Oral manifestations and prognosis of COVID-19 positive population in Suining City in the post-epidemic era DOI Open Access

Tengmin Gao,

Wang Yi-gui,

Lijuan Guo

и другие.

Authorea (Authorea), Год журнала: 2023, Номер unknown

Опубликована: Авг. 31, 2023

Objectives: To investigate the oral symptoms of COVID-19 ’s “positive” group in Suining City after comprehensive liberalization epidemic prevention and control measures China. explore related influencing factors symptom differences provide reference for treatment patients post-epidemic era. Methods: An online survey based on a random sample 25 questions. Results: 1768 valid questionnaires were collected. The data showed that 363 people had problems an infection with novel coronavirus. SARS‐CoV‐2 mainly focused gingiva swelling or bleeding (38.57%), toothache (37.74%), bad breath (27.55%), ulcer (30.30%), abnormal taste (24.24%) some infected variety symptoms. A small number also have other problems. incidence was significantly correlated sex, age, educational level, place residence, smoking, basic diseases, long-term saline gargle vaccination vaccine. In addition, smoking history, significant prognosis. Conclusions: era, most common are bleeding, toothache, breath, ulcer, taste. And maintaining good living habits is basis promoting disease recovery health.

Язык: Английский

The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage DOI
Mitra Rostami,

Pouria Farahani,

Samar Esmaelian

и другие.

Stem Cell Reviews and Reports, Год журнала: 2024, Номер 20(8), С. 2062 - 2103

Опубликована: Авг. 16, 2024

Язык: Английский

Процитировано

4
Unveiling the Oral Lesions, Dysgeusia and Osteonecrosis Related to COVID-19: A Comprehensive Systematic Review DOI Open Access

Angelo Aliberti,

Roberta Gasparro,

Martina Mignogna

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1267 - 1267

Опубликована: Фев. 14, 2025

Background/Objectives: The oral cavity has garnered increasing attention as a site for viral infection and related pathological manifestations in coronavirus disease-19. This article aims to provide comprehensive overview of SARS-CoV-2 (severe acute respiratory syndrome 2)-related manifestations, including taste disturbances, lesions osteonecrosis. Methods: A search was conducted up September 2024 according PRISMA (Preferred Reporting Items Systematic Reviews) guidelines using the databases PubMed Scopus. All observational, case-series, case-report cross-sectional studies written English on COVID-19 disease long-COVID were included. other types based manifestation after vaccination impairment due lockdown excluded. risk bias included assessed Joanna Briggs Appraisal checklist. Results: total 104 articles 23 case-report, 15 8 case-control, 18 cohort 40 selected. results showed that patients with found have significantly higher prevalence xerostomia (45-74%) dysgeusia (32-59%) compared non-infected individuals. Regarding mucosal lesions, ulcers, candidiasis herpes simplex infections frequently observed. As osteonecrosis, significant number COVID-19-associated rhinomaxillary mucormycosis presented maxillary osteonecrosis fungal infection, primarily mucormycosis. methodological quality most moderate/high. Conclusions: been associated range manifestations. complex interplay immune response, medication use stress likely contributes these complications. Early recognition management are crucial improving patient outcomes developing targeted preventive therapeutic strategies COVID-19-related health issues.

Язык: Английский

Процитировано

0
Impact of Symptomatic COVID-19 on the Oral Health of Pediatric Patients in Tbilisi City DOI Creative Commons
Lia Mania, Ketevan Nanobashvili, Tinatin Manjavidze

и другие.

