Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Regular
exercise
enhances
life
quality,
lowers
the
risk
of
cognitive
damage,
and
slows
advancement
Alzheimer's
disease
(AD).
Natural
compounds
rich
in
polyphenols
have
garnered
attention
as
a
non-pharmacological
means
treating
preventing
AD.
The
primary
component
wine,
grape
seeds,
nuts
is
polyphenols.
Research
suggests
that
slow
down
rate
neurodegeneration
AD
lessen
learning
impairment.
Furthermore,
brain
impairments
related
to
cognition.
Additionally,
can
specifically
restructure
amyloid-β
(Aβ)
structures
soluble
oligomers
into
non-toxic
alternative
species.
They
also
been
revealed
increase
brain-derived
neurotrophic
factors
expression,
suggesting
they
positive
impact
on
creation
neurotrophins.
benefits
polyphenol
supplementation
exercise,
which
both
provide
neuroprotection,
not
well
studied
patients.
This
review
aimed
investigate
effects
combined
inflammation,
several
conformational
toxic
species
Aβ,
Aβ-induced
apoptosis
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 395 - 395
Опубликована: Март 26, 2024
Central
neurological
disorders
are
significant
contributors
to
morbidity,
mortality,
and
long-term
disability
globally
in
modern
society.
These
encompass
neurodegenerative
diseases,
ischemic
brain
traumatic
injury,
epilepsy,
depression,
more.
The
involved
pathogenesis
is
notably
intricate
diverse.
Ferroptosis
neuroinflammation
play
pivotal
roles
elucidating
the
causes
of
cognitive
impairment
stemming
from
these
diseases.
Given
concurrent
occurrence
ferroptosis
due
metabolic
shifts
such
as
iron
ROS,
well
their
critical
central
nervous
disorders,
investigation
into
co-regulatory
mechanism
has
emerged
a
prominent
area
research.
This
paper
delves
mechanisms
along
with
interrelationship.
It
specifically
emphasizes
core
molecules
within
shared
pathways
governing
neuroinflammation,
including
SIRT1,
Nrf2,
NF-κB,
Cox-2,
iNOS/NO·,
how
different
immune
cells
structures
contribute
dysfunction
through
mechanisms.
Researchers’
findings
suggest
that
mutually
promote
each
other
may
represent
key
factors
progression
disorders.
A
deeper
comprehension
common
pathway
between
cellular
holds
promise
for
improving
symptoms
prognosis
related
GeroScience,
Год журнала:
2024,
Номер
46(6), С. 6473 - 6510
Опубликована: Июль 4, 2024
Abstract
This
review
provides
a
comprehensive
synthesis
of
longitudinal
observational
and
interventional
studies
on
the
cardiometabolic
effects
coffee
consumption.
It
explores
biological
mechanisms,
clinical
policy
implications,
highlights
gaps
in
evidence
while
suggesting
future
research
directions.
also
reviews
causal
relationships
between
consumption
outcomes
from
Mendelian
randomization
(MR)
studies.
Findings
indicate
that
may
cause
short-term
increases
blood
pressure,
it
does
not
contribute
to
long-term
hypertension
risk.
There
is
limited
indicating
intake
might
reduce
risk
metabolic
syndrome
non-alcoholic
fatty
liver
disease.
Furthermore,
consistently
linked
with
reduced
risks
type
2
diabetes
(T2D)
chronic
kidney
disease
(CKD),
showing
dose-response
relationships.
The
relationship
cardiovascular
complex,
potential
stroke
prevention
benefits
but
ambiguous
coronary
heart
Moderate
consumption,
typically
ranging
1
5
cups
per
day,
failure,
its
impact
atrial
fibrillation
remains
inconclusive.
associated
lower
all-cause
mortality,
following
U-shaped
pattern,
largest
reduction
observed
at
moderate
levels.
Except
for
T2D
CKD,
MR
do
robustly
support
link
adverse
outcomes.
beneficial
health
are
consistent
across
age,
sex,
geographical
regions,
subtypes
multi-dimensional,
involving
antioxidative,
anti-inflammatory,
lipid-modulating,
insulin-sensitizing,
thermogenic
effects.
Based
fundamental
processes
involved
aging,
has
extending
healthspan
increasing
longevity.
findings
underscore
need
understand
underlying
mechanisms
refine
recommendations
regarding
Frontiers in Cellular Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Июль 3, 2024
General
anesthesia,
as
a
commonly
used
medical
intervention,
has
been
widely
applied
during
surgical
procedures
to
ensure
rapid
loss
of
consciousness
and
pain
relief
for
patients.
However,
recent
research
suggests
that
general
anesthesia
may
be
associated
with
the
occurrence
perioperative
neurocognitive
disorder
(PND).
PND
is
characterized
by
decline
in
cognitive
function
after
surgery,
including
impairments
attention,
memory,
learning,
executive
functions.
With
increasing
trend
population
aging,
burden
on
patients
society's
health
economy
becoming
more
evident.
Currently,
clinical
consensus
tends
believe
peripheral
inflammation
involved
pathogenesis
PND,
providing
strong
support
further
investigating
mechanisms
prevention
PND.
Brain Research Bulletin,
Год журнала:
2025,
Номер
unknown, С. 111253 - 111253
Опубликована: Фев. 1, 2025
Neurodegenerative
diseases
(NDDs)
are
a
class
of
cognitive
and
motor
disorders
including
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
Amyotrophic
Lateral
Sclerosis
(ALS),
others.
They
caused
by
lesions
in
cells
tissues
the
central
nervous
system,
resulting
corresponding
dysfunctions
consequent
decline
functions.
Neural
extremely
vulnerable
to
oxidative
stress,
which
plays
critical
biological
roles
NDDs.
Aromatic
compounds
found
extensively
natural
plants
have
substantial
effects
anti-oxidative
stress
damage,
not
only
wide
range
research
applications
cosmetics,
foods,
etc.,
but
also
frequently
utilized
treatment
various
system
diseases.
This
review
summarizes
relevant
mechanisms
NDDs
(AD,
PD,
HD,
ALS)
reviews
aromatic
such
as
polyphenols,
terpenoids,
flavonoids
that
can
be
used
management
neurodegenerative
diseases,
well
their
specific
antioxidant
action.
will
serve
reference
for
future
experimental
studies
on
illnesses
while
offering
fresh
insights
into
clinical
therapy.
