Journal of Oral and Maxillofacial Pathology,
Год журнала:
2024,
Номер
28(4), С. 665 - 671
Опубликована: Окт. 1, 2024
In
recent
years,
Candida
albicans
has
emerged
as
a
significant
opportunistic
pathogen,
causing
various
infections,
particularly
in
immunocompromised
geriatric
individuals.
One
of
the
major
hindrances
managing
infections
lies
its
potential
to
develop
and
survive
biofilms,
which
demonstrate
resistance
conventional
antifungal
therapies,
thereby
complicating
treatment
strategies.
While
clove
oil
shown
promising
results
agent,
specific
anti-biofilm
effects
against
biofilms
remain
relatively
underexplored.
Therefore,
there
is
need
for
comprehensive
review
evaluate
existing
literature
on
properties
mechanisms
action
biofilms.
Such
will
provide
valuable
insights
into
therapeutic
applications
combating
biofilm-associated
infections.
This
enable
us
infer
understand
albicans.
systematic
aims
determine
efficacy
was
registered
'PROSPERO'
(CRD42024524134)
followed
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
guidelines.
The
searches
used
Google
Scholar,
PubMed,
Science
Direct
databases.
All
original
studies
published
English
from
2004
2023
were
included.
From
37
found
online,
only
four
reviewed.
Results
showed
that
had
activity
when
assessed
Our
provides
oil's
agent
Clove
also
represents
avenue
future
research
development
This
study
was
conducted
to
investigate
the
efficiency
of
periodontal
ligament
(PDL)
stem
cell-derived
exosome-loaded
Emodin
(Emo@PDL-Exo)
in
antimicrobial
photodynamic
therapy
(aPDT)
on
Streptococcus
mutans
and
Lactobacillus
acidophilus
as
cariogenic
bacteria.
Acinetobacter
baumannii's
extensive
antibiotic
resistance
makes
its
infections
difficult
to
treat,
so
effective
strategies
fight
this
bacterium
are
urgently
needed.
This
study
aims
evaluate
the
effectiveness
of
antimicrobial
photodynamic
therapy
(aPDT)
mediated
by
Rutin-Gal(III)
complex
and
Quercetin
against
A.
baumannii.
Absorbance
spectra,
fluorescence
minimum
inhibitory
concentration
(MIC)
were
determined.
The
intracellular
reactive
oxygen
species
(ROS),
extracellular
polymeric
substances
(EPS),
cell
membrane
permeability,
expression
ompA
blaOXA−23,
anti-biofilm
activity,
anti-metabolic
activity
complex-
Quercetin-mediated
aPDT
measured.
revealed
absorption
peaks
in
visible
spectra.
displayed
at
524
nm
540
nm,
respectively.
MIC
values
for
64
µg/mL
256
µg/mL,
Quercetin-
complex-mediated
significantly
reduced
colony
forming
units/mL
(58.4%
67.5%),
EPS
synthesis
(47.4%
56.5%),
metabolic
(30.5%
36.3%),
(5.5-
10.5-fold),
blaOXA−23
(4.1-fold
7.8-fold)
genes
(respectively;
all
P
<
0.05).
enhanced
notable
biofilm
degradation
(36.2%
40.6%),
ROS
production
(2.55-
2.90-folds),
permeability
(10.8–
9.6-folds)
findings
indicate
that
exhibits
antibacterial
properties
could
serve
as
a
valuable
adjunctive
strategy
conventional
treatments
baumannii
infections.
One
limitation
is
it
was
conducted
solely
on
standard
strain;
testing
clinical
isolates
would
allow
more
reliable
interpretation
results.
Research Journal of Pharmacy and Technology,
Год журнала:
2024,
Номер
unknown, С. 4929 - 4933
Опубликована: Окт. 22, 2024
Background:
Periodontitis
is
an
inflammation
that
occurs
in
the
periodontium
and
caused
by
host
immune
responses
subgingival
plaque
bacteria.
Subgingival
bacteria
can
initiate
periodontal
disease
because
they
have
potential
to
induce
release
of
proinflammatory
cytokines.
