Endophyte-mediated synthesis of silver nanoparticles and their biological applications

Applied Microbiology and Biotechnology, Год журнала: 2019, Номер 103(6), С. 2551 - 2569

Опубликована: Фев. 5, 2019

Язык: Английский

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Promising Antiviral, Antimicrobial and Therapeutic Properties of Green Nanoceria

Nanomedicine, Год журнала: 2020, Номер 15(5), С. 467 - 488

Опубликована: Фев. 1, 2020

Aim: To demonstrate synthesis of cerium oxide nanoparticles (CeO2 NPs) by a green method using Hyphaene thebaica, and investigate their therapeutic applications. Materials & methods: Structural, vibrational luminescent properties were established x-ray diffraction, Fourier transformed infrared spectroscopy, Raman ultraviolet absorption selected area electron microscopy photolumincence spectroscopy. Therapeutic different in vitro assays. Results: CeO2 NPs determined to be crystalline nature with grain size approximately 14 nm. They had characteristic Ce-O vibration at 481 cm-1. Photoluminescence spectra revealed broad bands 463 600 ζ potential was recorded as -17.2 mV. Potent antimicrobial antiviral hemocompatibility reported. Conclusion: Biosynthesized multifunctional properties.

Язык: Английский

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Microbes-mediated synthesis strategies of metal nanoparticles and their potential role in cancer therapeutics

Seminars in Cancer Biology, Год журнала: 2021, Номер 86, С. 693 - 705

Опубликована: Июнь 9, 2021

Язык: Английский

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Floral extracts-mediated green synthesis of NiO nanoparticles and their diverse pharmacological evaluations

Journal of Biomolecular Structure and Dynamics, Год журнала: 2020, Номер 39(11), С. 4133 - 4147

Опубликована: Июнь 22, 2020

Biosynthesis has emerged as an exciting interface for assembling multifunctional metal oxide nanoparticles diverse medicinal applications. Herein, biogenic nickel (NiO-NPs) is synthesized by using floral extracts of Callistemon viminalis (C. viminalis) a low cost, ecofriendly reducing and stabilizing agent. NiO-NPs were annealed at 300 °C, 400 °C 500 while their physiochemical properties established HR-SEM/TEM, UV, XRD, FTIR, EDS, SAED SQUID techniques. Particle size decreased with increase in annealing temperatures. Magnetization curves indicated superparamagnetic behavior the K. Highly crystalline obtained after used biomedical The anti-leishmanial activity on Leishmania tropica promastigotes (KMH-23) anticancer HepG2 (RCB1648) revealed excellent inhibition potential IC50 37.21 µg/mL 47 µg/mL, respectively. Significant antibacterial effect was observed against Klebsiella pneumonia Proteus vulgaris MIC's 12.5 each. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE) α-glucosidase inhibitory comparable positive control drugs. Moderate antioxidant activities observed. to be hemolytic (30%) higher dose (1000 µg/mL). Overall, nature that can explored applications.Communicated Ramaswamy H. Sarma

Язык: Английский

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In Silico Molecular Docking Analysis of Karanjin against Alzheimer’s and Parkinson’s Diseases as a Potential Natural Lead Molecule for New Drug Design, Development and Therapy

Molecules, Год журнала: 2022, Номер 27(9), С. 2834 - 2834

Опубликована: Апрель 29, 2022

Parkinson's disease (PD) and Alzheimer's (AD) are neurodegenerative disorders that have emerged as among the serious health problems of 21st century. The medications currently available to treat AD PD limited efficacy associated with side effects. Natural products one most vital conservative sources medicines for treating neurological problems. Karanjin is a furanoflavonoid, isolated mainly from

Язык: Английский

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Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer’s disease: Current trends and future perspectives

Frontiers in Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Авг. 4, 2022

Alzheimer's disease (AD), the most common form of dementia, is a progressive and multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due to increase in life expectancy world population, including developing countries, AD, incidence rises dramatically with age, at forefront among diseases. Moreover, definitive cure not yet within reach, imposing substantial medical public health burdens every latitude. Therefore, effort devise novel effective therapeutic strategies still paramount importance. Genetic, functional, structural biochemical studies all indicate that new efficacious drug delivery interfere different levels various cellular molecular targets. Over last few decades, development nanomedicine preclinical stage has shown progress fast pace, thus paving way for its potential impact on human improving prevention, diagnosis, treatment age-related disorders, AD. Clinical translation nano-based therapeutics, despite current limitations, may present important advantages innovation be exploited neuroscience field as well. In this state-of-the-art review article, we promising applications polymeric nanoparticle-mediated bypassing blood-brain barrier AD models boost pharmacological safety efficacy. particular, strategic chemical functionalization nanocarriers could successfully employed treating thoroughly described. Emphasis also placed nanotheranostics both diagnostic tool targeted treatments. Our highlights emerging role management providing readers an overview nanostrategies currently available develop future against chronic disease.

