Type, Duration, and Intensity of Physical Exercise Modulate FNDC5/Irisin Expression in the Hippocampus DOI Creative Commons
Upik Rahmi, Hanna Goenawan, Nova Sylviana

и другие.

Journal of Law and Sustainable Development, Год журнала: 2023, Номер 11(10), С. e1074 - e1074

Опубликована: Окт. 18, 2023

Introduction: Physical exercise can activate important biochemical processes in the human body, one of which is a myokine called irisin. Objective: This review aims to identify effect on expression FNDC5/irisin, secreted by skeletal muscles that produced response physical activity. hormone provides protective function central nervous system, specifically hippocampus. The effects brain are well known, but duration, intensity and type as underlying molecular mechanisms not fully understood. will focus Fibronectin III domain-containing protein 5 (FNDC5) its form, “irisin” with mechanism action hippocampus irisin expression. Method: A literature search was performed several databases (PubMed, Scopus, Sciencedirect) impact training irisin, resulting 17 articles. Results: shows increases plasma levels humans brains rats, including Discussion; relationship between exercise, FNDC5 (the gene encodes irisin), an area active research. FNDC5/irisin has gained attention for potential role mediating some beneficial brain, Conclusion: Irisin expressed result depends type, intensity, duration functions brain.

Язык: Английский

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression DOI Creative Commons
Ricardo A. S. Lima-Filho,

Juliana S. Fortuna,

Danielle Cozachenco

и другие.

eNeuro, Год журнала: 2023, Номер 10(2), С. ENEURO.0256 - 22.2023

Опубликована: Янв. 25, 2023

Major depressive disorder (MDD) is a major cause of disability in adults. MDD both comorbidity and risk factor for Alzheimer's disease (AD), regular physical exercise has been associated with reduced incidence severity AD. Irisin an exercise-induced myokine derived from proteolytic processing fibronectin type III domain-containing protein 5 (FNDC5). FNDC5/irisin the brains AD patients mouse models. However, whether brain expression altered depression remains elusive. Here, we investigate changes

Язык: Английский

Процитировано

19
Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease DOI Creative Commons
Eunhee Kim, Rudolph E. Tanzi, Se Hoon Choi

и другие.

Neural Regeneration Research, Год журнала: 2024, Номер 20(6), С. 1555 - 1564

Опубликована: Июль 10, 2024

Irisin is a myokine that generated by cleavage of the membrane protein fibronectin type III domain-containing 5 (FNDC5) in response to physical exercise. Studies reveal irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, most common form dementia elderly, improving cognitive function and reducing amyloid-β tau pathologies as well neuroinflammation cell culture or animal models disease. Although current ongoing studies on show promising results, further mechanistic are required clarify its potential meaningful therapeutic target for alleviating We recently found irisin treatment reduces pathology increasing activity/levels amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview irisin/FNDC5's protective roles mechanisms

Язык: Английский

Процитировано

5
The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis DOI Creative Commons
Robert R. Kraemer, Bradley R. Kraemer

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 24, 2023

Over the last decade, a considerable amount of new data have revealed beneficial effects exercise on hippocampal neurogenesis and maintenance or improvement cognitive function. Investigations with animal models, as well human studies, yielded novel understanding mechanisms through which endocrine signaling can stimulate neurogenesis, acute and/or chronic levels these circulating hormones. Considering aging decline specific factors that affect brain health, insights in this area research are particularly important. In review, we discuss how different forms influence peripheral production factors, particular emphasis brain-derived neurotrophic factor, growth hormone, insulin-like factor-1, ghrelin, estrogen, testosterone, irisin, vascular endothelial erythropoietin, cortisol. We also describe responses to induce cellular changes increase improve

Язык: Английский

Процитировано

11
Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy DOI Creative Commons
Cailin Wang, Xiufeng Wang,

Shangqi Sun

и другие.

