Competitive social feedback amplifies the role of early life contingency in male mice

Science, Год журнала: 2025, Номер 387(6729), С. 81 - 85

Опубликована: Янв. 2, 2025

Contingency (or “luck”) in early life plays an important role shaping individuals’ development. By comparing the developmental trajectories of functionally genetically identical free-living mice who either experienced high levels resource competition (males) or did not (females), we show that magnifies contingency. Male results a feedback loop importance contingency and pushes individuals onto divergent, self-reinforcing trajectories, while same process appears absent females. Our indicate strength sexual selection may be self-limiting, they highlight potential for to lead differences outcomes, even absence any underlying ability (“merit”).

Язык: Английский

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Driver lines for studying associative learning in Drosophila

eLife, Год журнала: 2025, Номер 13

Опубликована: Янв. 29, 2025

The mushroom body (MB) is the center for associative learning in insects. In Drosophila , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult .

Язык: Английский

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Play-like behavior exhibited by the vinegar fly Drosophila melanogaster

Current Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Division of labour in colony defence in a clonal ant

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 380(1922)

Опубликована: Март 20, 2025

Division of labour (DOL) plays a key role across all scales biological organization, but how its expression varies contexts is still poorly understood. Here, we measure DOL in crucial task, colony defence, social insect that affords precise experimental control over individual and traits, the clonal raider ant ( Ooceraea biroi ). We find defence behaviour emerges within colonies near-identical workers, likely reflecting variation response thresholds, it increases with size. Additionally, pupae show higher levels than those without brood. However, do not evidence for behavioural syndrome linking exploration activity, as previously reported other systems. By showing composition size affect group to potential threats, our findings highlight context shaping DOL. This article part theme issue ‘Division driver evolution’.

Язык: Английский

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SAMPL is a high-throughput solution to study unconstrained vertical behavior in small animals

Cell Reports, Год журнала: 2023, Номер 42(6), С. 112573 - 112573

Опубликована: Июнь 1, 2023

Balance and movement are impaired in many neurological disorders. Recent advances behavioral monitoring provide unprecedented access to posture locomotor kinematics but without the throughput scalability necessary screen candidate genes/potential therapeutics. Here, we present a scalable apparatus measure locomotion (SAMPL). SAMPL includes extensible hardware open-source software with real-time processing can acquire data from D. melanogaster, C. elegans, rerio as they move vertically. Using SAMPL, define how zebrafish balance navigate vertically discover small systematic variations among kinematic parameters between genetic backgrounds. We demonstrate SAMPL's ability resolve differences navigation function of effect size gathered, providing key for screens. is therefore both tool model disorders an exemplar scale support

Язык: Английский

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Driver lines for studying associative learning in Drosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 16, 2023

The mushroom body (MB) is the center for associative learning in insects. In Drosophila, intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult Drosophila.

Язык: Английский

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Correlated behavioural plasticities: insights from plasticity evolution, the integrated phenotype and behavioural syndromes

Animal Behaviour, Год журнала: 2023, Номер 200, С. 263 - 271

Опубликована: Май 2, 2023

Integrated phenotypes, that is, correlated suites of traits, can impact both evolutionary and ecological processes. Similarly, phenotypic plasticity, or the ability one genotype to generate multiple act as a facilitator constraint on While there has been an increasing focus behavioural means (i.e. syndromes), less attention paid how plasticity in different traits may be correlated. Such plasticities are likely affect evolution ecology, although possibly ways. Here, we review key insights from three research fields, syndromes, integrated phenotypes provide conceptual framework understand why, when become In particular, conditions under which syndromes predicted important also where have strongest impacts. this review, define plasticities, summarize give rise them highlight testable predictions effort spark targeted into phenomenon. We worked example studying yield new insights.

Язык: Английский

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Driver lines for studying associative learning in Drosophila

Опубликована: Фев. 8, 2024

The mushroom body (MB) is the center for associative learning in insects. In Drosophila, intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult Drosophila.

Язык: Английский

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Shedding Light on Inter-Individual Variability of Olfactory Circuits in Drosophila

Frontiers in Behavioral Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Апрель 25, 2022

Inter-individual differences in behavioral responses, anatomy or functional properties of neuronal populations animals having the same genotype were for a long time disregarded. The majority studies conducted at group level, and usually mean behavior all individuals was considered. Similarly, neurophysiological studies, data pooled normalized from several individuals. This approach is mostly suited to map characterize stereotyped between individuals, but lacks ability depict inter-individual variability regarding wiring physiological characteristics. Recent have shown that biases preferences olfactory stimuli can vary significantly among genotype. origin benefit these diverse “personalities” still unclear needs be further investigated. A perspective taken into account needed explore cellular mechanisms underlying this phenomenon. review focuses on olfaction vinegar fly Drosophila melanogaster summarizes previous recent odor-guided circuits light variability. We address morphological variabilities present each layer circuitry attempt link them individual behavior. Additionally, we discuss factors might influence individuality with regard perception.

Язык: Английский

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Driver lines for studying associative learning in Drosophila

Опубликована: Янв. 6, 2025

The mushroom body (MB) is the center for associative learning in insects. In Drosophila , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult .

Язык: Английский

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