International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9168 - 9168
Опубликована: Авг. 23, 2024
The
healthy
cervicovaginal
microbiota
is
dominated
by
various
Lactobacillus
species,
which
support
a
condition
of
eubiosis.
Among
their
many
functions,
vaginal
lactobacilli
contribute
to
the
maintenance
an
acidic
pH,
produce
antimicrobial
compounds,
and
modulate
host
immune
response
protect
against
bacterial
fungal
infections.
Increasing
evidence
suggests
that
these
beneficial
bacteria
may
also
confer
protection
sexually
transmitted
infections
(STIs)
caused
viruses
such
as
human
papillomavirus
(HPV),
immunodeficiency
virus
(HIV)
herpes
simplex
(HSV).
Viral
STIs
pose
substantial
public
health
burden
globally,
causing
range
infectious
diseases
with
potentially
severe
consequences.
Understanding
molecular
mechanisms
exert
protective
effects
viral
paramount
for
development
novel
preventive
therapeutic
strategies.
This
review
aims
provide
more
recent
insights
into
intricate
interactions
between
STIs,
exploring
impact
on
microenvironment,
response,
infectivity
pathogenesis,
highlighting
potential
implications
interventions
clinical
management
Microbiomes
have
been
linked
to
oncogenesis,
e.g.
the
intestinal
microbiome
and
colon
cancer
or
HPV-associated
cervical
cancer.
A
connection
between
microbiomes
of
different
body
cavities
tumor
oncogenesis
was
shown.
The
gut
microbiome's
influence
on
bladder
established,
raising
question
whether
nearby
(rectum,
vagina)
also
due
their
proximity.
Considering
various
broader
microbial
components,
this
systematic
review
aims
investigate
differences
in
bladder,
vaginal,
microbiota-including
bacterial,
viral,
fungal
archaea-between
patients
with
healthy
controls.
Databases
(PubMed,
Scopus,
Embase)
were
searched
until
April
2022.
Three
types
studies
included:
"(1)
using
control
groups
(case-controlled
studies)
(2)
that
provided
information
presence
abundance
taxa
(3)
increased
decreased
and/or
groups.".
Risk
bias
assessed
Newcastle
Ottawa
Scale.
Fourteen
(695
samples:
403
cancer,
292
controls)
analyzed.
Bacterial
detected
at
least
two
studies,
genera
Geobacillus
Rubrobacter
more
frequently
patients;
while
Streptococcus
Roseomonas
prevalent
No
consistent
identified
across
stool
tissue
samples.
microbiota
show
significant
variation
studies.
Standardized
methods
expanded
investigations
into
viral
components
are
needed
clarify
role
Frontiers in Systems Biology,
Год журнала:
2025,
Номер
5
Опубликована: Апрель 16, 2025
Background
The
increasing
incidence
of
inflammatory
bowel
diseases
(IBD)
over
the
last
two
decades
has
prompted
need
to
create
new
types
therapeutic
interventions.
gut
microbiome
emerged
as
a
key
component
in
prognosis
and
pathophysiology
IBDs.
alteration
or
dysbiosis
been
shown
exacerbate
bacterial
composition
can
be
modulated
through
usage
probiotics,
prebiotics,
synbiotics.
These
interventions
induce
growth
beneficial
bacteria.
Additionally,
these
could
used
maintain
homeostasis,
reduce
inflammation
seen
morbidities,
strengthen
epithelial
barrier.
Methods
literature
review
was
conducted
October
2024
using
PubMed,
Scopus,
Google
Scholar
screening
for
recent
clinical
trials
addition
reviews
relevant
topic.
Aims
This
aims
summarize
synbiotics
IBD
patients
highlighting
their
potential
benefits
alleviating
symptoms
enhancing
quality
life.
Conclusion
Certain
probiotic
formulations
such
single
strain
ones
consisting
Lactobacillus,
mixed-strain
combinations
Lactobacillus
Bifidobacterium
,
prebiotic
compounds
fructooligosaccharides,
synbiotic
both
have
proven
effective
improving
clinical,
immunological,
symptomatic
aspects
disease
course.
While
promising,
findings
remain
inconclusive
due
inconsistent
study
designs,
small
sample
sizes,
varying
patient
responses.
emphasizes
larger,
well-controlled
determine
efficacy.
Journal of Current Research in Scientific Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Abstract
Probiotics
are
live
microorganisms
that,
when
administered
in
adequate
amounts,
confer
a
health
benefit
on
the
host.
Commonly
used
probiotics
humans
belong
to
genera
Bifidobacterium
,
Lactobacillus
Bacillus
Streptococcus
and
Saccharomyces
available
as
single
agents
or
combination.
They
have
been
for
treatment
of
several
conditions,
but
data
regarding
their
efficacy
often
inadequate.
There
is
some
evidence
use
bacterial
infections.
The
objective
this
narrative
review
present
status
prevention
infections,
along
with
possible
mechanisms
action
adverse
effects
related
use.
Information
was
obtained
through
literature
search
PubMed-indexed
articles
over
past
11
years
Google
search.
Based
our
findings,
we
concluded
that
may
be
more
useful
recurrent
infections
such
Clostridioides
difficile
infection
caused
by
antibiotics
rather
than
treating
This
could
provide
insights
guidance
physicians
appropriate
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9168 - 9168
Опубликована: Авг. 23, 2024
The
healthy
cervicovaginal
microbiota
is
dominated
by
various
Lactobacillus
species,
which
support
a
condition
of
eubiosis.
Among
their
many
functions,
vaginal
lactobacilli
contribute
to
the
maintenance
an
acidic
pH,
produce
antimicrobial
compounds,
and
modulate
host
immune
response
protect
against
bacterial
fungal
infections.
Increasing
evidence
suggests
that
these
beneficial
bacteria
may
also
confer
protection
sexually
transmitted
infections
(STIs)
caused
viruses
such
as
human
papillomavirus
(HPV),
immunodeficiency
virus
(HIV)
herpes
simplex
(HSV).
Viral
STIs
pose
substantial
public
health
burden
globally,
causing
range
infectious
diseases
with
potentially
severe
consequences.
Understanding
molecular
mechanisms
exert
protective
effects
viral
paramount
for
development
novel
preventive
therapeutic
strategies.
This
review
aims
provide
more
recent
insights
into
intricate
interactions
between
STIs,
exploring
impact
on
microenvironment,
response,
infectivity
pathogenesis,
highlighting
potential
implications
interventions
clinical
management
