Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease

Revue Neurologique, Год журнала: 2019, Номер 175(10), С. 724 - 741

Опубликована: Сен. 11, 2019

Язык: Английский

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Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(9), С. 3165 - 3165

Опубликована: Апрель 30, 2020

The exact connection between Alzheimer’s disease (AD) and type 2 diabetes is still in debate. However, poorly controlled blood sugar may increase the risk of developing Alzheimer’s. This relationship so strong that some have called “diabetes brain” or “type 3 (T3D)”. Given more recent studies continue to indicate evidence linking T3D with AD, this review aims demonstrate AD based on fact both processing amyloid-β (Aβ) precursor protein toxicity clearance Aβ are attributed impaired insulin signaling, resistance mediates dysregulation bioenergetics progress AD. Furthermore, insulin-related therapeutic strategies suggested succeed development therapies for by slowing down their progressive nature even halting future complications.

Язык: Английский

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Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

Biomedicine & Pharmacotherapy, Год журнала: 2020, Номер 131, С. 110622 - 110622

Опубликована: Авг. 17, 2020

Propolis, a resinous material produced by honey bees from plant exudates, has long been used in traditional herbal medicine and is widely consumed as health aid immune system booster. The COVID-19 pandemic renewed interest propolis products worldwide; fortunately, various aspects of the SARS-CoV-2 infection mechanism are potential targets for compounds. entry into host cells characterized viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) serine protease TMPRSS2. This involves PAK1 overexpression, which kinase that mediates coronavirus-induced lung inflammation, fibrosis, suppression. Propolis components have inhibitory effects on ACE2, TMPRSS2 signaling pathways; addition, antiviral activity proven vitro vivo. In pre-clinical studies, promoted immunoregulation pro-inflammatory cytokines, including reduction IL-6, IL-1 beta TNF-α. monocytes macrophages, well Jak2/STAT3, NF-kB, inflammasome pathways, reducing risk cytokine storm syndrome, major mortality factor advanced disease. also shown promise an treatment comorbidities particularly dangerous patients, respiratory diseases, hypertension, diabetes, cancer. Standardized consistent bioactive properties now available. Given current emergency caused limited therapeutic options, presented promising relevant option safe, easy to administrate orally readily available natural supplement functional food.

Язык: Английский

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Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study

PLoS ONE, Год журнала: 2021, Номер 16(12), С. e0260853 - e0260853

Опубликована: Дек. 10, 2021

Computer aided toxicity and pharmacokinetic prediction studies attracted the attention of pharmaceutical industries as an alternative means to predict potential drug candidates. In present study, in-silico properties (ADME), drug-likeness, profiles sixteen antidiabetic flavonoids that have ideal bidentate chelating sites for metal ion coordination were examined using SwissADME, Pro Tox II, vNN ADMETlab web tools. Density functional theory (DFT) calculations also employed calculate quantum chemical descriptors compounds. Molecular docking against human alpha amylase conducted. The results compared with control drugs, metformin acarbose. drug-likeness showed all flavonoids, except myricetin, found obey Lipinski's rule five their like molecular nature. Pharmacokinetically, chrysin, wogonin, genistein, baicalein, apigenin best absorption profile intestinal (HIA) value ≥ 30%, other flavonoids. Baicalein, butein, ellagic acid, eriodyctiol, Fisetin quercetin predicted show carcinogenicity. flavonoid derivatives considered in this study are be suitable molecules CYP3A probes, eriodyctiol which interacts P-glycoprotein (p-gp). toxicological endpoints analysis median lethal dose (LD50) values range from 159-3919 mg/Kg, baicalein mutagenic whereas butein is only immunotoxin. significant interaction (-7.5 -8.3 kcal/mol) studied binding pocket α-amylase protein relative crucial amino acids Asp 197, Glu 233, Trp 59, Tyr 62, His 101, Leu 162, Arg 195, 299 165. Chrysin was a ligand high lipophilicity 84.6% (78.3%). Moreover, chemical, ADMET, chrysin good ligand.

Язык: Английский

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Natural Compounds and Products from an Anti-Aging Perspective

Molecules, Год журнала: 2022, Номер 27(20), С. 7084 - 7084

Опубликована: Окт. 20, 2022

Aging is a very complex process that accompanied by degenerative impairment in many of the major functions human body over time. This inevitable influenced hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, so on. Many external internal signs symptoms are related with aging senescence, including skin dryness wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, consequence imbalance between pro- antioxidants, one main provoking factors causing aging-related damages concerns, due to generation highly reactive byproducts oxygen nitrogen species during metabolism, which result cellular damage apoptosis. Antioxidants can prevent these processes extend healthy longevity ability inhibit formation free radicals or interrupt their propagation, thereby lowering level oxidative stress. review focuses on supporting antioxidant system organism balancing diet through consumption necessary amount natural ingredients, vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, drinking water.

