects photodamage on proteome resulting rates. further how be easily extended include reactions, leading a second capable new allocation. Balanced type presented here expanded details, providing useful toolbox understanding physiological capabilities cyanobacteria, resources, potential bioengineering optimized biomass production.

Язык: Английский