Integrating multi-omics techniques and in vitro experiments reveals that GLRX3 regulates the immune microenvironment and promotes hepatocellular carcinoma cell proliferation and invasion through iron metabolism pathways DOI Creative Commons
Yang Li, Yuan Chen, Yang Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Hepatocellular carcinoma (HCC) is a common malignancy worldwide, and its development closely related to abnormalities in iron metabolism. This study aims systematically analyze changes metabolism the tumor microenvironment of HCC using single-cell sequencing technology, investigate potential mechanisms by which regulation affects survival liver cancer patients.

Language: Английский

Machine learning-based prediction of gastroparesis risk following complete mesocolic excision DOI Creative Commons
Wei Wang,

Zhu Yan,

Zhanshuo Zhang

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 27, 2024

Language: Английский

Citations

0
Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment DOI

Abida Abida,

Abdulmalik S A Altamimi,

Nehmat Ghaboura

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155657 - 155657

Published: Oct. 16, 2024

Language: Английский

Citations

0
Deciphering the role of NcRNAs in Pancreatic Cancer immune evasion and drug resistance: a new perspective for targeted therapy DOI Creative Commons
Yu Gong,

Desheng Gong,

S Y Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 1, 2024

Pancreatic cancer (PC) is a very aggressive digestive system tumor, known for its high mortality rate, low cure survival rate and poor prognosis. In particular, pancreatic ductal adenocarcinoma (PADC), which accounts more than 90% of PC cases, has an overall 5-year only 5%, extremely critical situation. Early detection effective treatment difficult, leads many patients to despair. the current medical context, targeted therapy, as important strategy treatment, expected. However, problems immune escape drug resistance in have become two major obstacles that are difficult be overcome by therapy. How break through these difficulties key issue solved field recent years, non-coding RNAs (ncRNAs) continued heat up research. NcRNAs play pivotal role gene regulation, cell differentiation, development, disease processes, their roles genesis, therapeutic response been gradually revealed. More importantly, ncRNAs advantages targets, such specificity side effects, making them new favorite Therefore, aim this paper provide ideas methods therapy reviewing mechanism action four (circRNAs, lncRNAs, miRNAs, siRNAs) both PC. It expected way can found in-depth study ncRNA, bringing ray hope patients.

Language: Английский

Citations

0
Multi-omics analysis reveals the role of the autophagy-related gene AGT in chemotherapy resistance in colorectal cancer and the therapeutic potential of its inhibitors DOI Creative Commons

Wenjiao Cai,

Xiang Tao, Xiaoli Liu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 18, 2024

Autophagy is a crucial mechanism for maintaining cellular homeostasis and responding to environmental stress, it closely linked tumor drug resistance. Through multi-omics analysis, this study explores the expression patterns, functions, potential role of autophagy-related gene Angiotensinogen (AGT) in colorectal cancer (CRC), particularly relation chemotherapy This first compared AGT between CRC normal tissues using GTEx TCGA databases. Differences were assessed Wilcoxon Rank Sum Tests, prognostic impact was evaluated through univariate Cox survival analysis meta-analysis. Functional enrichment performed limma fgsea packages. Drug sensitivity conducted based on CTRP database, while immune infiltration CIBERSORT ESTIMATE methods. Spatial transcriptomic characteristics explored 10x Visium technology deconvolution investigate correlation levels cell content.scRNA-seq data from sourced Tumor Immune Single Cell Hub (TISCH).Functional annotation with Single-sample set (SSGSEA), pseudotime Monocle 2 mapped their developmental trajectories. The inhibitors treatment analyzed drug-target Mendelian randomization.Finally, Phenome-Wide Association Study (PheWAS) evaluate genetic associations side effects inhibitors. significantly higher associated shorter recurrence-free (RFS). signaling pathways markedly enriched high group. positively correlated resistance chemotherapeutic agents such as gemcitabine, cisplatin, paclitaxel, 5-fluorouracil. revealed that predominantly expressed malignant regions. Single-cell identified 21 distinct subpopulations across 13 major types. samples, especially fibroblast C6 subpopulation. Tumor-related C1, C5, C6, C8 subpopulations. Pseudotime these subpopulations, terminal stages.Drug-target randomization indicated negative causal relationship risk both heart failure(ORdrug = 0.950, 95% CI, 0.912–0.990; P 0.014) CRC(ORdrug 0.874, CI: 0.792–0.964; 0.007).PheWAS showed no other traits, indicating its specificity low effects. Elevated chemotherapy, inhibition may offer therapeutic avenue cancer.

Language: Английский

Citations

0
Integrating multi-omics techniques and in vitro experiments reveals that GLRX3 regulates the immune microenvironment and promotes hepatocellular carcinoma cell proliferation and invasion through iron metabolism pathways DOI Creative Commons
Yang Li, Yuan Chen, Yang Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Hepatocellular carcinoma (HCC) is a common malignancy worldwide, and its development closely related to abnormalities in iron metabolism. This study aims systematically analyze changes metabolism the tumor microenvironment of HCC using single-cell sequencing technology, investigate potential mechanisms by which regulation affects survival liver cancer patients.

Language: Английский

Citations

0