Children, Год журнала: 2025, Номер 12(6), С. 725 - 725

Опубликована: Май 31, 2025

Background/Purpose: Coronavirus disease 2019 (COVID-19) has become the cause of a global health crisis during pandemic. This research aimed to study impact symptomatic COVID-19 on children’s oral indices and salivary microbiome composition post-COVID-19 period. Methods: An observational, cross-sectional was conducted in Tbilisi (Georgia) among children aged 7–12 years. A total 421 included had history laboratory-confirmed within one year exposure. No participants met criteria for comorbid conditions or PCC. stratified simple random selection schools selected clusters used. The were divided into two groups: exposed group, who patients with COVID-19, control asymptomatic COVID-19. data collected from August 2022 December 2023. Oral screening, microbiological examination saliva, administration questionnaires also performed. Logistic regression used calculate ORs 95% confidence intervals. statistical processing performed SPSS 23.0. approved by Biomedical Research Ethical Council University Georgia (UGREC–04–22/9 March 2022). Results: Statistically significant differences means indicators between studied groups detected (exposed: DMFT + deft = 5.9; MGI 0.92; S-OHI 1.9; control: 3.8; 0.56; 1.4). According logistic regression, effect following indicators: (OR 1.26; CI 1.14–1.39), 2.31; 1.50–3.55), 3.43; 2.03–5.76). frequency eradication 2.12; 1.23–3.63). Conclusions: close association established changes saliva children, as well Considering results, it is assumed that course may be an additional risk factor associated poor pediatric population

Язык: Английский

Процитировано

0
Identification of receptors and factors associated with human coronaviruses in the oral cavity using single-cell RNA sequencing DOI Creative Commons
Feng Gao, Wei-Ming Lin, Xia Wang

и другие.

Heliyon, Год журнала: 2024, Номер 10(7), С. e28280 - e28280

Опубликована: Март 16, 2024

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) ravaged the world, and Coronavirus Disease 2019 (COVID-19) exhibited highly prevalent oral symptoms that had significantly impacted lives of affected patients. However, involvement four human coronavirus (HCoVs), namely SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-229E, in cavity infections remained poorly understood. We integrated single-cell RNA sequencing (scRNA-seq) data seven tissues through consistent normalization procedure, including minor salivary gland (MSG), parotid (PG), tongue, gingiva, buccal, periodontium pulp. The Seurat, scDblFinder, Harmony, SingleR, Ucell scCancer packages were comprehensively used for analysis. identified specific cell clusters generated expression profiles SARS-CoV-2 coronavirus-associated receptors factors (SCARFs) regions, providing direction predicting tropism HCoVs tissues, as well dental clinical treatment. Based on our analysis, it appears various SCARFs, ACE2, ASGR1, KREMEN1, DPP4, ANPEP, CD209, CLEC4G/M, TMPRSS family proteins (including TMPRSS2, TMPRSS4, TMPRSS11A), FURIN, are expressed at low levels cavity. Conversely, BSG, CTSB, CTSL exhibit enrichment tissues. Our study also demonstrates widespread restriction factors, particularly IFITM1-3 LY6E, cells. Additionally, some replication, assembly, trafficking appear to broad patterns. Overall, could potentially serve a high-risk site infection, while displaying comparatively lower degree susceptibility towards other MERS-CoV HCoV-229E). Specifically, MSG, gingiva represent potential sites vulnerability with MSG exhibiting high susceptibility. patterns SCARFs demonstrate relatively intricate may only be specifically associated infection. sheds light mechanisms infection gains insight into characteristics distribution possible target cells therapeutic targets

Язык: Английский

Процитировано

1
Prevalence and association of oral manifestations with disease severity in patients diagnosed with COVID‑19: A cross‑sectional study DOI Creative Commons

Adriana-Teodora Campeanu,

Mihaela Rus,

Sorina Ispas

и другие.

Medicine International, Год журнала: 2024, Номер 4(3)

Опубликована: Апрель 10, 2024

Systemic disorders may exhibit early signs when conducting an oral examination. Since the onset of COVID‑19 pandemic, several studies have been published detailing direct impact virus on cavity. The present study aimed to determine whether indeed there are any significant disparities in oropharyngeal manifestations between individuals infected with severe acute respiratory syndrome coronavirus 2 and a control group, has ability invade reproduce inside keratinocytes fibroblasts, resulting development ulcerations superficial lesions. provides overview symptoms that occur at stage illness, most commonly affected regions cavity, including tongue, lips, palate oropharynx examined. In retrospective study, 52 patients were recruited April, 2021 October, 2022. addition, who tested negative for as group. was conducted through thorough examination questionnaire provided all participants. results revealed among cohort from group examined (n=52), proportion (mean, 16.15) displayed manifestations. Specifically, 75% described cavity pain, 69% these had changes teeth color or dental caries. summary, relation prevalence generally lower compared apart pain (30.8%), tonsillitis (17.3%), bleeding (34.6%), (36.5%), recurrence (15.4%) abscesses (7.7%). Thus, whole, without fewer

Язык: Английский

Процитировано

1
COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic DOI Creative Commons
Luigi Bellocchio, Gianna Dipalma, Angelo Michele Inchingolo

и другие.

