Competitive social feedback amplifies the role of early life contingency in male mice

Science, Journal Year: 2025, Volume and Issue: 387(6729), P. 81 - 85

Published: Jan. 2, 2025

Contingency (or “luck”) in early life plays an important role shaping individuals’ development. By comparing the developmental trajectories of functionally genetically identical free-living mice who either experienced high levels resource competition (males) or did not (females), we show that magnifies contingency. Male results a feedback loop importance contingency and pushes individuals onto divergent, self-reinforcing trajectories, while same process appears absent females. Our indicate strength sexual selection may be self-limiting, they highlight potential for to lead differences outcomes, even absence any underlying ability (“merit”).

Language: Английский

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Driver lines for studying associative learning in Drosophila

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 29, 2025

The mushroom body (MB) is the center for associative learning in insects. In Drosophila , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult .

Language: Английский

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Division of labour in colony defence in a clonal ant

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1922)

Published: March 20, 2025

Division of labour (DOL) plays a key role across all scales biological organization, but how its expression varies contexts is still poorly understood. Here, we measure DOL in crucial task, colony defence, social insect that affords precise experimental control over individual and traits, the clonal raider ant ( Ooceraea biroi ). We find defence behaviour emerges within colonies near-identical workers, likely reflecting variation response thresholds, it increases with size. Additionally, pupae show higher levels than those without brood. However, do not evidence for behavioural syndrome linking exploration activity, as previously reported other systems. By showing composition size affect group to potential threats, our findings highlight context shaping DOL. This article part theme issue ‘Division driver evolution’.

Language: Английский

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SAMPL is a high-throughput solution to study unconstrained vertical behavior in small animals

Cell Reports, Journal Year: 2023, Volume and Issue: 42(6), P. 112573 - 112573

Published: June 1, 2023

Balance and movement are impaired in many neurological disorders. Recent advances behavioral monitoring provide unprecedented access to posture locomotor kinematics but without the throughput scalability necessary screen candidate genes/potential therapeutics. Here, we present a scalable apparatus measure locomotion (SAMPL). SAMPL includes extensible hardware open-source software with real-time processing can acquire data from D. melanogaster, C. elegans, rerio as they move vertically. Using SAMPL, define how zebrafish balance navigate vertically discover small systematic variations among kinematic parameters between genetic backgrounds. We demonstrate SAMPL's ability resolve differences navigation function of effect size gathered, providing key for screens. is therefore both tool model disorders an exemplar scale support

Language: Английский

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Driver lines for studying associative learning in Drosophila

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 16, 2023

The mushroom body (MB) is the center for associative learning in insects. In Drosophila, intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult Drosophila.

Language: Английский

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Correlated behavioural plasticities: insights from plasticity evolution, the integrated phenotype and behavioural syndromes

Animal Behaviour, Journal Year: 2023, Volume and Issue: 200, P. 263 - 271

Published: May 2, 2023

Integrated phenotypes, that is, correlated suites of traits, can impact both evolutionary and ecological processes. Similarly, phenotypic plasticity, or the ability one genotype to generate multiple act as a facilitator constraint on While there has been an increasing focus behavioural means (i.e. syndromes), less attention paid how plasticity in different traits may be correlated. Such plasticities are likely affect evolution ecology, although possibly ways. Here, we review key insights from three research fields, syndromes, integrated phenotypes provide conceptual framework understand why, when become In particular, conditions under which syndromes predicted important also where have strongest impacts. this review, define plasticities, summarize give rise them highlight testable predictions effort spark targeted into phenomenon. We worked example studying yield new insights.

Language: Английский

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Driver lines for studying associative learning in Drosophila

Published: Feb. 8, 2024

The mushroom body (MB) is the center for associative learning in insects. In Drosophila, intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult Drosophila.

Language: Английский

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A neural correlate of individual odor preference in Drosophila

Published: Jan. 21, 2025

Behavior varies even among genetically identical animals raised in the same environment. However, little is known about circuit or anatomical origins of this individuality. Here, we demonstrate a neural correlate Drosophila odor preference behavior olfactory sensory periphery. Namely, idiosyncratic calcium responses projection neuron (PN) dendrites and densities presynaptic protein Bruchpilot receptor (ORN) axon terminals with individual preferences choice between two aversive odorants. The ORN-PN synapse appears to be locus individuality where microscale variation gives rise behavior. Simulating stochasticity synapses 3,062 model antennal lobe recapitulates patterns PN matching experiments. Conversely, other compartments does not recapitulate those patterns. Our results how physiological structural variations can give behavior, when genetics environment are held constant.

Language: Английский

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Play-like behavior exhibited by the vinegar fly Drosophila melanogaster

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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A neural correlate of individual odor preference in Drosophila

eLife, Journal Year: 2025, Volume and Issue: 12

Published: March 11, 2025

Behavior varies even among genetically identical animals raised in the same environment. However, little is known about circuit or anatomical origins of this individuality. Here, we demonstrate a neural correlate Drosophila odor preference behavior olfactory sensory periphery. Namely, idiosyncratic calcium responses projection neuron (PN) dendrites and densities presynaptic protein Bruchpilot receptor (ORN) axon terminals with individual preferences choice between two aversive odorants. The ORN-PN synapse appears to be locus individuality where microscale variation gives rise behavior. Simulating stochasticity synapses 3062 model antennal lobe recapitulates patterns PN matching experiments. Conversely, other compartments does not recapitulate those patterns. Our results how physiological structural variations can give behavior, when genetics environment are held constant.

Language: Английский

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