Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Дек. 16, 2022

Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue cell functions significant increases the risks of various aging-related diseases, including neurodegenerative cardiovascular metabolic musculoskeletal immune system diseases. Although development modern medicine has promoted human health greatly extended life expectancy, aging society, variety chronic diseases have gradually become most important causes disability death elderly individuals. Current research on focuses elucidating how endogenous exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss proteostasis, compromise autophagy, mitochondrial cellular senescence, stem exhaustion, altered intercellular communication, deregulated nutrient sensing) participate regulation aging. Furthermore, thorough pathogenesis to identify interventions that promote longevity caloric restriction, microbiota transplantation, nutritional intervention) clinical treatment methods for (depletion senescent cells, therapy, antioxidative anti-inflammatory treatments, hormone replacement therapy) could decrease incidence turn healthy longevity.

Язык: Английский

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Role of Cholinergic Signaling in Alzheimer’s Disease

Molecules, Год журнала: 2022, Номер 27(6), С. 1816 - 1816

Опубликована: Март 10, 2022

Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer’s disease (AD), progressive commonly diagnosed neurodegenerative disease, characterized cognitive decline behavioral disorders. The pathogenesis of AD complex remains unclear, being affected various factors. hypothesis the earliest theory about AD. Cholinergic atrophy are accelerated age-related diseases such as In addition, abnormal central changes can also induce phosphorylation ttau protein, nerve cell inflammation, apoptosis, other pathological phenomena, but exact mechanism action still unclear. Due unclear pathogenesis, effective methods prevent treat unavailable, research explore novel therapeutic drugs active world. This review summaries role signaling correlation between pathway with risk factors provides latest efficient treatment

Язык: Английский

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Influence of the extraction method on the recovery of bioactive phenolic compounds from food industry by-products

Food Chemistry, Год журнала: 2021, Номер 378, С. 131918 - 131918

Опубликована: Дек. 23, 2021

Agro-foodindustries generate colossal amounts of non-edible waste and by-products, easily accessible as raw materials for up-cycling active phytochemicals. Phenolic compounds are particularly relevant in this field given their abundance plant residues the market interest functionalities (e.g. natural antioxidant activity) part nutraceutical, cosmetological biomedical formulations. In "bench-to-bedside" achievements, sample extraction is essential because valorization benefits from matrix desorption solubilization targeted phytocompounds. Specifically, composition polarity extractant, optimal particle size sample:solvent ratio, well pH, pressure temperature strategic release stability mobilized species. On other hand, current green chemistry environmental rules require approaches that eliminate polluting consumables reduce energy needs. Thus, following pages provide an update on advanced technologies sustainable efficient recovery phenolics matrices.

Язык: Английский

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Health Benefits of Quercetin in Age-Related Diseases

Molecules, Год журнала: 2022, Номер 27(8), С. 2498 - 2498

Опубликована: Апрель 13, 2022

Polyphenols are the known group of phytochemicals that essentially consists phenolic rings. These plant product present in varied fruits and vegetables. secondary metabolites perform a protective function plants from environmental biological stress. When consumed as human diet these also to prevent various age-associated diseases. possess antioxidant properties protect against oxidative The literature survey was carried out using databases such PubMed, Science direct Springer. research articles last 10-12 years were selected for this review based on its relevancy with topic. mainly focused quercetin health benefits. highlights main functions flavonoid, quercetin. Quercetin is among widely occurring polyphenol, found abundantly nature. It commonly different products. Onion have highest quantity This compound possessed considered aging. be both free conjugated forms. has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, anti-viral properties. molecule lipophilic can easily cross BBB (Blood-Brain Barrier) hence protects neurodegenerative Various vivo vitro studies demonstrated role here detailed curative agent neurodegeneration, diabetes, cancer, inflammation been out. Studies proved plays crucial prevention age-related disorders. potent which currently being used pharmaceuticals. Properties further explored other Nanoformulations liposomal formulations made treat age associated

Язык: Английский

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Techniques and modeling of polyphenol extraction from food: a review

Environmental Chemistry Letters, Год журнала: 2021, Номер 19(4), С. 3409 - 3443

Опубликована: Март 17, 2021

Язык: Английский

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Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms

