Behavioral individuality is a consequence of experience, genetics and learning DOI Creative Commons

Riddha Manna,

Johanni Brea,

Gonçalo Vasconcelos Braga

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

ABSTRACT Genetic determinism of behavior supposes that behaviors are fundamentally defined by genetics 1–3 . However, also modified development 4 , environment 5, 6 and learning 7–9 It is assumed if we could control all these factors, would be genetically predictable. These however, cannot controlled in humans, have been impervious to dissection joint even animal models 10–17 How genotype 13 life experience 16 interact shape individual through 17 has lacking experimental evidence, thus remains only hypothesized 8 Here, design an platform which allowed for multi-generational over genetics, development, experience. We measure learning-dependent individuality its sources across thousands diverse Drosophila show plays essential role shaping the distributions behaviors. Further, find genotype-specific bias shapes experience, concert with learning, causes dynamic evolution diversification behavior, a uniform environment. experimentally derive past this order, momentary expression behavior. Finally, while association studies frequently report opposite, severely diminishes predictive power

Язык: Английский

A neural correlate of individual odor preference in Drosophila DOI Open Access
Matthew A. Churgin, Danylo Lavrentovich, M. A. Smith

и другие.

Опубликована: Янв. 21, 2025

Behavior varies even among genetically identical animals raised in the same environment. However, little is known about circuit or anatomical origins of this individuality. Here, we demonstrate a neural correlate Drosophila odor preference behavior olfactory sensory periphery. Namely, idiosyncratic calcium responses projection neuron (PN) dendrites and densities presynaptic protein Bruchpilot receptor (ORN) axon terminals with individual preferences choice between two aversive odorants. The ORN-PN synapse appears to be locus individuality where microscale variation gives rise behavior. Simulating stochasticity synapses 3,062 model antennal lobe recapitulates patterns PN matching experiments. Conversely, other compartments does not recapitulate those patterns. Our results how physiological structural variations can give behavior, when genetics environment are held constant.

Язык: Английский

Процитировано

0
A neural correlate of individual odor preference in Drosophila DOI Creative Commons
Matthew A. Churgin, Danylo Lavrentovich, M. A. Smith

и другие.

eLife, Год журнала: 2025, Номер 12

Опубликована: Март 11, 2025

Behavior varies even among genetically identical animals raised in the same environment. However, little is known about circuit or anatomical origins of this individuality. Here, we demonstrate a neural correlate Drosophila odor preference behavior olfactory sensory periphery. Namely, idiosyncratic calcium responses projection neuron (PN) dendrites and densities presynaptic protein Bruchpilot receptor (ORN) axon terminals with individual preferences choice between two aversive odorants. The ORN-PN synapse appears to be locus individuality where microscale variation gives rise behavior. Simulating stochasticity synapses 3062 model antennal lobe recapitulates patterns PN matching experiments. Conversely, other compartments does not recapitulate those patterns. Our results how physiological structural variations can give behavior, when genetics environment are held constant.

Язык: Английский

Процитировано

0
The Budding Neuroscience of Ant Social Behavior DOI

Dominic D. Frank,

Daniel J. C. Kronauer

Annual Review of Neuroscience, Год журнала: 2024, Номер 47(1), С. 167 - 185

Опубликована: Апрель 11, 2024

Ant physiology has been fashioned by 100 million years of social evolution. Ants perform many sophisticated and collective behaviors yet possess nervous systems similar in schematic scale to that the fruit fly Drosophila melanogaster, a popular solitary model organism. are thus attractive complementary subjects investigate adaptations pertaining complex absent flies. Despite research interest ant behavior neurobiological foundations sociality more broadly, our understanding system is incomplete. Recent technical advances have enabled cutting-edge investigations fashion less dependent on choice, opening door for mechanistic insect neuroscience. In this review, we revisit important aspects what known about behavior, look forward how functional circuit neuroscience ants will help us understand distinguishes animals from highly ones.

Язык: Английский

Процитировано

3
Brain bilateral asymmetry – insights from nematodes, zebrafish, and Drosophila DOI
François Lapraz, Cloé Fixary-Schuster, Stéphane Noselli

и другие.

Trends in Neurosciences, Год журнала: 2024, Номер 47(10), С. 803 - 818

Опубликована: Сен. 24, 2024

Язык: Английский

Процитировано

3
Sex-specific competitive social feedback amplifies the role of early life contingency in male mice DOI Creative Commons
Matthew N. Zipple,

Daniel Chang Kuo,

Xinmiao Meng

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 21, 2024

Abstract Contingency (or ‘luck’) in early life plays an important role shaping individuals’ development. When individuals live within larger societies, social experiences may cause the importance of contingencies to be magnified or dampened. Here we test hypothesis that competition magnifies contingency a sex-specific manner by comparing developmental trajectories genetically identical, free-living mice who either experienced high levels territorial (males) did not (females). We show male territoriality results competitive feedback loop and pushes onto divergent, self-reinforcing trajectories, while same process appears absent females. Our indicate strength sexual selection self-limiting, as within-sex increases contingency, thereby reducing ability lead evolution. They also demonstrate potential for dramatic differences outcomes, even absence any underlying (‘merit’).

