Next-Generation Cognitive-Behavioral Therapy for Depression: Integrating Digital Tools, Teletherapy, and Personalization for Enhanced Mental Health Outcomes

Medicina, Год журнала: 2025, Номер 61(3), С. 431 - 431

Опубликована: Фев. 28, 2025

Background and Objectives: This systematic review aims to present the latest developments in next-generation CBT interventions of digital support tools, teletherapies, personalized treatment modules enhancing accessibility, improving adherence, optimizing therapeutic outcomes for depression. Materials Methods: analyzed 81 PRISMA-guided studies on efficacy, feasibility, applicability NG-CBT approaches. Other important innovations include web-based interventions, AI-operated chatbots, teletherapy platforms, each which serves as a critical challenge delivering mental health care. Key messages have emerged regarding technological readiness, patient engagement, changing role therapists within context Results: Findings indicate that improve accessibility engagement while maintaining clinical effectiveness. Personalized tools enhance platforms provide scalable cost-effective alternatives traditional therapy. Conclusions: Such promise great avenues decreasing global burden depression quality life through novel, accessible, high-quality

Язык: Английский

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Environmental enrichment: a systematic review on the effect of a changing spatial complexity on hippocampal neurogenesis and plasticity in rodents, with considerations for translation to urban and built environments for humans

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июнь 11, 2024

Hippocampal neurogenesis is critical for improving learning, memory, and spatial navigation. Inhabiting navigating complexity key to stimulating adult hippocampal (AHN) in rodents because they share similar neuroplasticity characteristics with humans. AHN humans has recently been found persist until the tenth decade of life, but it declines aging influenced by environmental enrichment. This systematic review investigated impact on plasticity rodents, discussed translatability these findings human interventions.

Язык: Английский

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The first rodent behavioral study (1822) and the diffusion of human-bred albino rats and mice in the 19th century

Frontiers in Psychology, Год журнала: 2025, Номер 15

Опубликована: Фев. 3, 2025

Rodents, in particular rats and mice, are currently the most widely employed animal models psychology behavioral neuroscience. Nevertheless, an interesting historical question is: when was first rodent study performed by whom? The current article presents history of science: a case interspecies social bonding between rat dog, observed 1822 British chemist Samuel Moss (1794–1868) subsequently described same scientific 1836. In present article, after biographical sketch Moss, I examine detail notable Moss. This is under several points view. First, Moss’s albino, variety which at that time extremely rare. Moreover, time, Western world were mostly seen as pest animals or baits for rat-catching sports, not kept pets. color played key role its fate, being reason it originally brought to decided keep his care. Third, relationship arose dog even more surprising if we consider trained rat-catcher. Importantly, this rat-dog case, showcased tameness albino both lay publications, represented popularization docility rats. After having outlined considering importance our society, research (where has become prototype laboratory rat) pets, provide contextualization regarding rodents, starting from 17th century, then trace post-Moss diffusion human-bred mice 19th century.

Язык: Английский

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Time Perception Test in IntelliCage System for Preclinical Study: Linking Depression and Serotonergic Modulation

Diagnostics, Год журнала: 2025, Номер 15(2), С. 151 - 151

Опубликована: Янв. 10, 2025

Background/Objectives:: The link between serotonergic modulation and depression is under debate; however, serotonin reuptake inhibitors (SRIs) are still the first-choice medicine in this condition. Disturbances time perception also reported with one of behavioral schedules used to study interval timing, differential-reinforcement-learning-of-low-rate, having been shown have high predictive validity for an antidepressant effect. Here, we introduce IntelliCage research protocol bisection task that allows more ecologically valid less time-consuming rodent examination provides example its use confirm previously acute effect SRI, clomipramine, on timing (increase point, D50). Methods: Wistar male rats (n = 25, five groups 5-8) were trained discriminate short (1 s) long (4 LED light stimuli by nose poking at corresponding (left/right) side chamber obtain a drink. When 80% correct responses reached, intermediate durations 1.7, 2.5, 3.3 s introduced. number left/right choices each stimulus parameters (bisection D50, precision), derived from them, compared after saline clomipramine (7 mg/kg, i.p) intraperitoneal administration. Results: Rats successfully learned within about week training. slightly increased D50 confirmed previous studies. Conclusions: introduced has potential be applicable preclinical potentially other psychopathology, where can disturbed.

Язык: Английский

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Robotic animals as new tools in rodent neuroscience research: proposed applications of zooinspired robots for mouse behavioral testing

Frontiers in Behavioral Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 24, 2025

Bioinspired robots are machines which reproduce structural or functional features of a living organism. In particular, the bioinspired animals can be more specifically defined as zooinspired robots. Currently, applications animal various and range across different fields, such as, for instance, nature conservation, search rescue humans after natural man-made disasters, exploration extraterrestrial environments robotic pets elderly people under care dementia. Several species have been imitated up to now, from lizards butterflies, fish dogs. Animal used investigate social behavior an through animal-robot interactions called ethorobots. Intriguingly, ethorobots able in laboratory behaviors that generally produced spontaneously difficult impossible evoke modulate captive animals, makes these particularly useful tools experimental ethology ethological neuroscience. Rodents, primarily mice rats, most common model biomedical research. Coherently with importance scientific research, rats attracting increasing efforts robotics over course past five decades. The technological advancement will make their employment research increasingly useful. However, clear should identified order challenge engineers design serve scopes. present work, we describe possible practical mouse behavioral testing six domains, namely courtship, parental care, antipredatory behavior, helping predation territory defense-related aggression. outline how could employed interact series specific tests behavior. Finally, conclusion consider ethical epistemological advantages use Indeed, benefit on both terms optimized welfare tested subjects extended opportunities designing due unprecedented control independent variables.