Язык: Английский

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The Neuroprotective Potentiality of Flavonoids on Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(23), С. 14835 - 14835

Опубликована: Ноя. 27, 2022

Alzheimer's disease (AD), due to its spread, has become a global health priority, and is characterized by senile dementia progressive disability. The main cause of AD other neurodegenerations (Huntington, Parkinson, Amyotrophic Lateral Sclerosis) are aggregated protein accumulation oxidative damage. Recent research on secondary metabolites plants such as polyphenols demonstrated that they may slow the progression AD. flavonoids' mechanism action in involved inhibition acetylcholinesterase, butyrylcholinesterase, Tau aggregation, β-secretase, stress, inflammation, apoptosis through modulation signaling pathways which implicated cognitive neuroprotective functions, ERK, PI3-kinase/Akt, NFKB, MAPKs, endogenous antioxidant enzymatic systems. This review focuses flavonoids their role AD, terms therapeutic potentiality for human health, potential, specific molecular targets.

Язык: Английский

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The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Окт. 10, 2022

Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases risk neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant properties protects cells against OS. We have viewed NCBI database, PubMed, Science Direct (Elsevier), Springer-Nature, ResearchGate, Google Scholar databases to search collect relevant articles during preparation this review. The keywords are OS, diseases, fisetin, etc. High level ROS in brain tissue decreases ATP levels, mitochondrial membrane potential induces lipid peroxidation, chronic inflammation, DNA damage, apoptosis. subsequent results various neuronal polyphenolic compound, commonly present dietary ingredients. diminish oxidative stress, production, neurotoxicity, neuro-inflammation, neurological disorders. Moreover, it maintains redox profiles, functions inhibits NO production. At molecular level, fisetin regulates activity PI3K/Akt, Nrf2, NF-κB, protein kinase C, MAPK pathways prevent inflammatory response, cytotoxicity. protect neural from inflammation apoptotic degeneration. Thus, can be used prevention

Язык: Английский

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Influence of the Mediterranean Diet on Healthy Aging

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4491 - 4491

Опубликована: Фев. 24, 2023

The life expectancy of the global population has increased. Aging is a natural physiological process that poses major challenges in an increasingly long-lived and frail population. Several molecular mechanisms are involved aging. Likewise, gut microbiota, which influenced by environmental factors such as diet, plays crucial role modulation these mechanisms. Mediterranean well components present it, offer some proof this. Achieving healthy aging should be focused on promotion lifestyle habits reduce development pathologies associated with aging, order to increase quality In this review we analyze influence diet pathways microbiota more favorable patterns, its possible anti-aging treatment.

Язык: Английский

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Biological potential and mechanisms of Tea’s bioactive compounds: An Updated review

Journal of Advanced Research, Год журнала: 2023, Номер 65, С. 345 - 363

Опубликована: Дек. 5, 2023

Tea (Camellia sinensis) has a rich history and is widely consumed across many countries, categorized into green tea, white oolong yellow black dark tea based on the level of fermentation. Based review previous literature, commonly recognized bioactive substances in include polyphenols, amino acids, polysaccharides, alkaloids, terpenoids, macro minerals, trace elements, vitamins, which have been known to various potential health benefits, such as anticancer, antioxidant, anti-inflammatory, anti-diabetes, anti-obesity properties, cardiovascular protection, immune regulation, control intestinal microbiota. Most studies only pointed out characteristics tea's bioactivities, so comprehensive summary pharmacological mechanisms bioactivities their use risks are vital. Review The aim this paper summarize mechanisms, providing scientific basis for application outlining future research directions study tea. Key Scientific Concepts This summarizes main biologically active substances, effects, discusses risks. It may help researchers grasp more progress further promote natural substance medical field.

Язык: Английский

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Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(4), С. 1332 - 1355

Опубликована: Янв. 1, 2024

Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs).Numerous studies reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting phosphorylation or ubiquitination of signaling molecules, which further prevents degradation IκB.Additionally, they prevent NF-κB translocation nucleus and pro-inflammatory cytokine production.Polyphenols such as curcumin, resveratrol, pterostilbene had significant inhibitory effects on NF-κB, treating NDs.Recent experimental findings suggest possess wide range pharmacological properties.Notably, much attention has been directed towards their potential therapeutic in NDs Alzheimer's disease (AD), Parkinson's (PD), cerebral ischemia, anxiety, depression, autism, spinal cord injury (SCI).Much preclinical data supporting neurotherapeutic benefits developed.Nevertheless, this study described significance agents, specifically emphasizing impact pathway.This article offers comprehensive analysis involvement NDs, including both clinical perspectives.

Язык: Английский

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