Язык: Английский

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Alzheimer’s Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms

Molecules, Год журнала: 2022, Номер 27(20), С. 6804 - 6804

Опубликована: Окт. 11, 2022

Saponins are triterpenoid or steroidal glycosides and an important group of naturally occurring compounds plant origin. They exhibit diverse pharmacological potentials including radical scavenging, as well neuroprotective, anti-diabetic anti-inflammatory activities, owing to their chemical scaffolds. consist aglycone part (non-sugar) a glycone (sugar) have at least one glycosidic (C–O sugar bond) linkage present between the mostly C-3. On basis part, saponins classified into glycosides, steroid alkaloid glycosides. neuroprotective activities against various disorders central nervous system (CNS) stroke, Alzheimer’s disease (AD), Huntington’s (HD) Parkinson’s (PD). mediate therapeutic effects by modulation pathological targets. This study highlights mechanisms free signaling pathways, activation neurotrophic factors, neurotransmitters, inhibition BACE1 enzyme tau hyper-phosphorylation. The concludes that considerable efficacy targets neurological disorders, especially AD, might be source leads neurodegenerative disorders.

Язык: Английский

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Nano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: an up-to-date perspective

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Дек. 13, 2023

Neurons and their connecting axons gradually degenerate in neurodegenerative diseases (NDs), leading to dysfunctionality of the neuronal cells eventually death. Drug delivery for treatment effected nervous system is notoriously complicated because presence natural barriers, i.e., blood-brain barrier blood cerebrospinal fluid barrier. Palliative care currently standard many diseases. Therefore, programs that target disease's origin rather than its symptoms are recommended. Nanotechnology-based drug platforms offer an innovative way circumvent these obstacles deliver medications directly central system, thereby enabling several common neurological problems, Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis. Interestingly, combination nanomedicine gene therapy enables targeting selective mutant genes responsible progression NDs, which may provide a much-needed boost struggle against Herein, we discussed various obstacles, followed by detailed insight into recently developed techniques restore function via differentiation neural stem cells. Moreover, comprehensive background on role controlling neurogenesis explained. Additionally, numerous phytoconstituents with neuroprotective properties molecular targets identification management NDs also deliberated. Furthermore, ongoing clinical trials marketed products provided this manuscript.

Язык: Английский

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Photobiomodulation in Alzheimer’s Disease—A Complementary Method to State-of-the-Art Pharmaceutical Formulations and Nanomedicine?

Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 916 - 916

Опубликована: Март 11, 2023

Alzheimer’s disease (AD), as a neurodegenerative disorder, usually develops slowly but gradually worsens. It accounts for approximately 70% of dementia cases worldwide, and is recognized by WHO public health priority. Being multifactorial disease, the origins AD are not satisfactorily understood. Despite huge medical expenditures attempts to discover new pharmaceuticals or nanomedicines in recent years, there no cure many successful treatments available. The current review supports introspection on latest scientific results from specialized literature regarding molecular cellular mechanisms brain photobiomodulation, complementary method with implications AD. State-of-the-art pharmaceutical formulations, development nanoscale materials, bionanoformulations applications perspectives highlighted. Another goal this was speed transition completely paradigms multi-target management AD, facilitate remodeling through therapeutic models high-tech light lasers integrative nanomedicine future. In conclusion, insights interdisciplinary approach, including photobiomodulation (PBM) applied human clinical trials, combined drug delivery systems easily overcome protective barriers, could open avenues rejuvenate our central nervous system, most fascinating complex organ. Picosecond transcranial laser stimulation be successfully used cross blood-brain barrier together nanotechnologies, therapy. Original, smart targeted multifunctional solutions nanodrugs may soon developed treat

Язык: Английский

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Mechanistic insights and emerging therapeutic stratagems for Alzheimer’s disease

Ageing Research Reviews, Год журнала: 2024, Номер 97, С. 102309 - 102309

Опубликована: Апрель 13, 2024

Язык: Английский

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