Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 28, 2023
Abstract
Background:
Recent
studies
have
suggested
an
association
between
gut
microbiota
(GM)
and
venous
thromboembolism
(VTE).
However,
observational
cannot
indicate
causality
population-level
with
a
higher
evidence
level
for
are
lacking.
Therefore,
our
study
aimed
to
explore
the
causal
of
GM
VTE.
Methods:
This
utilized
summary-level
data
respective
genome-wide
196
microbial
taxa
Two-sample
Mendelian
randomization
(MR)
design
was
deployed
comprehensively
sensitive
analyses
were
followed
validate
robustness
results.
We
used
inverse-variance
weighted
(IVW)
method,
median
mode
simple
MR-Egger
regression,
intercept
test,
Cochrane’s
Q-test,
outlier
leave-one-out
analysis
as
primary
analysis.
Results:
identified
suggestive
associations
17
bacterial
traits
risk
Porphyromonadaceae
(IVW
odds
ratio
(OR):
1.3729,
p=0.0035)
Cyanobacteria
OR:
1.2151,
p=0.0048)
associated
increased
Three
(Eubacteriumrectalegroup
1.0038,
p=0.0278),
Coprococcus2
1.0041,
p
=
0.0063),
LachnospiraceaeUCG001
p=0.0009)
predicted
play
role
in
enhancing
encompassing
deep
vein
thrombosis.
And
three
(Christensenellaceae
1.0023,
p=0.0497),
Streptococcaceae
1.0031,
p=0.0279),
Victivallaceae
1.0014,
p=0.0493)
positively
pulmonary
embolism.
Conclusions:
specific
on
VTE,
which
may
provide
new
ideas
theoretical
basis
prevention
treatment
VTE
future.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 17, 2024
Abstract
Mounting
data
hints
that
the
gut
microbiota's
role
may
be
pivotal
in
understanding
emergence
of
psoriasis.
However,
discerning
a
direct
causal
link
is
yet
elusive.
In
this
exploration,
we
adopted
Mendelian
randomization
(MR)
strategy
to
probe
prospective
interplay
between
gut's
microbial
landscape
and
predisposition
Genetic
markers
acting
as
instrumental
variables
for
microbiota
were
extrapolated
from
genome-wide
association
study
(GWAS)
encompassing
18,340
individuals.
A
separate
GWAS
yielded
summary
psoriasis,
which
covered
337,159
patients
433,201
control
subjects.
The
primary
analysis
hinged
on
inverse
variance
weighting
(IVW).
Additional
methods
like
weighted
median
approach
MR-Egger
regression
employed
validate
integrity
our
findings.
Intriguing
correlations
emerged
psoriasis
risk
eight
specific
bacterial
traits.
To
illustrate:
Mollicutes
presented
an
odds
ratio
(OR)
1.003
with
95%
confidence
interval
(CI)
spanning
1.001–1.005
(p
=
0.016),
while
family.
Victivallaceae
revealed
OR
0.998
CI
values
0.997
0.999
0.023).
Eubacterium
(coprostanoligenes
group)
0.994
0.027).
(fissicatena
0.996
0.005).
Holdemania
1.001
1–1.003
0.034).
Lachnospiraceae
(NK4A136
0.995
0.046).
Lactococcus
0.008).
Tenericutes
1.006
0.016).
Sensitivity
these
features
congruent
outcomes,
reinforcing
statistically
significant
ties
entities
This
comprehensive
underscores
emerging
evidence
pointing
towards
plausible
nexus
diverse
onset
It
beckons
further
research
unravel
intricacies
how
constituents
might
sway
psoriasis's
pathogenesis.
European Clinical Respiratory Journal,
Год журнала:
2025,
Номер
12(1)
Опубликована: Фев. 26, 2025
Background
and
aim
The
association
of
the
gut
microbiota
to
chronic
obstructive
pulmonary
disease
(COPD)
phenotypes
is
underexplored.
We
aimed
compare
stool
samples
from
patients
with
COPD
subjects
without
relate
findings
emphysema
status,
exacerbation
rate,
blood
eosinophil
levels,
symptom
score,
lung
function.
International Journal of COPD,
Год журнала:
2024,
Номер
Volume 19, С. 643 - 653
Опубликована: Март 1, 2024
Background:
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
respiratory
disorder
with
complex
etiology
involving
genetic
and
environmental
factors.
The
dysbiosis
of
gut
microbiota
has
been
implicated
in
COPD.
Mendelian
Randomization
(MR)
provides
tool
to
investigate
causal
links
using
variants
as
instrumental
variables.
