Circulating inflammatory proteins and risk of Parkinson’s disease and other neurodegenerative disorders: a two-sample Mendelian randomization study DOI Creative Commons
Zhichun Chen, Guanglu Li, Liche Zhou

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 6, 2024

Abstract Background: Accumulating studies have suggested associations between peripheral inflammation and neurodegenerative disorders, including Parkinson’s disease (PD). Objective: To evaluate the causal 91 plasma inflammatory proteins 4 disorders. Methods: Two-sample Mendelian randomization were performed using summary statistics extracted from genome-wide association of Results: Genetically proxied tumor necrosis factor receptor superfamily member 9 levels causally associated with reduced risk PD (odds ratio [OR] = 0.82, 95% confidence interval [CI] 0.74-0.92, p 4.18 x 10-4, Bonferroni-corrected < 0.05 for proteins). Additionally, we identified potential C-C motif chemokine 20 (OR 1.14, 95%CI 1.03-1.25, 1.29 10-2) Alzheimer’s disease, leukemia inhibitory 0.91, 0.84-0.98, 1.12 factor-β 0.95, 0.93-0.98, 1.01 10-3) amyotrophic lateral sclerosis, adenosine deaminase 0.81, 0.71-0.94, 5.14 interleukin-18 0.69-0.96, 1.68 multiple sclerosis. Conclusions: Our study unveils plausible circulating factors These findings hold promise promoting assessment prevention meriting further exploration.

Язык: Английский

Mendelian Randomization Study Reveals Causal Pathways for Hypertrophic Cardiomyopathy, Cardiovascular Proteins, and Atrial Fibrillation DOI
Yifei Zhang,

C Y Guo,

Lanxin Wang

и другие.

British Journal of Hospital Medicine, Год журнала: 2025, Номер unknown, С. 1 - 19

Опубликована: Янв. 14, 2025

Aims/Background Research evidence has demonstrated a significant association between hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF), but the causality pattern of this link remain unexplored. Therefore, study investigated causal relationship HCM AF using two-sample bidirectional Mendelian randomization (MR) approach. Additionally, assessed role cardiovascular proteins (CPs) associated with diseases by applying two-step MR analysis. Methods Data for HCM, AF, 90 CPs were obtained from Finn Gen IEU Open GWAS Project databases. MR-Egger, inverse variance weighting (IVW), weighted median estimator (WME), mode, simple mode used to estimate inferences. Furthermore, Cochran's Q test, MR-Egger's intercept terms, Leave-one-out methods determined heterogeneity, horizontal pleiotropy, sensitivity. mediation effects assess in AF. Results Two-sample analysis revealed as risk factor (odds ratio (OR) = 1.008, 95% confidence interval (CI): 1.001-1.016, p 0.029) was found increase developing (OR 1.145, CI: 0.963-1.361, 0.126). Moreover, Two-step analyses indicated that 5 causally HCM; 12 1 CP (Melusin) both Melusin observed protective may serve mediator variable these two conditions (mediation effect 0.0004, 5.5178%, 5.4624-5.5731). Conclusion serving risk.

Язык: Английский

Процитировано

0
Proximity extension assay reveals serum inflammatory biomarkers in two amyotrophic lateral sclerosis cohorts DOI Creative Commons
Yujing Chen, Shujuan Sun, Ni Gao

и другие.

Neurobiology of Disease, Год журнала: 2025, Номер unknown, С. 106933 - 106933

Опубликована: Апрель 1, 2025

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with both clinical and hereditary heterogeneity. Inflammation has been suggested to play an important role in ALS pathophysiology. In this study, we aimed identify serum inflammatory alterations develop effective biomarkers assist the diagnosis of ALS. Through proximity extension assay (PEA), investigated two cohorts compared healthy controls (HCs), including sporadic patients genetic patients. We found that CHIT1, OSM, SIRT2, CDCP1 5 other factors were significantly increased 6 different between HCs. Using XGBoost binary logistic regression analysis, developed two-serum protein diagnostic panel (CHIT1 CDCP1), area under curve (AUC) was 0.904 original cohort 0.907 replication cohort. Based on Mendelian Randomization (MR), OSM SIRT2 are associated risk conclusion, our study revealed consistent replicable profile biomarker can differentiate from HCs cohorts, which may advancing current understanding process identifying novel therapeutic strategies for

Язык: Английский

Процитировано

0
Association between circulating inflammatory proteins and gout: A Mendelian randomization study DOI Creative Commons

Xiaoqiang Xie,

Yanjie Song,

Wenwen Chen

и другие.

