Drought stress mitigation through bioengineering of microbes and crop varieties for sustainable agriculture and food security
Current Research in Microbial Sciences,
Год журнала:
2024,
Номер
7, С. 100285 - 100285
Опубликована: Янв. 1, 2024
Climate
change
and
agriculture
are
intrinsically
connected
sudden
changes
in
climatic
conditions
adversely
impact
global
food
production
security.
The
climate
change-linked
abiotic
stressors
like
drought
high
temperatures
resulting
crop
failure.
most
severe
stress
significantly
affect
the
stomatal
closure,
of
reactive
oxygen
species,
transpiration,
photosynthesis
or
other
physiological
processes
plant
morphology,
growth
yield.
Therefore,
there
is
an
exigent
need
for
cost
effective
eco-friendly
modern
technologies
to
induce
tolerance
plants
leading
climate-adapted
sustainable
agricultural
practices
sustained
production.
Among
many
options
being
pursued
this
regard,
use
promoting
microbes
(PGPMs)
approach
promote
resilience
better
productivity.
These
PGPMs
confer
resistance
via
various
direct
indirect
mechanisms
including
antioxidants,
enzymes,
exopolysaccharides,
modulation
phytohormones
level,
osmotic
adjustment
by
inducing
accumulation
sugars,
along
with
increases
nutrients,
water
uptake
photosynthetic
pigments.
However,
several
technological
ecological
challenges
limit
their
sometimes
treatment
beneficial
fails
produce
desired
results
under
field
conditions.
Thus,
development
synthetic
microbial
communities
host
mediated
microbiome
engineering
transgenic
capacity
express
traits
may
survival
present
review
critically
assesses
research
evidence
on
potentials
genes
as
develop
resilient
increased
Effective
collaboration
among
scientific
communities,
policymakers
regulatory
agencies
needed
create
strong
frameworks
that
both
regulate
utilization
agriculture.
Язык: Английский
An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of their Potent Metabolites: Recent Advancement
Applied Biochemistry and Biotechnology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Endophytic
fungi
represent
a
significant
renewable
resource
for
the
discovery
of
pharmaceutically
important
compounds,
offering
substantial
potential
new
drug
development.
Their
ability
to
address
growing
issue
resistance
has
drawn
attention
from
researchers
seeking
novel,
nature-derived
lead
molecules
that
can
be
produced
on
large
scale
meet
global
demand.
Recent
advancements
in
genomics,
metabolomics,
bioinformatics,
and
improved
cultivation
techniques
have
significantly
aided
identification
characterization
fungal
endophytes
their
metabolites.
Current
estimates
suggest
there
are
approximately
1.20
million
globally,
yet
only
around
16%
(190,000)
been
identified
studied
detail.
This
underscores
vast
untapped
pharmaceutical
research.
Research
increasingly
focused
transformation
bioactive
compounds
by
through
chemical
enzymatic
processes.
A
notable
example
is
anthraquinone
derivative
6-O-methylalaternin,
whose
cytotoxic
enhanced
addition
hydroxyl
group,
sharing
structural
similarities
with
its
parent
compound
macrosporin.
These
structure-bioactivity
studies
open
up
avenues
developing
safer
more
effective
therapeutic
agents
synthesizing
targeted
derivatives.
Despite
immense
promise,
challenges
remain,
particularly
large-scale
understanding
complexities
biosynthetic
pathways.
Additionally,
genetic
manipulation
optimized
metabolite
production
still
infancy.
Future
research
should
aim
overcome
these
limitations
focusing
efficient
methods
deeper
exploration
endophytes’
metabolic
capabilities
fully
harness
potential.
Graphical
Язык: Английский
Exploring stachydrine: from natural occurrence to biological activities and metabolic pathways
Frontiers in Plant Science,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 6, 2024
Stachydrine,
also
known
as
proline
betaine,
is
a
prominent
constituent
of
traditional
Chinese
herb
Leonurus
japonicus
,
renowned
for
its
significant
pharmacological
effects.
Widely
distributed
in
plants
like
and
Citrus
aurantium
well
various
bacteria,
stachydrine
serves
pivotal
physiological
functions
across
animal,
plant,
bacterial
kingdoms.
This
review
aims
to
summarizes
diverse
roles
mechanisms
addressing
cardiovascular
cerebrovascular
diseases,
neuroprotection,
anticancer
activity,
uterine
regulation,
anti-inflammatory
response,
obesity
management,
respiratory
ailments.
Notably,
exhibits
cardioprotective
effects
via
multiple
pathways
encompassing
anti-inflammatory,
antioxidant,
anti-apoptotic,
modulation
calcium
handling
functions.
Furthermore,
anti-cancer
properties
inhibit
proliferation
migration
numerous
cancer
cell
types.
With
bi-directional
regulatory
effect
on
function,
holds
promise
obstetrics
gynecology-related
disorders.
In
plants,
secondary
metabolite,
contributing
osmotic
pressure
nitrogen
fixation,
pest
resistance,
stress
response.
Similarly,
it
plays
crucial
osmoprotective
role,
facilitating
adaptation
high
environments.
addresses
ongoing
research
the
anabolic
metabolism
stachydrine.
While
biosynthetic
pathway
remains
incompletely
understood,
metabolic
well-established.
