Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102211 - 102211

Опубликована: Фев. 1, 2024

Язык: Английский

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Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1062 - 1062

Опубликована: Авг. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Язык: Английский

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The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Язык: Английский

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Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102450 - 102450

Опубликована: Авг. 10, 2024

Язык: Английский

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Infection, Neuroinflammation and Interventions for Healthy Brain and Longevity

Healthy ageing and longevity, Год журнала: 2024, Номер unknown, С. 255 - 275

Опубликована: Янв. 1, 2024

Язык: Английский

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Physical exercise and lifestyle management: Preventive measures for Alzheimer's disease

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 169 - 182

Опубликована: Окт. 25, 2024

Язык: Английский

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Molecular and neuroimaging biomarkers in the diagnosis of Alzheimer's disease

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 51 - 65

Опубликована: Окт. 25, 2024

Язык: Английский

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