Precision prognostication in breast cancer: unveiling a long non-coding RNA-based model linked to disulfidptosis for tailored immunotherapeutic strategies

Aging, Год журнала: 2024, Номер unknown

Опубликована: Июнь 18, 2024

Background: Breast cancer, comprising 15% of newly diagnosed malignancies, poses a formidable global oncological challenge for women. The severity this malady stems from tumor infiltration, metastasis, and elevated mortality rates. Disulfidptosis, an emerging cellular demise mechanism, presents promising avenue precision therapy. Our aim was to construct prognostic framework centered on long non-coding RNAs (lncRNAs) associated with disulfidptosis, aiming guide the strategic use clinical drugs, enhance precision, advance immunotherapy prognosis assessment. Methods: We systematically analyzed TCGA-BRCA dataset identify disulfidptosis-linked lncRNAs. Employing co-expression analysis, we discerned significant relationships between disulfidptosis-associated genes Identified lncRNAs underwent univariate Cox regression validation through LASSO regression, culminating in identification eight signature using multivariate proportional risk model. Then, utilized selected build prediction models. Results: DAL model exhibited outstanding efficacy, establishing itself as autonomous determinant breast cancer prognosis. It adeptly differentiated low high-risk patient cohorts, individuals experiencing significantly abbreviated survival durations. Notably, these cohorts displayed marked discrepancies markers microenvironment attributes. Conclusions: has performed well assessment by combining it other traditional indicators Nomogram plots gene expression data calculate patients' disease scores. This approach provides new ideas decision support personalized treatment decisions patients different levels.

Язык: Английский

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Mitochondria: a crucial factor in the progression and drug resistance of colorectal cancer

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 23, 2024

Colorectal cancer (CRC), as one of the malignant tumors with highest incidence and mortality rates worldwide in recent years, originating primarily from mucosal tissues colon or rectum, has potential to rapidly develop into invasive cancer. Its pathogenesis is complex, involving a multitude factors including genetic background, lifestyle, dietary habits. Early detection treatment are key improving survival for patients CRC. However, pervasive problem that can become severely resistant treatment, which greatly increases complexity challenge treatment. Therefore, unraveling overcoming resistance CRC focus research. Mitochondria, energy centers cell, play crucial role cellular metabolism, supply, apoptosis process. In CRC, Mitochondrial dysfunction not only impairs normal cell function but also promotes tumor resistance. deep understanding relationship between mitochondrial mechanisms development, well by it chemotherapy drugs, development targeted therapies, enhancing drug efficacy, outcomes quality life patients.

Язык: Английский

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Exploring copper metabolism-induced cell death in gastric cancer: a single-cell RNA sequencing study and prognostic model development

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 27, 2024

Язык: Английский

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Machine learning-based prediction of gastroparesis risk following complete mesocolic excision

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 27, 2024

Язык: Английский

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Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155657 - 155657

Опубликована: Окт. 16, 2024

Язык: Английский

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