A
deeper
understanding
biosynthesis
significance
elucidating
mechanism
action,
advancing
study
plant
metabolism,
enhancing
drug
quality
control,
fostering
new
development
endeavors.
Язык: Английский
Effects of Serendipita indica on the Morphological and Physiological Characteristics of Agrostis stolonifera L. Under Drought Stress
C. M. Lin,
Wenxu Hu,
Xin Qin
и другие.
Agronomy,
Год журнала:
2025,
Номер
15(1), С. 234 - 234
Опубликована: Янв. 18, 2025
This
study
investigates
the
effect
of
Serendipita
indica
inoculation
on
growth,
structural
characteristics
leaf
epidermis,
photosynthetic
parameters,
and
antioxidant
osmoregulation
capacities
Agrostis
stolonifera
L.
under
different
drought
stresses
(normal
moisture
management:
at
70–75%
field
capacity,
low
drought:
55–60%
moderate
40–45%
severe
25–30%
capacity).
The
results
showed
that
with
S.
significantly
enhanced
growth
potential
A.
compared
to
uninoculated
controls,
then
stress
conditions,
alleviated
inhibition
development
stolonifera,
especially
mild
stresses.
These
improvements
were
evident
in
both
aboveground
underground
parts,
relative
water
content,
total
root
length,
surface
area
after
25
days
treatments.
Inoculated
plants
also
exhibited
higher
levels
pigments,
net
rate
(Pn),
stomatal
conductance
(Gs),
transpiration
(Tr)
conditions.
Additionally,
increased
activities
catalase
(CAT),
peroxidase
(POD),
ascorbate
(APX),
as
well
soluble
sugar,
protein,
proline
drought-stressed
non-stressed
In
addition,
increases
malondialdehyde
(MDA)
content
conductivity
(RC)
leaves
lower
inoculated
group
control
group.
conclusion,
symbiosis
promotes
stress,
likely
by
enhancing
photosynthesis,
osmoregulatory
substances,
enzyme
activities.
Язык: Английский
Leveraging endophytic fungi and multiomics integration for targeted drug discovery
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 277 - 293
Опубликована: Янв. 1, 2025
Язык: Английский
Endophytic Fungi: Taxonomy, Isolation, and Current Applications
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 22, 2024
This
chapter
is
a
revision
of
the
realm
endophytic
fungi,
focusing
on
how
to
approach
study
their
biodiversity
in
relation
distribution,
richness,
host
plant
defense
mechanisms,
chemistry,
and
metabolomic
profiles.
We
will
revise
current
isolation
identification
methods
available
such
as
culture-dependent
techniques
omics
approaches
including
both
targeted
functional
metagenomics,
comparison
give
holistic
view
fungal
biome.
Additionally,
we
discuss
biotechnological
potential
for
production
bioactive
natural
products
be
applied
protection
(against
nematodes,
insect
control),
soil
restoration,
or
disease
control
practices
based
microbial
antagonists.
Язык: Английский
Enhancing walnut growth and drought tolerance through Serendipita indica: focus on mitochondrial antioxidant defense
Feng-Ling Zheng,
Zuo-Ping Tan,
Yi Zhang
и другие.
Plant Growth Regulation,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Язык: Английский
Arbuscular mycorrhizal fungi and intercropping Vicia villosa mediate plant biomass, soil properties, and rhizosphere metabolite profiles of walnuts
Chemical and Biological Technologies in Agriculture,
Год журнала:
2024,
Номер
11(1)
Опубликована: Окт. 28, 2024
Intercropping
is
a
prevalent
soil
management
strategy
within
orchards,
whereas
it
unclear
how
inoculation
with
arbuscular
mycorrhizal
(AM)
fungi
and
intercropping
affect
tree
growth,
properties,
rhizosphere
metabolite
profiles.
This
study
investigated
the
effects
of
Diversispora
spurca
hairy
vetch
(Vicia
villosa)
on
biomass
production,
available
nutrients,
water-stable
aggregate
(WSA)
distribution,
phosphatase
activity,
secondary
profiles
in
walnuts
(Juglans
regia).
The
only
elevated
nitrate
N
levels
WSA
distribution
at
0.5–2
mm
size,
also
triggered
2159
differential
metabolites
(1378
up-regulated
781
down-regulated),
armillaramide
as
most
prominently
metabolite,
followed
by
substance
diminished
upon
D.
inoculation.
Conversely,
increased
walnut
biomass,
across
0.25
−
2
acid
neutral
activities,
well
2489
(897
1592
pteroside
D
being
highest
allowing
competitive
advantage
to
AM
plants
combating
pathogens.
Despite
significantly
suppressing
root
fungal
colonization
production
walnuts,
ammonium
WSAs
1–4
exhibiting
synergistic
effect.
Flavone
flavonol
biosynthesis
pyruvate
metabolism
were
simultaneously
involved
following
or
intercropping.
Co-application
1006
metabolites,
urocanic
although
decreased
inoculation,
suggesting
involvement
hyphae
histidine
uptake.
Under
intercropping,
elicited
418
implicated
flavonoid
pathways.
primarily
unsaturated
fatty
acids,
regardless
not,
implying
potential
increase
contents
kernels.
It
concluded
that
interactively
affected
attributes,
microenvironment.
Язык: Английский