Biomedicines, Год журнала: 2023, Номер 12(1), С. 60 - 60

Опубликована: Дек. 26, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by droplets aerosols from the oral cavity (O.C.) of infected subjects, as stated World Health Organization. Saliva also retains viral particles aids in spread COVID-19. Angiotensin-converting enzyme Type (ACE2) transmembrane serine protease (TMPRSS2) two numerous factors that promote SARS-CoV-2 infection, expressed O.C. structures, various mucosa types, epithelia salivary glands. A systemic might result replication cells. On other hand, cellular damage different subtypes associated with clinical signs symptoms. Factors interfering potential represent fertile ground for possible local pharmacotherapeutic interventions, which may confine virus entry O.C., finally representing a way reduce COVID-19 incidence severity.

Язык: Английский

Процитировано

3
Insights into estrogen impact in oral health & microbiome in COVID-19 DOI Creative Commons
Rubén Alberto Bayardo González, Marcela Peña‐Rodríguez, Ana Laura Pereira-Suárez

и другие.

BMC Microbiology, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 20, 2024

Язык: Английский

Процитировано

0
The Mouth as a Site of SARS-CoV-2 Infection DOI Creative Commons
Natalie Atyeo, Paola Pérez, Bruno Fernandes Matuck

и другие.

Current Oral Health Reports, Год журнала: 2024, Номер 11(2), С. 167 - 176

Опубликована: Фев. 21, 2024

Abstract Purpose of Review During the height coronavirus pandemic, oral cavity was recognized as a critically important site for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The purpose this review is to analyze literature surrounding SARS-CoV-2 entry, replication, and transmission resulting impact on host tissues in cavity. Recent Findings detection viral genetic material saliva allows widespread surveillance testing emphasizes importance through shed saliva. As cohort patients who have recovered from infection grows, several questions remain about long-term impacts tissues, including whether may serve persistent reservoir. Therefore, thorough understanding life cycle diverse warranted. We conclude with broad outlook effects how these relate post-acute sequelae experienced by patients. Summary can enter replicate be spread between individuals via Several manifestations been reported, lingering are an area ongoing investigation.

Язык: Английский

Процитировано

0
Comparison of Oral Manifestations in Hospitalized COVID-19 Positive Patients and COVID-19 Negative Dental Outpatients. A Case Series Study and Literature Review DOI Open Access

Flora Zervou-Valvi,

Emmanouil M. Valvis,

Angeliki Giannopoulou

и другие.

International Journal of Otolaryngology and Head &amp Neck Surgery, Год журнала: 2024, Номер 13(03), С. 225 - 250

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Manifestações clínicas bucais relacionada a COVID-19 DOI Open Access

Auzileia Miranda Ferreira,

Lucas Francisco Arruda Mendonça, Nayhane Cristine da Silva de Oliveira

и другие.

Brazilian Journal of Health Review, Год журнала: 2024, Номер 7(3), С. e70093 - e70093

Опубликована: Май 31, 2024

Introdução: A síndrome respiratória aguda grave por coronavírus 2 (SARS-CoV-2) é capaz de manifestar alterações bucais em virtude do seu principal alvo ser o receptor da enzima conversora angiotensina (ACE2), que encontrado grandes quantidades na mucosa oral. Objetivo: fornecer um resumo das principais manifestações orais pacientes com COVID 19. Metodologia: realizou-se uma revisão narrativa literatura nas bases dados científico internacionais Google Acadêmico e PubMed Medline janeiro 2020 a 2024. Revisão: SARS-CoV-2 vírus ARN cadeia única responsável pela doença coronavírus. Pacientes infectados pelo apresentam os sintomas clínicos disgeusia, febre, cefaleia (dor cabeça), odinofagia garganta), dispneia (falta ar), tosse seca, epigastralgia abdominal), vômito diarreia. Conclusão: Lesões aftosas, herpetiformes, placas pseudomembranosas, lesões avermelhadas, lábios fissurados secos língua enantematosa papilas proeminentes são as mais comuns COVID-19.

Процитировано

0