Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma DOI Creative Commons
Changtian Ye, Joseph A. Behnke, Katherine R. Hardin

и другие.

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Апрель 3, 2023

Repetitive physical insults to the head, including those that elicit mild traumatic brain injury (mTBI), are a known risk factor for variety of neurodegenerative conditions Alzheimer’s disease (AD), Parkinson’s (PD), and chronic encephalopathy (CTE). Although most individuals who sustain mTBI typically achieve seemingly full recovery within few weeks, subset experience delayed-onset symptoms later in life. As research has focused on acute phase injury, there is an incomplete understanding mechanisms related late-life emergence neurodegeneration after early exposure head trauma. The recent adoption Drosophila -based models provides several unique advantages over existing preclinical animal models, tractable framework amenable high-throughput assays short relative lifespan conducive lifelong mechanistic investigation. use flies also opportunity investigate important factors associated with conditions, specifically age sex. In this review, we survey current literature examines sex as contributing trauma-mediated humans mammalian models. We discuss similarities disparities between human fly aging, differences, pathophysiology. Finally, highlight effective tool investigating underlying trauma-induced identifying therapeutic targets treatment recovery.

Язык: Английский

Evolving Landscape of Parkinson’s Disease Research: Challenges and Perspectives DOI Creative Commons
Rumiana Koynova, Janet M. Sasso, Qiongqiong Angela Zhou

и другие.

ACS Omega, Год журнала: 2025, Номер 10(2), С. 1864 - 1892

Опубликована: Янв. 8, 2025

Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects movement. It occurs due to gradual deficit of dopamine-producing brain cells, particularly in the substantia nigra. The precise etiology PD not fully understood, but it likely involves combination genetic and environmental factors. therapies available at present alleviate symptoms do stop disease's advancement. Research endeavors are currently directed inventing disease-controlling aim inherent mechanisms PD. biomarker breakthroughs hold enormous potential: earlier diagnosis, better monitoring, targeted treatment based on individual response could significantly improve patient outcomes ease burden this disease. research an active evolving field, focusing understanding mechanisms, identifying biomarkers, developing new treatments, improving care. In report, we explore data from CAS Content Collection outline progress We analyze publication landscape offer perspective into latest expertise advancements. Key emerging concepts reviewed strategies fight evaluated. Pharmacological targets, risk factors, as well comorbid diseases explored, clinical usage products against with their production pipelines trials for drug repurposing examined. This review aims comprehensive overview advancing current about PD, define challenges, assess growth prospects stimulate efforts battling

Язык: Английский

Процитировано

1
The central role of the NLRP3 inflammasome pathway in the pathogenesis of age-related diseases in the eye and the brain DOI
Jack Jonathan Maran,

Moradeke M. Adesina,

Colin Green

и другие.

Ageing Research Reviews, Год журнала: 2023, Номер 88, С. 101954 - 101954

Опубликована: Май 15, 2023

Язык: Английский

Процитировано

18
Role of F-actin-mediated endocytosis and exercise in mitochondrial transplantation in an experimental Parkinson's disease mouse model DOI Open Access
Rachit Jain,

Nusrat Begum,

Shruti Rajan

и другие.

Mitochondrion, Год журнала: 2023, Номер 74, С. 101824 - 101824

Опубликована: Ноя. 29, 2023

Язык: Английский

Процитировано

16
A naturally occurring variant of SHLP2 is a protective factor in Parkinson’s disease DOI Creative Commons
Su‐Jeong Kim, Brendan Miller, Nicolas Hartel

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер 29(2), С. 505 - 517

Опубликована: Янв. 3, 2024

Mitochondrial DNA single nucleotide polymorphisms (mtSNPs) have been associated with a reduced risk of developing Parkinson's disease (PD), yet the underlying mechanisms remain elusive. In this study, we investigate functional role PD-associated mtSNP that impacts mitochondrial-derived peptide (MDP) Small Humanin-like Peptide 2 (SHLP2). We identify m.2158 T > C, PD risk, within small open reading frame encoding SHLP2. This results in an alternative form SHLP2 (lysine 4 replaced arginine; K4R). Using targeted mass spectrometry, detect specific tryptic fragments neuronal cells and demonstrate its binding to mitochondrial complex 1. Notably, observe K4R variant, exhibits increased stability compared WT Additionally, both show enhanced protection against dysfunction vitro experiments confer PD-inducing toxin, 1 inhibitor, mouse model. study sheds light on consequences C provides insights into potential by which may reduce PD.

Язык: Английский

Процитировано

6
Advancements in Genetic and Biochemical Insights: Unraveling the Etiopathogenesis of Neurodegeneration in Parkinson’s Disease DOI Creative Commons
Yashumati Ratan, Aishwarya Rajput, Ashutosh Pareek

и другие.

Biomolecules, Год журнала: 2024, Номер 14(1), С. 73 - 73

Опубликована: Янв. 5, 2024

Parkinson’s disease (PD) is the second most prevalent neurodegenerative movement disorder worldwide, which primarily characterized by motor impairments. Even though multiple hypotheses have been proposed over decades that explain pathogenesis of PD, presently, there are no cures or promising preventive therapies for PD. This could be attributed to intricate pathophysiology PD and poorly understood molecular mechanism. To address these challenges comprehensively, a thorough model imperative nuanced understanding PD’s underlying pathogenic mechanisms. review offers detailed analysis current state knowledge regarding mechanisms with particular emphasis on roles played gene-based factors in disease’s development progression. study includes an extensive discussion proteins mutations primary genes linked including α-synuclein, GBA1, LRRK2, VPS35, PINK1, DJ-1, Parkin. Further, this explores plausible DAergic neural loss, non-motor non-dopaminergic pathologies, risk associated The present will encourage related research fields understand better analyze status biochemical might contribute design efficacious safe treatment strategies future endeavors.

