Plant-Derived Antimicrobials and Their Crucial Role in Combating Antimicrobial Resistance

Antibiotics, Journal Year: 2024, Volume and Issue: 13(8), P. 746 - 746

Published: Aug. 9, 2024

Antibiotic resistance emerged shortly after the discovery of first antibiotic and has remained a critical public health issue ever since. Managing in clinical settings continues to be challenging, particularly with rise superbugs, or bacteria resistant multiple antibiotics, known as multidrug-resistant (MDR) bacteria. This rapid development compelled researchers continuously seek new antimicrobial agents curb resistance, despite shrinking pipeline drugs. Recently, focus shifted plants, fungi, lichens, endophytes, various marine sources, such seaweeds, corals, other microorganisms, due their promising properties. For this review, an extensive search was conducted across scientific databases, including PubMed, Elsevier, ResearchGate, Scopus, Google Scholar, encompassing publications from 1929 2024. review provides concise overview mechanisms employed by develop followed in-depth exploration plant secondary metabolites potential solution MDR pathogens. In recent years, interest plant-based medicines surged, driven advantageous However, additional research is essential fully understand action verify safety phytochemicals. Future prospects for enhancing use combating antibiotic-resistant pathogens will also discussed.

Language: Английский

---

Impact of Metabolites from Foodborne Pathogens on Cancer

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

---

Design, synthesis, and computational analysis (molecular docking, DFT, MEP, RDG, ELF) of diazepine and oxazepine sulfonamides: biological evaluation for in vitro and in vivo anti-inflammatory, antimicrobial, and cytotoxicity predictions

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Language: Английский

---

Electrophysiological Insights into Antibiotic Translocation and Resistance: The Impact of Outer Membrane Proteins

Membranes, Journal Year: 2024, Volume and Issue: 14(7), P. 161 - 161

Published: July 20, 2024

The alarming rise of antibiotic resistance in Gram-negative bacteria has emerged as a major global health challenge. A key factor contributing to this crisis is the low permeability bacterial outer membrane, which acts barrier that prevents antibiotics from entering cell. Protein channels embedded membrane selectively regulate influx hydrophilic compounds, including antibiotics. To combat resistance, understanding molecular mechanisms governing through crucial. This knowledge towards elucidating their roles studing resistance. By compiling and analysing flux data multiple electrophysiological reversal potential experimental studies, involves measuring zero-current potentials corresponding single-channel conductance, we can calculate charged antibiotics/compounds across different channels. Through comprehensive synthesis, review aims advance our stimulate discussions about physicochemical factors influencing protein channels, ultimately enhancing area.

Language: Английский

---

Metagenomic and Culturomics Analysis of Microbial Communities within Surface Sediments and the Prevalence of Antibiotic Resistance Genes in a Pristine River: The Zaqu River in the Lancang River Source Region, China

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 911 - 911

Published: April 30, 2024

Microbial communities inhabiting sedimentary environments in river source regions serve as pivotal indicators of pristine ecosystems. While the correlation between antibiotic resistome and pathogenicity with core gut bacteria humans is well established, there exists a significant knowledge gap concerning interaction resistance genes (ARGs) human pathogenic (HPB) specific microbes basins, often referred to "terrestrial gut". Understanding microbial composition, including resident genetic elements such ARGs, HPB, Mobile Genetic Elements (MGEs), Virulence Factors (VFs), within natural habitats against backdrop global change, imperative. To address this gap, an enrichment-based culturomics complementary along metagenomics was conducted study characterize biobank provide preliminary ecological insights into profiling dissemination ARGs Lancang River Source Basin. Based on our findings, main stream Basin, 674 strains bacteria, comprising 540 under anaerobic conditions 124 aerobic conditions, were successfully isolated. Among these, 98 species identified known species, while 4 potential novel species. Of these 30 HPB relevant health. Additionally,

Language: Английский

---

Synthesis and characterization of Azo-Azomethine derivatives bearing thiazole moiety: In vitro antimicrobial, in vitro and in vivo anti-inflammatory, and cytotoxicity assessment, accompanied by computational molecular docking, RDG, ELF, DFT, and MEP analysis

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139294 - 139294

Published: July 16, 2024

Language: Английский

---

Virulence Regulation in Plant-Pathogenic Bacteria by Host-Secreted Signals

Microbiological Research, Journal Year: 2024, Volume and Issue: 288, P. 127883 - 127883

Published: Aug. 24, 2024

Bacterial pathogens manipulate host signaling pathways and evade defenses using effector molecules, coordinating their deployment to ensure successful infection. However, host-derived metabolites as signals, critical role in regulating bacterial virulence requires further insights. Effective regulation of virulence, which is essential for pathogenic bacteria, involves controlling factors that enable colonization, defense evasion, tissue damage. This dynamic, influenced by environmental cues including signals from plants like exudates. Plant exudates, comprising diverse compounds released roots tissues, serve rich chemical affecting the behavior associated bacteria. nutrients act molecules are sensed through membrane-localized receptors intracellular response mechanisms review explains how different bacteria detect answer secreted gene expression. Our main emphasis exploring recognition process host-originated molecular sensors on cellular membranes pathways. encompasses insights into strains individually coordinate various distinct can positively or negatively regulate virulence. Furthermore, we explained interruption plant with perception dampen pathogen The intricate interplay between particularly recognize metabolic genes, portrays a crucial initial interaction leading profound influences infection outcomes. work will greatly aid researchers developing new strategies preventing treating infections.

Language: Английский

---

Novel Halogenated Gabapentin-Derivative Introduction (GDCB), anti-Bacterial, anti-Fungal, and Neuronal Cell Toxicity Assessments

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141413 - 141413

Published: Jan. 1, 2025

Language: Английский

---

Synthesis of new dihydropyrimidine derivatives and investigation of their antimicrobial and DNA gyrase inhibitory activities

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(1)

Published: Jan. 1, 2025

Abstract Quinolone antibiotics are known for their antibacterial activity by inhibiting the enzyme DNA gyrase. Inspired mechanism, new compounds combining 1,4‐dihydropyrimidine, a quinolone isostere, with pyridine/pyrimidine rings were synthesized. These derivatives showed effects, likely through gyrase inhibition, as supported molecular docking and dynamics simulations. The synthesized compounds, 2‐[(5‐cyano‐6‐oxo‐6‐(pyridin‐4‐yl)‐1,6‐dihydropyrimidin‐2‐yl]‐ N ‐(benzothiazol‐2‐yl)‐acetamide ( 5a–5g ) 2‐[(5‐cyano‐6‐oxo‐6‐(pyridin‐4‐yl)‐1,6‐dihydropyrimidin‐2‐yl)thio]‐ ‐(thiazol‐2‐yl)acetamide 6a–6f ), evaluated activity. Compounds 5a , 6b 6c demonstrated significant bactericidal effects. Against Escherichia coli exhibited minimum inhibitory concentration (MIC) values of 1.95 0.97 µg/mL, respectively, comparable to standard drug. Compound also strong against faecalis . inhibition studies confirmed that inhibit enzyme, no supercoiled band was observed. findings highlight potential these agents. Future development could focus on optimizing structures enhanced activity, similar antibiotics.

Language: Английский

---

Antimicrobial and Antioxidant Properties of Oldenlandia corymbosa L. ethanolic extract: A Comprehensive Study with Molecular Docking and GC-MS Analysis

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42901 - e42901

Published: Feb. 1, 2025

Language: Английский

---