Язык: Английский

Процитировано

2
Uncovering multiscale structure in the variability of larval zebrafish navigation DOI Creative Commons
Gautam Sridhar, Massimo Vergassola, João C. Marques

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(47)

Опубликована: Ноя. 15, 2024

Animals chain movements into long-lived motor strategies, exhibiting variability across scales that reflects the interplay between internal states and environmental cues. To reveal structure in such variability, we build Markov models of movement sequences bridge timescales enable a quantitative comparison behavioral phenotypes among individuals. Applied to larval zebrafish responding diverse sensory cues, uncover hierarchy dominated by changes orientation distinguishing cruising versus wandering strategies. Environmental cues induce preferences along these modes at population level: while fish cruise light, they wander response aversive stimuli, or search for appetitive prey. As our method encodes dynamics each individual transitions coarse-grained use it hierarchical phenotypic exploration–exploitation trade-offs. Across wide range major source variation is driven prior and/or immediate exposure prey induces exploitation phenotypes. A large degree not explained unravels hidden override context contrasting Altogether, extracting strategies deployed during navigation, approach exposes individuals reveals tuned experience.

Язык: Английский

Процитировано

2
Driver lines for studying associative learning in Drosophila DOI Open Access
Yichun Shuai, Megan Sammons, Gabriella R Sterne

и другие.

Опубликована: Ноя. 5, 2024

The mushroom body (MB) is the center for associative learning in insects. In Drosophila , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid foundation precise interrogation of MB neural circuits. However, investigation many cell types upstream downstream has been hindered due to lack specific driver lines. Here we describe a new collection over 800 split-LexA that cover approximately 300 types, including sugar sensory neurons, putative nociceptive ascending olfactory thermo-/hygro-sensory projection interneurons connected with MB-extrinsic various other types. We characterized activation phenotypes subset these lines identified neuron line most suitable reward substitution. Leveraging thousands confocal images associated collection, analyzed neuronal morphological stereotypy discovered one set output MBON08/MBON09, exhibits striking individuality asymmetry across animals. conjunction EM connectome maps, reported here offer powerful resource functional dissection circuits adult .

Язык: Английский

Процитировано

1
Neural correlates of individual odor preference in Drosophila DOI Open Access
Matthew A. Churgin, Danylo Lavrentovich, M. A. Smith

и другие.

Опубликована: Окт. 17, 2023

Behavior varies even among genetically identical animals raised in the same environment. However, little is known about circuit or anatomical origins of this individuality. We show individual Drosophila odor preferences (odor-vs-air and odor-vs-odor) are predicted by idiosyncratic calcium dynamics olfactory receptor neurons (ORNs) projection (PNs), respectively. Variation ORN presynaptic density also predicts odor-vs-odor preference. The ORN-PN synapse appears to be a locus individuality where microscale variation gives rise behavior. Finally, simulating stochasticity synapses 3,062 neuron model antennal lobe recapitulates patterns PN responses matching experiments. Our results demonstrate how physiological structural variations can give behavior, when genetics environment held constant.

Язык: Английский

Процитировано

3
A neural correlate of individual odor preference inDrosophila DOI Creative Commons
Matthew A. Churgin, Danylo Lavrentovich, M. A. Smith

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Дек. 24, 2021

Abstract Behavior varies even among genetically identical animals raised in the same environment. However, little is known about circuit or anatomical origins of this individuality. Here, we demonstrate a neural correlate Drosophila odor preference behavior olfactory sensory periphery. Namely, idiosyncratic calcium responses projection neuron (PN) dendrites and densities presynaptic protein Bruchpilot receptor (ORN) axon terminals with individual preferences choice between two aversive odorants. The ORN-PN synapse appears to be locus individuality where microscale variation gives rise behavior. Simulating stochasticity synapses 3,062 model antennal lobe recapitulates patterns PN matching experiments. Conversely, other compartments does not recapitulate those patterns. Our results how physiological structural variations can give behavior, when genetics environment are held constant.

Язык: Английский

Процитировано

7
Scalable Apparatus to Measure Posture and Locomotion (SAMPL): a high-throughput solution to study unconstrained vertical behavior in small animals DOI Creative Commons
Yunlu Zhu, Franziska Auer, Hannah Gelnaw

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Янв. 7, 2023

Balance and movement are impaired in a wide variety of neurological disorders. Recent advances behavioral monitoring provide unprecedented access to posture locomotor kinematics, but without the throughput scalability necessary screen candidate genes / potential therapeutics. We present powerful solution: Scalable Apparatus Measure Posture Locomotion (SAMPL). SAMPL includes extensible imaging hardware low-cost open-source acquisition software with real-time processing. first demonstrate that SAMPL's can acquire data from D. melanogaster, C. elegans, rerio as they move vertically. Next, we leverage rapidly (two weeks) gather new zebrafish dataset. use analysis visualization tools replicate extend our current understanding how balance navigate through vertical environment. discover (1) key kinematic parameters vary systematically genetic background, (2) such background variation is small relative changes accompany early development. Finally, simulate ability resolve differences or navigation function affect size gathered -- for screens. Taken together, apparatus, data, solution labs using animals investigate disorders at scale. More broadly, both an adaptable resource looking process videographic measures behavior real-time, exemplar scale enable screening.

Язык: Английский

Процитировано

2