Circulating inflammatory proteins and risk of Parkinson’s disease and other neurodegenerative disorders: a two-sample Mendelian randomization study DOI Creative Commons
Zhichun Chen, Guanglu Li, Liche Zhou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 6, 2024

Abstract Background: Accumulating studies have suggested associations between peripheral inflammation and neurodegenerative disorders, including Parkinson’s disease (PD). Objective: To evaluate the causal 91 plasma inflammatory proteins 4 disorders. Methods: Two-sample Mendelian randomization were performed using summary statistics extracted from genome-wide association of Results: Genetically proxied tumor necrosis factor receptor superfamily member 9 levels causally associated with reduced risk PD (odds ratio [OR] = 0.82, 95% confidence interval [CI] 0.74-0.92, p 4.18 x 10-4, Bonferroni-corrected < 0.05 for proteins). Additionally, we identified potential C-C motif chemokine 20 (OR 1.14, 95%CI 1.03-1.25, 1.29 10-2) Alzheimer’s disease, leukemia inhibitory 0.91, 0.84-0.98, 1.12 factor-β 0.95, 0.93-0.98, 1.01 10-3) amyotrophic lateral sclerosis, adenosine deaminase 0.81, 0.71-0.94, 5.14 interleukin-18 0.69-0.96, 1.68 multiple sclerosis. Conclusions: Our study unveils plausible circulating factors These findings hold promise promoting assessment prevention meriting further exploration.

Language: Английский

Mendelian Randomization Study Reveals Causal Pathways for Hypertrophic Cardiomyopathy, Cardiovascular Proteins, and Atrial Fibrillation DOI
Yifei Zhang,

C Y Guo,

Lanxin Wang

et al.

British Journal of Hospital Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Jan. 14, 2025

Aims/Background Research evidence has demonstrated a significant association between hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF), but the causality pattern of this link remain unexplored. Therefore, study investigated causal relationship HCM AF using two-sample bidirectional Mendelian randomization (MR) approach. Additionally, assessed role cardiovascular proteins (CPs) associated with diseases by applying two-step MR analysis. Methods Data for HCM, AF, 90 CPs were obtained from Finn Gen IEU Open GWAS Project databases. MR-Egger, inverse variance weighting (IVW), weighted median estimator (WME), mode, simple mode used to estimate inferences. Furthermore, Cochran's Q test, MR-Egger's intercept terms, Leave-one-out methods determined heterogeneity, horizontal pleiotropy, sensitivity. mediation effects assess in AF. Results Two-sample analysis revealed as risk factor (odds ratio (OR) = 1.008, 95% confidence interval (CI): 1.001-1.016, p 0.029) was found increase developing (OR 1.145, CI: 0.963-1.361, 0.126). Moreover, Two-step analyses indicated that 5 causally HCM; 12 1 CP (Melusin) both Melusin observed protective may serve mediator variable these two conditions (mediation effect 0.0004, 5.5178%, 5.4624-5.5731). Conclusion serving risk.

Language: Английский

Citations

0
Proximity extension assay reveals serum inflammatory biomarkers in two amyotrophic lateral sclerosis cohorts DOI Creative Commons
Yujing Chen, Shujuan Sun, Ni Gao

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106933 - 106933

Published: April 1, 2025

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with both clinical and hereditary heterogeneity. Inflammation has been suggested to play an important role in ALS pathophysiology. In this study, we aimed identify serum inflammatory alterations develop effective biomarkers assist the diagnosis of ALS. Through proximity extension assay (PEA), investigated two cohorts compared healthy controls (HCs), including sporadic patients genetic patients. We found that CHIT1, OSM, SIRT2, CDCP1 5 other factors were significantly increased 6 different between HCs. Using XGBoost binary logistic regression analysis, developed two-serum protein diagnostic panel (CHIT1 CDCP1), area under curve (AUC) was 0.904 original cohort 0.907 replication cohort. Based on Mendelian Randomization (MR), OSM SIRT2 are associated risk conclusion, our study revealed consistent replicable profile biomarker can differentiate from HCs cohorts, which may advancing current understanding process identifying novel therapeutic strategies for

Language: Английский

Citations

0
Elevated peripheral inflammation is associated with choroid plexus enlargement in independent sporadic amyotrophic lateral sclerosis cohorts DOI Creative Commons
Shujuan Sun, Yujing Chen, Yan Yun

et al.

Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)

Published: Oct. 21, 2024

Language: Английский

Citations

2
Circulating inflammatory proteins and risk of Parkinson’s disease and other neurodegenerative disorders: a two-sample Mendelian randomization study DOI Open Access
Zhichun Chen, Guanglu Li, Liche Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 5, 2024

Abstract Background Accumulating studies have suggested associations between peripheral inflammation and neurodegenerative disorders, including Parkinson’s disease (PD). Objective To evaluate the causal 91 plasma inflammatory proteins 4 disorders. Methods Two-sample Mendelian randomization were performed using summary statistics extracted from genome-wide association of Results Genetically proxied tumor necrosis factor receptor superfamily member 9 levels causally associated with reduced risk PD (odds ratio [OR] = 0.82, 95% confidence interval [CI] 0.74-0.92, p 4.18 x 10 −4 , Bonferroni-corrected < 0.05 for proteins). Additionally, we identified potential C-C motif chemokine 20 (OR 1.14, 95%CI 1.03-1.25, 1.29 −2 ) Alzheimer’s disease, leukemia inhibitory 0.91, 0.84-0.98, 1.12 factor-β 0.95, 0.93-0.98, 1.01 −3 amyotrophic lateral sclerosis, adenosine deaminase 0.81, 0.71-0.94, 5.14 interleukin-18 0.69-0.96, 1.68 multiple sclerosis. Conclusions Our study unveils plausible circulating factors These findings hold promise promoting assessment prevention meriting further exploration.

Language: Английский

Citations

0
Circulating inflammatory proteins and risk of Parkinson’s disease and other neurodegenerative disorders: a two-sample Mendelian randomization study DOI Creative Commons
Zhichun Chen, Guanglu Li, Liche Zhou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 6, 2024

Abstract Background: Accumulating studies have suggested associations between peripheral inflammation and neurodegenerative disorders, including Parkinson’s disease (PD). Objective: To evaluate the causal 91 plasma inflammatory proteins 4 disorders. Methods: Two-sample Mendelian randomization were performed using summary statistics extracted from genome-wide association of Results: Genetically proxied tumor necrosis factor receptor superfamily member 9 levels causally associated with reduced risk PD (odds ratio [OR] = 0.82, 95% confidence interval [CI] 0.74-0.92, p 4.18 x 10-4, Bonferroni-corrected < 0.05 for proteins). Additionally, we identified potential C-C motif chemokine 20 (OR 1.14, 95%CI 1.03-1.25, 1.29 10-2) Alzheimer’s disease, leukemia inhibitory 0.91, 0.84-0.98, 1.12 factor-β 0.95, 0.93-0.98, 1.01 10-3) amyotrophic lateral sclerosis, adenosine deaminase 0.81, 0.71-0.94, 5.14 interleukin-18 0.69-0.96, 1.68 multiple sclerosis. Conclusions: Our study unveils plausible circulating factors These findings hold promise promoting assessment prevention meriting further exploration.

Language: Английский

Citations

0