Medicine, Год журнала: 2025, Номер 104(20), С. e42379 - e42379

Опубликована: Май 16, 2025

Clinical studies have consistently demonstrated that inflammation is a critical factor in the pathophysiology and progression of gout. This study aims to explore causal relationship between CIPs gout, utilizing MR conjunction with meta-analyses. We utilized genetic data pertaining gout from GWAS which involved 3576 cases 147,221 control participants. A total 132 were extracted identify SNPs associated The primary analytical approach was IVW method. Sensitivity analyses indicated no pleiotropy or heterogeneity. results revealed several European populations. analysis indicate FGF-21, MMP-1, G-CSF, IFN-γ are pathogenesis may influence expression CXCL1, IL-1Ra, TNF-α. Consequently, targeted research focusing on specific could provide promising strategy for treatment prevention offering potential therapeutic targets underlying inflammatory mechanisms disease.

Язык: Английский

Процитировано

0
Elevated peripheral inflammation is associated with choroid plexus enlargement in independent sporadic amyotrophic lateral sclerosis cohorts DOI Creative Commons
Shujuan Sun, Yujing Chen, Yan Yun

и другие.

Fluids and Barriers of the CNS, Год журнала: 2024, Номер 21(1)

Опубликована: Окт. 21, 2024

Язык: Английский

Процитировано

2
Circulating inflammatory proteins and risk of Parkinson’s disease and other neurodegenerative disorders: a two-sample Mendelian randomization study DOI Open Access
Zhichun Chen, Guanglu Li, Liche Zhou

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 5, 2024

Abstract Background Accumulating studies have suggested associations between peripheral inflammation and neurodegenerative disorders, including Parkinson’s disease (PD). Objective To evaluate the causal 91 plasma inflammatory proteins 4 disorders. Methods Two-sample Mendelian randomization were performed using summary statistics extracted from genome-wide association of Results Genetically proxied tumor necrosis factor receptor superfamily member 9 levels causally associated with reduced risk PD (odds ratio [OR] = 0.82, 95% confidence interval [CI] 0.74-0.92, p 4.18 x 10 −4 , Bonferroni-corrected < 0.05 for proteins). Additionally, we identified potential C-C motif chemokine 20 (OR 1.14, 95%CI 1.03-1.25, 1.29 −2 ) Alzheimer’s disease, leukemia inhibitory 0.91, 0.84-0.98, 1.12 factor-β 0.95, 0.93-0.98, 1.01 −3 amyotrophic lateral sclerosis, adenosine deaminase 0.81, 0.71-0.94, 5.14 interleukin-18 0.69-0.96, 1.68 multiple sclerosis. Conclusions Our study unveils plausible circulating factors These findings hold promise promoting assessment prevention meriting further exploration.

Язык: Английский

Процитировано

0
Circulating inflammatory proteins and risk of Parkinson’s disease and other neurodegenerative disorders: a two-sample Mendelian randomization study DOI Creative Commons
Zhichun Chen, Guanglu Li, Liche Zhou

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 6, 2024

Abstract Background: Accumulating studies have suggested associations between peripheral inflammation and neurodegenerative disorders, including Parkinson’s disease (PD). Objective: To evaluate the causal 91 plasma inflammatory proteins 4 disorders. Methods: Two-sample Mendelian randomization were performed using summary statistics extracted from genome-wide association of Results: Genetically proxied tumor necrosis factor receptor superfamily member 9 levels causally associated with reduced risk PD (odds ratio [OR] = 0.82, 95% confidence interval [CI] 0.74-0.92, p 4.18 x 10-4, Bonferroni-corrected < 0.05 for proteins). Additionally, we identified potential C-C motif chemokine 20 (OR 1.14, 95%CI 1.03-1.25, 1.29 10-2) Alzheimer’s disease, leukemia inhibitory 0.91, 0.84-0.98, 1.12 factor-β 0.95, 0.93-0.98, 1.01 10-3) amyotrophic lateral sclerosis, adenosine deaminase 0.81, 0.71-0.94, 5.14 interleukin-18 0.69-0.96, 1.68 multiple sclerosis. Conclusions: Our study unveils plausible circulating factors These findings hold promise promoting assessment prevention meriting further exploration.

Язык: Английский

Процитировано

0