Mechanical
debridement
alone
not
always
possible
completely
remove
pathogenic
cause
infections
due
accessibility
location.
New
treatments,
such
as
photodynamic
therapy,
which
uses
lasers,
offer
alternative
option.
Photodynamic
therapy
a
non-invasive
photons
light
energy
for
medical
purposes.
The
mechanism
based
on
triad
consisting
photosensitizer,
source,
molecular
oxygen.
Microorganisms
first
absorb
then
are
activated
specific
wavelength.
Photosensitizer
transfer
received
oxygen
convert
into
ROS,
death
microorganisms
affecting
their
membranes,
proteins,
nucleic
acids.
Doxycycline
widely
used
known
act
exogenous
photosensitizer.
Objective:
aim
research
was
evaluate
doxycycline
photosensitizer
against
Method:
diffusion
method
test
bacterial
inhibition
with
4
replications.
This
divided
6
groups:
(1)
control,
(2)
(3)
0,0125%
(4)
0,025%
(5)
0,05%
(6)
0,1%
therapy.
were
collected
from
stock
put
reaction
tube
contained
liquid
BHIB.
After
that,
culture
incubated
48hours
at
37ºC,
planted
Mueller
Hinton
agar
spreading
technique.
Filter
paper
inserted
each
concentrations
placed
petridish
has
been
wavelength
405nm
30
seconds
exposed
paper.
Then,
plates
48
hours
37ºC.
Result:
avarage
zone
obtained
following
0mm,
13.375mm,
14.6125mm,
15.450mm,
17.325mm,
19.2875mm.
Conclusion:
0.1%
concentration
group
combined
biggest
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
Antimicrobial
photodynamic
therapy
(aPDT)
has
been
suggested
as
a
complementary
approach
to
endodontic
treatment
it
promoted
greater
microbial
reduction.
This
case
report
describes
the
effectiveness
of
aPDT
in
bacterial
reduction
and
clinical
management
lower
molar
presenting
previous
poorly
conducted
treatment,
post-treatment
apical
periodontitis
coronal-root
perforation.
A
20-year-old
female
patient
with
radiographic
evidence
perforation
was
submitted
retreatment.
In
addition
procedures,
0.05%
methylene
blue
used
3-minutes
irradiation
period.
Ga-Al-Ar
diode
laser
attached
an
optical
fiber
diameter
365
μm
applied
by
using
90
s
time,
100
mW
power
9
J
energy.
conclusion,
associated
performed
technological
devices
represents
positive
impact
periapical
tissues
healing
teeth
furcation
Journal of Oral and Maxillofacial Pathology,
Год журнала:
2024,
Номер
28(4), С. 665 - 671
Опубликована: Окт. 1, 2024
In
recent
years,
Candida
albicans
has
emerged
as
a
significant
opportunistic
pathogen,
causing
various
infections,
particularly
in
immunocompromised
geriatric
individuals.
One
of
the
major
hindrances
managing
infections
lies
its
potential
to
develop
and
survive
biofilms,
which
demonstrate
resistance
conventional
antifungal
therapies,
thereby
complicating
treatment
strategies.
While
clove
oil
shown
promising
results
agent,
specific
anti-biofilm
effects
against
biofilms
remain
relatively
underexplored.
Therefore,
there
is
need
for
comprehensive
review
evaluate
existing
literature
on
properties
mechanisms
action
biofilms.
Such
will
provide
valuable
insights
into
therapeutic
applications
combating
biofilm-associated
infections.
This
enable
us
infer
understand
albicans.
systematic
aims
determine
efficacy
was
registered
'PROSPERO'
(CRD42024524134)
followed
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
guidelines.
The
searches
used
Google
Scholar,
PubMed,
Science
Direct
databases.
All
original
studies
published
English
from
2004
2023
were
included.
From
37
found
online,
only
four
reviewed.
Results
showed
that
had
activity
when
assessed
Our
provides
oil's
agent
Clove
also
represents
avenue
future
research
development