Molecules, Год журнала: 2021, Номер 26(4), С. 985 - 985

Опубликована: Фев. 12, 2021

Nutrition transition can be defined as shifts in food habits, and it is characterized by high-fat (chiefly saturated animal fat), hypercaloric salty consumption at the expense of dietary fibers, minerals vitamins. Western patterns serve a model for studying impact nutrition on civilization diseases, such obesity, which commonly associated with oxidative stress inflammation. In fact, reactive oxygen species (ROS) overproduction nuclear factor-κB (NF-κB)-mediated inflammation obesity. NF-κB regulates gene expression several oxidant-responsive adipokines including tumor necrosis factor-α (TNF-α). Moreover, AMP-activated protein kinase (AMPK), plays pivotal role energy homeostasis modulation metabolic inflammation, downregulated IκB (IKK)-dependent TNF-α activation. On other hand, adherence to Mediterranean-style diet highly encouraged because its healthy pattern, includes antioxidant nutraceuticals polyphenols. Indeed, hydroxycinnamic derivatives, quercetin, resveratrol, oleuropein hydroxytyrosol, are well known their anti-inflammatory activities, exert anti-obesity proprieties. this review, we highlight most common polyphenols from Mediterranean foods molecular mechanisms that mediate obesity-related Hence, discuss effects these number signaling pathways. We note (MedDiet) de-regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) NF-κB-mediated stress, MedDiet also effective upregulating downstream effectors proteins, chiefly AMPK.

Язык: Английский

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Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

Molecules, Год журнала: 2019, Номер 25(1), С. 63 - 63

Опубликована: Дек. 23, 2019

Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non-communicable diseases. Although foods contain complex mixtures polyphenols, numerous factors can affect their content. Besides the well-known capability these molecules to act as antioxidants, they are able interact cell-signaling pathways, modulating gene expression, influencing activity transcription factors, and microRNAs. Here we deeply describe four polyphenols used nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), curcumin, summarizing current knowledge about them, spanning from sources epigenetic capabilities compounds on microRNA modulation.

Язык: Английский

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Kefir and Its Biological Activities

Foods, Год журнала: 2021, Номер 10(6), С. 1210 - 1210

Опубликована: Май 27, 2021

Kefir is a fermented beverage with renowned probiotics that coexist in symbiotic association other microorganisms kefir grains. This consumption associated wide array of nutraceutical benefits, including anti-inflammatory, anti-oxidative, anti-cancer, anti-microbial, anti-diabetic, anti-hypertensive, and anti-hypercholesterolemic effects. Moreover, can be adapted into different substrates which allow the production new functional beverages to provide product diversification. Being safe inexpensive, there an immense global interest kefir's nutritional potential. Due their promising kefir-like products have great prospect for commercialization. manuscript reviews therapeutic aspects date, potential applications health food industries, along limitations. The literature reviewed here demonstrates growing demand as owing number health-promoting properties.

Язык: Английский

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Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota

Critical Reviews in Food Science and Nutrition, Год журнала: 2020, Номер 61(13), С. 2175 - 2193

Опубликована: Июнь 4, 2020

Naturally occurring compounds polyphenols are secondary metabolites of plants, comprised several categories, namely, flavonoids, phenolic acids, lignans and stilbenes. The biological aging process is driven by a series interrelated mechanisms, including oxidative stress, inflammation status, autophagy function, through diverse signaling pathways. Moreover, the crucial role gut microbiota in regulating health status was widely demonstrated. In recent years, potential anti-aging benefits have been gaining increasing scientific interest due to their capability modulate damage, inflammation, autophagy, microbiota. This review highlights influence preventing disorders augmenting lifespan based on microbiota, encourages research novel polyphenol-based strategies clinical trials develop nutrition-oriented holistic therapy.

Язык: Английский

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Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer

Frontiers in Immunology, Год журнала: 2020, Номер 11

Опубликована: Фев. 21, 2020

Many patients with cancer suffer from anemia, depression and an impaired quality of life (QoL). These often also show decreased plasma tryptophan levels increased kynurenine concentrations in parallel elevated Th1 type immune activation marker neopterin. In the course anti-tumor response, pro-inflammatory cytokine interferon gamma (IFN-𝛾) induces both, enzyme indoleamine 2,3-dioxygenase (IDO) to degrade GTP-cyclohydrolase I form High neopterin as well ratio (Kyn/Trp) blood are predictive for a worse outcome. Inflammation-mediated catabolism along pathway is related fatigue anemia QoL solid tumors. fact, enhanced breakdown might greatly contribute development patients. IDO stimulation exert regulatory mechanisms, which may impair responses. addition, tumor cells can weaken responses directed against them. expression tissue associated poor prognosis The efficiency IDO-inhibitors inhibit progression currently tested combination established chemotherapies checkpoint inhibitors. its possible influence on persistence discussed.

Язык: Английский

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