Oral manifestations and prognosis of COVID-19 positive population in Suining City in the post-epidemic era DOI Open Access

Tengmin Gao,

Wang Yi-gui,

Lijuan Guo

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 31, 2023

Objectives: To investigate the oral symptoms of COVID-19 ’s “positive” group in Suining City after comprehensive liberalization epidemic prevention and control measures China. explore related influencing factors symptom differences provide reference for treatment patients post-epidemic era. Methods: An online survey based on a random sample 25 questions. Results: 1768 valid questionnaires were collected. The data showed that 363 people had problems an infection with novel coronavirus. SARS‐CoV‐2 mainly focused gingiva swelling or bleeding (38.57%), toothache (37.74%), bad breath (27.55%), ulcer (30.30%), abnormal taste (24.24%) some infected variety symptoms. A small number also have other problems. incidence was significantly correlated sex, age, educational level, place residence, smoking, basic diseases, long-term saline gargle vaccination vaccine. In addition, smoking history, significant prognosis. Conclusions: era, most common are bleeding, toothache, breath, ulcer, taste. And maintaining good living habits is basis promoting disease recovery health.

Language: Английский

Unveiling the Oral Lesions, Dysgeusia and Osteonecrosis Related to COVID-19: A Comprehensive Systematic Review DOI Open Access

Angelo Aliberti,

Roberta Gasparro,

Martina Mignogna

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1267 - 1267

Published: Feb. 14, 2025

Background/Objectives: The oral cavity has garnered increasing attention as a site for viral infection and related pathological manifestations in coronavirus disease-19. This article aims to provide comprehensive overview of SARS-CoV-2 (severe acute respiratory syndrome 2)-related manifestations, including taste disturbances, lesions osteonecrosis. Methods: A search was conducted up September 2024 according PRISMA (Preferred Reporting Items Systematic Reviews) guidelines using the databases PubMed Scopus. All observational, case-series, case-report cross-sectional studies written English on COVID-19 disease long-COVID were included. other types based manifestation after vaccination impairment due lockdown excluded. risk bias included assessed Joanna Briggs Appraisal checklist. Results: total 104 articles 23 case-report, 15 8 case-control, 18 cohort 40 selected. results showed that patients with found have significantly higher prevalence xerostomia (45-74%) dysgeusia (32-59%) compared non-infected individuals. Regarding mucosal lesions, ulcers, candidiasis herpes simplex infections frequently observed. As osteonecrosis, significant number COVID-19-associated rhinomaxillary mucormycosis presented maxillary osteonecrosis fungal infection, primarily mucormycosis. methodological quality most moderate/high. Conclusions: been associated range manifestations. complex interplay immune response, medication use stress likely contributes these complications. Early recognition management are crucial improving patient outcomes developing targeted preventive therapeutic strategies COVID-19-related health issues.

Language: Английский

Citations

0
The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage DOI
Mitra Rostami,

Pouria Farahani,

Samar Esmaelian

et al.

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(8), P. 2062 - 2103

Published: Aug. 16, 2024

Language: Английский

Citations

3
Identification of receptors and factors associated with human coronaviruses in the oral cavity using single-cell RNA sequencing DOI Creative Commons
Feng Gao, Wei-Ming Lin, Xia Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28280 - e28280

Published: March 16, 2024

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) ravaged the world, and Coronavirus Disease 2019 (COVID-19) exhibited highly prevalent oral symptoms that had significantly impacted lives of affected patients. However, involvement four human coronavirus (HCoVs), namely SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-229E, in cavity infections remained poorly understood. We integrated single-cell RNA sequencing (scRNA-seq) data seven tissues through consistent normalization procedure, including minor salivary gland (MSG), parotid (PG), tongue, gingiva, buccal, periodontium pulp. The Seurat, scDblFinder, Harmony, SingleR, Ucell scCancer packages were comprehensively used for analysis. identified specific cell clusters generated expression profiles SARS-CoV-2 coronavirus-associated receptors factors (SCARFs) regions, providing direction predicting tropism HCoVs tissues, as well dental clinical treatment. Based on our analysis, it appears various SCARFs, ACE2, ASGR1, KREMEN1, DPP4, ANPEP, CD209, CLEC4G/M, TMPRSS family proteins (including TMPRSS2, TMPRSS4, TMPRSS11A), FURIN, are expressed at low levels cavity. Conversely, BSG, CTSB, CTSL exhibit enrichment tissues. Our study also demonstrates widespread restriction factors, particularly IFITM1-3 LY6E, cells. Additionally, some replication, assembly, trafficking appear to broad patterns. Overall, could potentially serve a high-risk site infection, while displaying comparatively lower degree susceptibility towards other MERS-CoV HCoV-229E). Specifically, MSG, gingiva represent potential sites vulnerability with MSG exhibiting high susceptibility. patterns SCARFs demonstrate relatively intricate may only be specifically associated infection. sheds light mechanisms infection gains insight into characteristics distribution possible target cells therapeutic targets

Language: Английский

Citations

1
Prevalence and association of oral manifestations with disease severity in patients diagnosed with COVID‑19: A cross‑sectional study DOI Creative Commons

Adriana-Teodora Campeanu,

Mihaela Rus,

Sorina Ispas

et al.