This
study
aims
employ
MR
analysis
explore
the
relationship
between
microbiota,
lung
function,
Methods:
We
utilized
genome-wide
association
(GWAS)
data
from
MiBioGen,
UK
Biobank
FinnGen,
which
were
related
microbial
taxa,
function
parameters
including
forced
vital
capacity
one
second
(FEV
1
),
(FVC),
percentage
predicted
FEV
%pred),
well
GWAS
for
was
conducted
assess
effects
on
risk
Sensitivity
examine
stability
relationships.
Multiple
testing
reverse
employed
evaluate
robustness
these
Results:
Using
IVW
method,
64
correlations
identified.
Through
conducting
sensitivity
analysis,
multiple
testing,
we
identified
14
robust
stable
bacterial
taxa
that
showed
positive
included
Desulfovibrionaceae
,
Erysipelotrichales,
Desulfovibrionales,
Clostridiales,
Clostridia,
Deltaproteobacteria
Erysipelotrichia
while
Selenomonadales
Negativicutes
negative
function.
abundance
Holdemanella
positively
correlated
COPD,
FamilyXIII
exhibited
correlation
Conclusion:
Several
discovered
have
offering
potential
insights
into
development
probiotics.
presence
negatively
COPD
emphasized
impact
health.
Keywords:
gut-lung
axis,
randomization
The
current
studies
have
shown
that
the
occurrence
and
development
of
chronic
obstructive
pulmonary
disease
(COPD)
are
closely
related
to
changes
in
gut
health
its
microenvironment,
even
some
diseases
significant
clinical
correlation
with
COPD.
dysbiosis
microbiota
observed
COPD
patients
also
suggests
a
potential
bidirectional
interaction
between
lung.
Communication
lung
may
occur
through
circulating
inflammatory
cells,
microbial
metabolites,
mediators,
but
mechanism
communication
is
still
under
study.
Therefore,
more
research
needed
this
area.
In
review,
we
summarize
recent
animal
models
on
role
gut-lung
axis
mechanisms,
so
as
provide
ideas
for
further
field.
addition,
summarized
negative
effects
medication
risk
factors
proposed
prevention
treatment
strategies.
Developmental Dynamics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
Sonic
Hedgehog
(SHH)
is
an
evolutionarily
conserved
signaling
pathway
essential
for
embryonic
development,
tissue
homeostasis,
and
tumorigenesis.
Aberrant
activation
of
the
SHH
induces
various
types
cancer
different
immune
dysregulation.
extremely
important
morphogen
during
lung
as
it
regulates
interaction
between
epithelial
mesenchymal
transitions
(EMT)
in
airways.
Cigarette
smoking
triggers
EMT
activates
pathway,
which
leads
to
damage
development
diseases,
such
COPD,
a
smoker's
disease.
also
directs
gut–lung
axis
(GLA)
formation
via
epithelial–mesenchymal
signaling.
The
abruption
or
alteration
GLA
responsible
COPD
pathogenesis.
In
this
review,
we
elucidate
overview
its
inhibitor
HHIP,
SHH's
prominence
dysregulation
pathogenesis
link
with
clinical
features.
We
provide
insights
into
linked
nicotine
their
influence
on
Microbiology Spectrum,
Год журнала:
2024,
Номер
12(7)
Опубликована: Май 24, 2024
Chronic
obstructive
pulmonary
disease
(COPD)
is
one
of
the
primary
causes
mortality
and
morbidity
worldwide.
The
gut
microbiome,
particularly
bacteriome,
has
been
demonstrated
to
contribute
progression
COPD.
However,
influence
virome
on
pathogenesis
COPD
rarely
studied.
Recent
advances
in
viral
metagenomics
have
enabled
rapid
discovery
its
remarkable
role
In
this
study,
deep
sequencing
fecal
virus-like
particles
bacterial
16S
rRNA
was
performed
92
subjects
from
China
characterize
alterations
Lower
richness
diversity
were
observed
compared
with
healthy
individuals.
Sixty-four
species,
including
The Journal of Headache and Pain,
Год журнала:
2024,
Номер
25(1)
Опубликована: Ноя. 11, 2024
The
gut
microbiota
may
be
involved
in
neuropathic
pain.
However,
the
causal
association
between
and
pain
remains
unclear.
Whether
immune
cells
inflammatory
factors
mediate
pathway
from
to
has
not
been
elucidated.
We
obtained
summary
data
of
412
microbiota,
731
cells,
91
factors,
five
types
(drug-induced
neuropathy,
postherpetic
neuralgia,
sciatica,
trigeminal
unspecified
neuralgia)
large-scale
genome-wide
study
(GWAS)
datasets
FinnGen
database.
used
bidirectional
Mendelian
randomization
(MR)
analysis
explore
Additionally,
we
conducted
a
mediation
identify
whether
act
as
mediators
within
these
relationships.
