Journal of Chemical Neuroanatomy, Год журнала: 2022, Номер 128, С. 102229 - 102229
Опубликована: Дек. 30, 2022
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Янв. 23, 2024
The damage to the central nervous system and dysfunction of body caused by spinal cord injury (SCI) are extremely severe. pathological process SCI is accompanied inflammation nerve cells. Current evidence suggests that oxidative stress, resulting from an increase in production reactive oxygen species (ROS) imbalance its clearance, plays a significant role secondary during SCI. transcription factor nuclear erythroid 2-related 2 (Nrf2) crucial regulatory molecule for cellular redox. This review summarizes recent advancements regulation ROS-Nrf2 signaling focuses on interaction between ROS different modes neuronal cell death after SCI, such as apoptosis, autophagy, pyroptosis, ferroptosis. Furthermore, we highlight pathways through which materials science, including exosomes, hydrogels, nanomaterials, can alleviate modulating clearance. provides valuable insights directions reducing alleviating stress.
Язык: Английский
Процитировано
34
Molecular Biotechnology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 9, 2024
Язык: Английский
Процитировано
10
Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(2)
Опубликована: Янв. 1, 2025
ABSTRACT Currently, an effective treatment for spinal cord injury (SCI) is not available. Due to the irreversible primary associated with SCI, prevention and of secondary are very important. In stage, pyroptosis exacerbates deterioration injury, inhibiting beneficial recovery from SCI. The aim this study was clarify role resveratrol (RES) antipyroptotic mechanisms RES miR‐124‐3p in SCI lay a theoretical foundation clinical provide new therapeutic approaches. Using cell staining related molecular protein detection techniques assess DAPK1, effects on were investigated, injured repair rats evaluated using tissue functional experiments. vitro, DAPK1 interacts NLRP3, exerting pyroptotic effect through NLRP3/Caspase‐1/GSDMD pathway knockdown inhibits pyroptosis. miR‐124‐3P negatively regulates level reduced increased expression reduces expression, affecting vivo, GSDMD‐N levels promotes recovery, thus Therefore, we concluded that increases miR‐124‐3p, which targets pathway, alleviates
Язык: Английский
Процитировано
1
International Immunopharmacology, Год журнала: 2023, Номер 117, С. 109991 - 109991
Опубликована: Март 9, 2023
Язык: Английский
Процитировано
19
Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10271 - 10287
Опубликована: Май 7, 2024
Язык: Английский
Процитировано
7
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Окт. 4, 2023
Joint replacement surgery is the most effective treatment for end-stage arthritis. Aseptic loosening caused by periprosthetic osteolysis a common complication after joint replacement. Inflammation induced wear particles derived from prosthetic biomaterials major cause of osteolysis. We emphasize that bone marrow-derived macrophages and their fusion-derived osteoclasts play key role in this pathological process. Researchers have developed multiple intervention approaches to regulate macrophage/osteoclast activation. Aiming at particle-induced aseptic osteolysis, review separately discusses molecular mechanism regulation ROS formation inflammatory response through RANKL-MAPKs-NF-κB pathway. These mechanisms osteoclast activation different ways, but they are not isolated each other. There also lot crosstalk among mechanisms. In addition, other diseases related briefly introduced. Therefore, we discuss these new findings context existing work with view developing strategies particle-associated based on macrophages/osteoclasts.
Язык: Английский
Процитировано
16
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(26), С. 14727 - 14746
Опубликована: Июнь 22, 2024
: Following spinal cord injury (SCI), autophagy plays a positive role in neuronal protection, whereas pyroptosis triggers an inflammatory response. Ginsenoside-Rh2 (GRh2), known for its neuroprotective effects, is considered promising drug. However, the exact molecular mechanisms underlying these protective effects remain unclear.
Язык: Английский
Процитировано
4
Inflammopharmacology, Год журнала: 2024, Номер unknown
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
3
Metabolic Brain Disease, Год журнала: 2025, Номер 40(4)
Опубликована: Март 24, 2025
NOD-like receptor protein 3 (NLRP3)/cysteinyl aspartate-specific proteinase 1 (Caspase-1)/gasdermin D (GSDMD)-mediated pyroptosis is linked to spinal cord injury (SCI) pathogenesis. The levels of short-chain fatty acids (SCFAs), especially butyric acid, are significantly altered after SCI. Sodium butyrate (NaB) has anti-inflammatory effects on SCI; however, its effect unknown. aim this study was determine the role NaB in SCI functional recovery and NLRP3/Caspase-1/GSDMD-mediated pyroptosis. model rats were established using aneurysm clips. After SCI, administered (300 mg/kg) via gavage. SCFAs faeces measured gas chromatography-mass spectrometry. Motor function assessed cylinder rearing grooming tests. Histopathological analysis performed haematoxylin-eosin staining, transmission electron microscopy, terminal deoxynucleotidyl transferase dUTP nick-end labelling. expression proteins associated with signalling pathways analysed enzyme-linked immunosorbent assay, western blotting, immunohistochemistry. levels, particularly decreased treatment promoted forelimb motor attenuated pathological also pro-inflammatory factors (interleukin-18 interleukin-1β) downregulated pyroptosis-related proteins, including NLRP3, apoptosis-associated speck-like protein, Caspase-1, GSDMD. inhibits neuronal inflammation, exerting protective therapeutic suggesting as an effective treatment. (including acid) reduced improved inhibited inflammation.
Язык: Английский
Процитировано
0