Plant-Derived Antimicrobials and Their Crucial Role in Combating Antimicrobial Resistance

Antibiotics, Год журнала: 2024, Номер 13(8), С. 746 - 746

Опубликована: Авг. 9, 2024

Antibiotic resistance emerged shortly after the discovery of first antibiotic and has remained a critical public health issue ever since. Managing in clinical settings continues to be challenging, particularly with rise superbugs, or bacteria resistant multiple antibiotics, known as multidrug-resistant (MDR) bacteria. This rapid development compelled researchers continuously seek new antimicrobial agents curb resistance, despite shrinking pipeline drugs. Recently, focus shifted plants, fungi, lichens, endophytes, various marine sources, such seaweeds, corals, other microorganisms, due their promising properties. For this review, an extensive search was conducted across scientific databases, including PubMed, Elsevier, ResearchGate, Scopus, Google Scholar, encompassing publications from 1929 2024. review provides concise overview mechanisms employed by develop followed in-depth exploration plant secondary metabolites potential solution MDR pathogens. In recent years, interest plant-based medicines surged, driven advantageous However, additional research is essential fully understand action verify safety phytochemicals. Future prospects for enhancing use combating antibiotic-resistant pathogens will also discussed.

Язык: Английский

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Impact of Metabolites from Foodborne Pathogens on Cancer

Foods, Год журнала: 2024, Номер 13(23), С. 3886 - 3886

Опубликована: Дек. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Язык: Английский

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Effectiveness of a CuZnNi alloy in preventing microbial growth and biofilm architecture

Journal of Materials Research and Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Probiotic Consortium from Poultry Strains for Supporting Gut Immunity Against Pathogens

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107584 - 107584

Опубликована: Апрель 1, 2025

Язык: Английский

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Design, synthesis, and computational analysis (molecular docking, DFT, MEP, RDG, ELF) of diazepine and oxazepine sulfonamides: biological evaluation for in vitro and in vivo anti-inflammatory, antimicrobial, and cytotoxicity predictions

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Окт. 2, 2024

Язык: Английский

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Metagenomic and Culturomics Analysis of Microbial Communities within Surface Sediments and the Prevalence of Antibiotic Resistance Genes in a Pristine River: The Zaqu River in the Lancang River Source Region, China

Microorganisms, Год журнала: 2024, Номер 12(5), С. 911 - 911

Опубликована: Апрель 30, 2024

Microbial communities inhabiting sedimentary environments in river source regions serve as pivotal indicators of pristine ecosystems. While the correlation between antibiotic resistome and pathogenicity with core gut bacteria humans is well established, there exists a significant knowledge gap concerning interaction resistance genes (ARGs) human pathogenic (HPB) specific microbes basins, often referred to "terrestrial gut". Understanding microbial composition, including resident genetic elements such ARGs, HPB, Mobile Genetic Elements (MGEs), Virulence Factors (VFs), within natural habitats against backdrop global change, imperative. To address this gap, an enrichment-based culturomics complementary along metagenomics was conducted study characterize biobank provide preliminary ecological insights into profiling dissemination ARGs Lancang River Source Basin. Based on our findings, main stream Basin, 674 strains bacteria, comprising 540 under anaerobic conditions 124 aerobic conditions, were successfully isolated. Among these, 98 species identified known species, while 4 potential novel species. Of these 30 HPB relevant health. Additionally,

Язык: Английский

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Electrophysiological Insights into Antibiotic Translocation and Resistance: The Impact of Outer Membrane Proteins

Membranes, Год журнала: 2024, Номер 14(7), С. 161 - 161

Опубликована: Июль 20, 2024

The alarming rise of antibiotic resistance in Gram-negative bacteria has emerged as a major global health challenge. A key factor contributing to this crisis is the low permeability bacterial outer membrane, which acts barrier that prevents antibiotics from entering cell. Protein channels embedded membrane selectively regulate influx hydrophilic compounds, including antibiotics. To combat resistance, understanding molecular mechanisms governing through crucial. This knowledge towards elucidating their roles studing resistance. By compiling and analysing flux data multiple electrophysiological reversal potential experimental studies, involves measuring zero-current potentials corresponding single-channel conductance, we can calculate charged antibiotics/compounds across different channels. Through comprehensive synthesis, review aims advance our stimulate discussions about physicochemical factors influencing protein channels, ultimately enhancing area.

Язык: Английский

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Virulence Regulation in Plant-Pathogenic Bacteria by Host-Secreted Signals

Microbiological Research, Год журнала: 2024, Номер 288, С. 127883 - 127883

Опубликована: Авг. 24, 2024

Bacterial pathogens manipulate host signaling pathways and evade defenses using effector molecules, coordinating their deployment to ensure successful infection. However, host-derived metabolites as signals, critical role in regulating bacterial virulence requires further insights. Effective regulation of virulence, which is essential for pathogenic bacteria, involves controlling factors that enable colonization, defense evasion, tissue damage. This dynamic, influenced by environmental cues including signals from plants like exudates. Plant exudates, comprising diverse compounds released roots tissues, serve rich chemical affecting the behavior associated bacteria. nutrients act molecules are sensed through membrane-localized receptors intracellular response mechanisms review explains how different bacteria detect answer secreted gene expression. Our main emphasis exploring recognition process host-originated molecular sensors on cellular membranes pathways. encompasses insights into strains individually coordinate various distinct can positively or negatively regulate virulence. Furthermore, we explained interruption plant with perception dampen pathogen The intricate interplay between particularly recognize metabolic genes, portrays a crucial initial interaction leading profound influences infection outcomes. work will greatly aid researchers developing new strategies preventing treating infections.

Язык: Английский

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Synthesis and characterization of Azo-Azomethine derivatives bearing thiazole moiety: In vitro antimicrobial, in vitro and in vivo anti-inflammatory, and cytotoxicity assessment, accompanied by computational molecular docking, RDG, ELF, DFT, and MEP analysis

Journal of Molecular Structure, Год журнала: 2024, Номер 1318, С. 139294 - 139294

Опубликована: Июль 16, 2024

Язык: Английский

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Advancements in Green Nanoparticle Technology: Focusing on the Treatment of Clinical Phytopathogens

Biomolecules, Год журнала: 2024, Номер 14(9), С. 1082 - 1082

Опубликована: Авг. 28, 2024

Opportunistic pathogenic microbial infections pose a significant danger to human health, which forces people use riskier, more expensive, and less effective drugs compared traditional treatments. These may be attributed several factors, such as overusing antibiotics in medicine lack of sanitization hospital settings. In this context, researchers are looking for new options combat worrying condition find solution. Nanoparticles currently being utilized the pharmaceutical sector; however, there is persistent worry regarding their potential health due usage toxic chemicals, makes utilization nanoparticles highly hazardous eukaryotic cells. Multiple nanoparticle-based techniques now developed, offering essential understanding synthesis components that play crucial role producing anti-microbial nanotherapeutic pharmaceuticals. regard, green considered than other forms, providing avoiding extensive harm microbiome prevalent with existing procedures. This review article aims comprehensively assess current state knowledge on related antibiotic activity well assist treating opportunistic clinical phytopathogenic illnesses.

Язык: Английский

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