Our
revealed
30
relationships
26
bacterial
taxa
pain,
including
four
associated
with
drug-induced
six
eight
seven
neuralgia.
Moreover,
identified
35
abundances
causally
reverse
MR
showed
no
evidence
causality
Mediation
demonstrated
that
cell
phenotype
"HLA-DR++
monocyte
%
leukocyte"
mediated
relationship
p_Proteobacteria
sciatica
proportion
36.15%
(P
=
0.038),
whereas
"CD11c
on
CD62L+
myeloid
dendritic
cell"
assimilatory
sulfate
reduction
neuralgia
27.90%
0.041).
This
several
specific
various
subtypes.
two
potential
pathways
Abstract
Global
average
life
expectancy
has
steadily
increased
over
the
last
several
decades
and
is
projected
to
reach
~
77
years
by
2050.
As
it
stands,
number
of
people
>
60
currently
outnumbers
children
younger
than
5
years,
2050,
anticipated
that
global
population
aged
will
double,
surpassing
2.1
billion.
This
demographic
shift
in
our
expected
have
substantial
consequences
on
health
services
globally
due
disease
burden
associated
with
aging.
Osteoarthritis,
chronic
obstructive
pulmonary
disease,
diabetes,
cardiovascular
cognitive
decline
dementia
are
among
most
common
age-related
diseases
contribute
significantly
morbidity
mortality
population.
Many
these
been
linked
low-grade
systemic
inflammation
which
often
accompanies
Gastrointestinal
barrier
dysfunction,
also
known
as
“leaky
gut,”
shown
including
inflammatory
bowel
irritable
syndrome,
but
its
role
development
and/or
progression
during
aging
unclear.
review
outlines
current
literature
leaky
gut
aging,
how
might
inflammation,
links
between
gastrointestinal
provide
insight
into
a
potential
relationship
intestinal
inflammation.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 10, 2023
The
correlation
between
gut
microbiota
and
infections
has
garnered
significant
attention
in
previous
studies;
nevertheless,
our
understanding
of
the
causal
relationships
mechanisms
specific
microbial
species
remains
limited.This
study
aimed
to
employ
Mendelian
randomization
(MR)
using
single-nucleotide
polymorphisms
(SNPs)
genome-wide
association
(GWAS)
data
European
ancestry
explore
genetic-level
distinct
types
susceptibility
infections.
Our
analysis
encompassed
three
prevalent
infections:
intestinal
infections,
pneumonia,
urinary
tract
while
concurrently
examining
various
microbiota.We
identified
18
protective
microbiotas
alongside
13
associated
with
increased
infection
risk.
Particularly
noteworthy
are
certain
communities
capable
producing
butyrate,
such
as
Ruminococcaceae
Lachnospiraceae
families,
which
exhibited
both
favorable
unfavorable
effects.
Additionally,
we
observed
a
few
linked
susceptibility,
including
ErysipelotrichaceaeUCG003
(OR
=
0.13,
95%
CI:
0.054-0.33,
p
1.24E-05),
Collinsella
3.25,
2.00-5.27,
1.87E-06),
NB1n
1.24,
1.09-1.40,
1.12E-03).This
reveals
complex
findings
could
potentially
offer
new
avenues
for
exploring
prevention
treatment
strategies
infectious
diseases.
Aging,
Год журнала:
2024,
Номер
16(4), С. 3241 - 3256
Опубликована: Фев. 12, 2024
This
study
aimed
to
explore
the
profile
of
gut
microbiota
and
immunological
state
in
COPD
patients.
80
fecal
blood
samples
were
collected
from
40
patients
healthy
controls
(HC)
analyzed
with
16s-rRNA
gene
sequencing
immunofactor
omics
analysis
investigate
immunologic
factors
(IFs).
The
linear
discriminant
(LDA)
effect
size
(LefSe)
was
used
determine
biomarkerâs
taxa.
random
forest
LASSO
regression
executed
screen
IFs
develop
an
IFscore
model.
correlation
between
IFs,
along
diversity
microbiota,
evaluated
Spearman
analysis.
α
β
showed
that
composition
distribution
group
differed
HC
group.
7
differential
taxa
at
phylum
level
17
genus
found.
LefSe
screened
out
5
32
(up-regulated
27
down-regulated
IFs)
identified
two
groups,
(CCL3,
CXCL9,
CCL7,
IL2,
IL4)
construct
revealed
29
highly
related
enriched
16
pathways.
Furthermore,
relationship
very
close.
individuals.
Gut
immune
status