Язык: Английский

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A comprehensive and standardized pipeline for automated profiling of higher cognition in mice

Cell Reports Methods, Год журнала: 2025, Номер unknown, С. 101011 - 101011

Опубликована: Март 1, 2025

Язык: Английский

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Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community

Cell Reports Methods, Год журнала: 2025, Номер unknown, С. 101024 - 101024

Опубликована: Апрель 1, 2025

Existing models of frontotemporal dementia (FTD) may not fully recapitulate the pathophysiology disease. To generate more pathophysiologically relevant FTD models, we engineered MAPT knockin mouse lines carrying triple mutations, among which MAPTP301S;Int10+3;S320F line exhibited robust tau pathology starting before 6 months age. Severe accumulation was predominantly observed in thalamus, hypothalamus, and amygdala with milder involvement cortex hippocampus, leading to synaptic loss, brain atrophy, FTD-like behavioral abnormalities. Crossbreeding mice App knockin, AppNL-G-F, markedly enhanced highlighting interplay between β-amyloid tau. These findings establish mutant as valuable for investigating mechanisms underlying other tauopathies, providing a platform vivo drug screening.

Язык: Английский

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Automated Behavioral Analysis of Schizophrenia-like Phenotypes in Repeated MK-801-Treated Mice Using IntelliCage

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5184 - 5184

Опубликована: Май 28, 2025

Schizophrenia is a psychiatric disorder characterized by positive, negative, and cognitive symptoms. MK-801, an N-methyl-D-aspartate receptor antagonist, has been used to induce schizophrenia-like behaviors in animal models. Here, we employed IntelliCage, automated system for tracking behavior, assess MK-801-treated mice under semi-naturalistic conditions. Mice that had treated with MK-801 2 weeks were analyzed locomotion, emotional, functions. Repeated exhibited transient hyperactivity novel environment, without significant changes overall circadian activity. Sucrose preference remained intact, suggesting preserved reward sensitivity. However, less time spent the corner during early phase of competition test indicated reduced competitive behavior limited water rewards. In behavioral flexibility test, repeated showed impaired reversal learning, flexibility, although acquisition initial place discrimination was comparable observed control mice. These impairments parallel core symptoms schizophrenia, particularly social domains. Our findings demonstrate utility IntelliCage detecting phenotypes over prolonged periods group-housed settings. This study provides ecologically valid platform assessing may facilitate development translationally relevant therapeutic interventions.

Язык: Английский

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Neuroeducación y Medicina Conductual: Herramientas Indispensables para mejorar la Calidad de Vida en Hospitales y en Casa

Ciencia Latina Revista Científica Multidisciplinar, Год журнала: 2024, Номер 8(1), С. 10081 - 10091

Опубликована: Апрель 8, 2024

Se hace un repaso por los principales aspectos históricos y técnicos sobre dos importantes disciplinas científicas: la medicina conductual neuroeducación aplicadas al mejoramiento de calidad vida pacientes en entornos hospitalarios clínicos, pues se considera que son campos tienen muchas herramientas para aportar significativamente a procesos recuperación personas requieren amplios seguimientos acompañamientos desde sus sistemas autocontrol autorregulación puedan llevar cabo, programas mucho más efectivos tener una disciplina con su salud física, emocional psicológica. La ejecución este estudio, enfocó hacer lectura detallada profundidad logros hallazgos realizados todo tipo patologías cuadros diagnósticos alta complejidad. Como conclusiones ha encontrado que, estas amplia experiencia 40 años contribuir ayudar reforzamiento apoyo psicoemocional el hogar las recomendaciones sugerencias médicos especialistas ejecutarse cabalidad, llegando evidenciarse cuando no cuenta respaldo alguna disciplinas, pacientes, tiende ralentizarse decaer progresivamente.

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Single MAPT knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research community

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 15, 2024

Abstract We recently reported development of human MAPT knock-in mice that carry single or double pathogenic mutations frontotemporal dementia. However, it takes more than 14 months for the line with most aggressive phenotypes to exhibit tau pathology without forming high-order oligomers, along concomitant abnormal behavior. thus generated carrying triple mutations, among which P301S;Int10+3;S320F exhibited robust starting earlier 6 months. Tau accumulation took place mainly in thalamus, hypothalamus, amygdala and entorhinal cortex, but less so hippocampus, leading synaptic loss, atrophy behavioral abnormalities. Crossbreeding App NL-G-F resulted manifestation hippocampus cortex. These mutant will be valuable tools understanding mechanisms dementia, Alzheimer’s disease other tauopathies.

Язык: Английский

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