Язык: Английский

Процитировано

6
Therapeutic approaches targeting aging and cellular senescence in Huntington's disease DOI Creative Commons
Asif Ahmad Bhat, Ehssan Moglad, Muhammad Afzal

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(10)

Опубликована: Окт. 1, 2024

Huntington's disease (HD) is a devastating neurodegenerative that manifested by gradual loss of physical, cognitive, and mental abilities. As the advances, age has major impact on pathogenic signature mutant huntingtin (mHTT) protein aggregation. This review aims to explore intricate relationship between aging, mHTT toxicity, cellular senescence in HD. Scientific data interplay mHTT, HD were collected from several academic databases, including PubMed, Google Scholar, Google, ScienceDirect. The search terms employed "AGING," "HUNTINGTON'S DISEASE," "MUTANT HUNTINGTIN," "CELLULAR SENESCENCE." Additionally, gather information molecular mechanisms potential therapeutic targets, was extended include relevant such as "DNA DAMAGE," "OXIDATIVE STRESS," "AUTOPHAGY." According research, aging leads worsening pathophysiology through some processes. result accumulation, promoted, which causes DNA damage, oxidative stress, decreased autophagy, increased inflammatory responses. Pro-inflammatory cytokines other substances are released senescent cells, may worsen neuronal damage course disease. It been shown treatments directed at these pathways reduce symptoms enhance longevity experimental animals, pointing new possibility treating condition. Through their amplification harmful effects play crucial roles development Comprehending interplays creates novel opportunities for measures targeted alleviating enhancing patients' quality life.

Язык: Английский

Процитировано

6
Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis DOI

Haneen Y. Khidr,

Noha F. Hassan,

Sahar S. Abdelrahman

и другие.

International Immunopharmacology, Год журнала: 2023, Номер 125, С. 111207 - 111207

Опубликована: Ноя. 11, 2023

Язык: Английский

Процитировано

14
Mitochondrial dysfunction-targeting therapeutics of natural products in Parkinson’s disease DOI Creative Commons

Ting He,

Xiaoyan Lin, Anping Su

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Май 10, 2023

Parkinson’s disease (PD), the second most common neurodegenerative worldwide, often occurs in middle-aged and elderly individuals. The pathogenesis of PD is complex includes mitochondrial dysfunction, oxidative stress. Recently, natural products with multiple structures their bioactive components have become one important resources for small molecule drug research targeting dysfunction. Multiple lines studies proven that display ameliorative benefits treatment by regulating Therefore, a comprehensive search recent published articles between 2012 2022 PubMed, Web Science, Elesvier, Wliey Springer was carried out, focusing on original publications related to against restoring This paper presented mechanisms various kinds PD-related dysfunction regulation provided evidence are promising be developed as drugs therapeutics.

Язык: Английский

Процитировано

13
Reinforcing the Evidence of Mitochondrial Dysfunction in Long COVID Patients Using a Multiplatform Mass Spectrometry-Based Metabolomics Approach DOI
Sara Martínez, Oihane E. Albóniga, María Rosa López‐Huertas

и другие.

Journal of Proteome Research, Год журнала: 2024, Номер 23(8), С. 3025 - 3040

Опубликована: Апрель 3, 2024

Despite the recent and increasing knowledge surrounding COVID-19 infection, underlying mechanisms of persistence symptoms for a long time after acute infection are still not completely understood. Here, multiplatform mass spectrometry-based approach was used metabolomic lipidomic profiling human plasma samples from Long COVID patients (n = 40) to reveal mitochondrial dysfunction when compared with individuals fully recovered mild 40). Untargeted analysis using CE-ESI(+/−)-TOF-MS GC-Q-MS performed. Additionally, LC-ESI(+/−)-QTOF-MS based on an in-house library revealed 447 lipid species identified high confidence annotation level. The integration complementary analytical platforms has allowed comprehensive metabolic characterization alterations in disease that found 46 relevant metabolites which discriminate between patients. We report specific altered COVID, mainly related decrease amino acid metabolism ceramide levels increase tricarboxylic (TCA) cycle, reinforcing evidence impaired function. most shown this study will help better understand insights syndrome by providing deeper basis pathology.

Язык: Английский

Процитировано

5
Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice DOI Creative Commons
Yuvarani Masarapu, Egle Cekanaviciute, Žaneta Andrusivová

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 11, 2024

Abstract Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate impact spaceflight on mouse brain in female mice. Our comparative analysis between ground control spaceflight-exposed animals revealed alterations essential processes including neurogenesis, synaptogenesis synaptic transmission, particularly affecting cortex, hippocampus, striatum neuroendocrine structures. Additionally, observed astrocyte activation signs immune dysfunction. At pathway level, some spaceflight-induced changes exhibit similarities neurodegenerative disorders, marked oxidative stress protein misfolding. integrated serves as stepping stone towards understanding CNS impairments at level individual regions cell types, provides basis comparison future studies. For broader scientific impact, all datasets from study are available through interactive data portal, well National Aeronautics Space Administration (NASA) Open Science Data Repository (OSDR).

Язык: Английский

Процитировано

5