Medicine International, Journal Year: 2024, Volume and Issue: 4(3)

Published: April 10, 2024

Systemic disorders may exhibit early signs when conducting an oral examination. Since the onset of COVID‑19 pandemic, several studies have been published detailing direct impact virus on cavity. The present study aimed to determine whether indeed there are any significant disparities in oropharyngeal manifestations between individuals infected with severe acute respiratory syndrome coronavirus 2 and a control group, has ability invade reproduce inside keratinocytes fibroblasts, resulting development ulcerations superficial lesions. provides overview symptoms that occur at stage illness, most commonly affected regions cavity, including tongue, lips, palate oropharynx examined. In retrospective study, 52 patients were recruited April, 2021 October, 2022. addition, who tested negative for as group. was conducted through thorough examination questionnaire provided all participants. results revealed among cohort from group examined (n=52), proportion (mean, 16.15) displayed manifestations. Specifically, 75% described cavity pain, 69% these had changes teeth color or dental caries. summary, relation prevalence generally lower compared apart pain (30.8%), tonsillitis (17.3%), bleeding (34.6%), (36.5%), recurrence (15.4%) abscesses (7.7%). Thus, whole, without fewer

Language: Английский

Citations

1
COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic DOI Creative Commons
Luigi Bellocchio, Gianna Dipalma, Angelo Michele Inchingolo

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 12(1), P. 60 - 60

Published: Dec. 26, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by droplets aerosols from the oral cavity (O.C.) of infected subjects, as stated World Health Organization. Saliva also retains viral particles aids in spread COVID-19. Angiotensin-converting enzyme Type (ACE2) transmembrane serine protease (TMPRSS2) two numerous factors that promote SARS-CoV-2 infection, expressed O.C. structures, various mucosa types, epithelia salivary glands. A systemic might result replication cells. On other hand, cellular damage different subtypes associated with clinical signs symptoms. Factors interfering potential represent fertile ground for possible local pharmacotherapeutic interventions, which may confine virus entry O.C., finally representing a way reduce COVID-19 incidence severity.

Language: Английский

Citations

3
Insights into estrogen impact in oral health & microbiome in COVID-19 DOI Creative Commons
Rubén Alberto Bayardo González, Marcela Peña‐Rodríguez, Ana Laura Pereira-Suárez

et al.

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 20, 2024

Language: Английский

Citations

0
The Mouth as a Site of SARS-CoV-2 Infection DOI Creative Commons
Natalie Atyeo, Paola Pérez, Bruno Fernandes Matuck

et al.

Current Oral Health Reports, Journal Year: 2024, Volume and Issue: 11(2), P. 167 - 176

Published: Feb. 21, 2024

Abstract Purpose of Review During the height coronavirus pandemic, oral cavity was recognized as a critically important site for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The purpose this review is to analyze literature surrounding SARS-CoV-2 entry, replication, and transmission resulting impact on host tissues in cavity. Recent Findings detection viral genetic material saliva allows widespread surveillance testing emphasizes importance through shed saliva. As cohort patients who have recovered from infection grows, several questions remain about long-term impacts tissues, including whether may serve persistent reservoir. Therefore, thorough understanding life cycle diverse warranted. We conclude with broad outlook effects how these relate post-acute sequelae experienced by patients. Summary can enter replicate be spread between individuals via Several manifestations been reported, lingering are an area ongoing investigation.

Language: Английский

Citations

0
Comparison of Oral Manifestations in Hospitalized COVID-19 Positive Patients and COVID-19 Negative Dental Outpatients. A Case Series Study and Literature Review DOI Open Access

Flora Zervou-Valvi,

Emmanouil M. Valvis,

Angeliki Giannopoulou

et al.

International Journal of Otolaryngology and Head &amp Neck Surgery, Journal Year: 2024, Volume and Issue: 13(03), P. 225 - 250

Published: Jan. 1, 2024

Language: Английский

Citations

0
Manifestações clínicas bucais relacionada a COVID-19 DOI Open Access

Auzileia Miranda Ferreira,

Lucas Francisco Arruda Mendonça, Nayhane Cristine da Silva de Oliveira

et al.

Brazilian Journal of Health Review, Journal Year: 2024, Volume and Issue: 7(3), P. e70093 - e70093

Published: May 31, 2024

Introdução: A síndrome respiratória aguda grave por coronavírus 2 (SARS-CoV-2) é capaz de manifestar alterações bucais em virtude do seu principal alvo ser o receptor da enzima conversora angiotensina (ACE2), que encontrado grandes quantidades na mucosa oral. Objetivo: fornecer um resumo das principais manifestações orais pacientes com COVID 19. Metodologia: realizou-se uma revisão narrativa literatura nas bases dados científico internacionais Google Acadêmico e PubMed Medline janeiro 2020 a 2024. Revisão: SARS-CoV-2 vírus ARN cadeia única responsável pela doença coronavírus. Pacientes infectados pelo apresentam os sintomas clínicos disgeusia, febre, cefaleia (dor cabeça), odinofagia garganta), dispneia (falta ar), tosse seca, epigastralgia abdominal), vômito diarreia. Conclusão: Lesões aftosas, herpetiformes, placas pseudomembranosas, lesões avermelhadas, lábios fissurados secos língua enantematosa papilas proeminentes são as mais comuns COVID-19.

Citations

0
Effect of COVID-19 on oral mucosa: Literature review DOI

Shivkumari Prajapati,

Nidhi Sinha, Kunal Sah

et al.

Asian Journal of Oral Health and Allied Sciences, Journal Year: 2024, Volume and Issue: 14, P. 8 - 8

Published: June 21, 2024

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the virus that causes disease 2019, known as Corona (COVID-19). It a affects several human organs, including oral cavity. Human cells are more prone to entry of SARS-CoV-2 due extensive expression Transmembrane Proteases Serine (TMPRSS2 and TMPRSS4) angiotensin-converting enzyme II (ACE2) receptors in various bodily tissues organs. Due high ACE2 receptors, it thought cavity particularly vulnerable infection. As result, large number clinical characteristics manifestations have been reported COVID-19 cases. The symptoms COVID-19, their prevalence, succinct explanation etiology all reviewed this article.

Language: Английский

Citations

0