Immunity & Ageing, Год журнала: 2024, Номер 21(1)

Опубликована: Май 14, 2024

Abstract Background The accumulation of senescent microglia has been highlighted as a critical contributor to the progression tauopathies. Irisin, muscle-derived hormone produced by proteolytic cleavage Fibronectin-domain III containing 5 (FNDC5), mediates pleiotropic effects exercise on physical body. Herein, we investigate potential role irisin in microglial senescence Methods To model tauopathies both vivo and vitro, utilized P301S tau transgenic mice K18 fibril-treated BV2 cells, respectively. We first examined expression phenotypes Subsequently, investigated impact its underlying molecular mechanisms. Result observed reduction levels an onset premature vitro. Irisin administration was found counteract ameliorate cognitive decline mice. Mechanistically, effectively inhibited stimulating mitochondrial transcription factor A (TFAM), master regulator respiratory chain biogenesis, thereby enhancing oxidative phosphorylation (OXPHOS). Silencing TFAM eliminated inhibitory effect well restorative OXPHOS. Furthermore, SIRT1/PGC1α signaling pathway appeared be implicated irisin-mediated upregulation TFAM. Conclusion Taken together, our study revealed that mitigated via TFAM-driven suggesting promising new avenue for therapeutic strategies targeting

Язык: Английский

Процитировано

4
Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice DOI Creative Commons
Felipe C. Ribeiro, Danielle Cozachenco, Luana Heimfarth

и другие.

Communications Biology, Год журнала: 2023, Номер 6(1)

Опубликована: Ноя. 7, 2023

Abstract The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, elimination of oxidized/misfolded proteins. Here, we investigate function localization at synapses Alzheimer’s disease (AD) post-mortem brain tissue experimental models. We found a marked increase ubiquitinylated proteins AD hippocampi compared to controls. Using several models, show that amyloid-β oligomers (AβOs) inhibit activity trigger reduction content. further inhibition specifically hippocampal fractions derived from APPswePS1ΔE9 mice. Reduced instigated AβOs is corrected treatment with rolipram, phosphodiesterase-4 inhibitor, Results dynein blocks AβO-induced dendritic content neurons. Finally, induces AD-like pathological features, including reactive oxygen species spine loss neurons, mRNA translation, impairment suggest may contribute deficits AD.

Язык: Английский

Процитировано

7
Association of the fibronectin type III domain–containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans DOI Creative Commons
Ricardo A. S. Lima-Filho, Andréa Lessa Benedet, Marco Antônio De Bastiani

и другие.

Brain Communications, Год журнала: 2023, Номер 5(4)

Опубликована: Янв. 1, 2023

Abstract Fibronectin type III domain–containing protein 5 (FNDC5) and its derived hormone, irisin, have been associated with metabolic control in humans, described FNDC5 single nucleotide polymorphisms being linked to obesity syndrome. Decreased brain FNDC5/irisin has reported subjects dementia due Alzheimer’s disease. Since impaired glucose metabolism develops ageing is prominent disease, here, we examined associations of a polymorphism the gene (rs1746661) amyloid-β deposition cohort 240 cognitively unimpaired 485 elderly individuals from Disease Neuroimaging Initiative. In harbouring rs1746661(T) allele, observed regional reduction low memory-linked regions increased PET load. No differences cognition or levels cerebrospinal fluid amyloid-β42, phosphorylated tau total were between allele carriers non-carriers. Our results indicate that genetic variant suggest may participate regulation vulnerable disease pathophysiology. Understanding variants metabolism-linked genes signatures contribute elucidating modulators humans.

Язык: Английский

Процитировано

5
Emerging concepts towards a translational framework in Alzheimer’s disease DOI
Danielle Cozachenco, Eduardo R. Zimmer, Mychael V. Lourenco

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 152, С. 105246 - 105246

Опубликована: Май 24, 2023

Язык: Английский

Процитировано

3
Contextual fear memory impairment in Angelman syndrome model mice is associated with altered transcriptional responses DOI Creative Commons

Wenyue Su,

Yan Liu, Aileen J. Lam

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Окт. 30, 2023

Abstract Angelman syndrome (AS) is a rare neurogenetic disorder caused by UBE3A deficiency and characterized severe developmental delay, cognitive impairment, motor dysfunction. In the present study, we performed RNA-seq on hippocampal samples from both wildtype (WT) AS male mice, with or without contextual fear memory recall. There were 281 recall-associated differentially expressed genes (DEGs) in WT mice 268 DEGs 129 shared two genotypes. Gene ontology analysis showed that extracellular matrix stimulation-induced response prominently enriched while nuclear acid metabolism tissue development highly those mice. Further analyses belonged to genes. Unique recall biological processes critical for synaptic plasticity learning memory, including network clustered around fibronectin 1 collagens. contrast, AS-specific not any known pathways. These results suggest altering transcriptome, fails recruit memory-associated transcriptional programs, which could be responsible impairment

Язык: Английский

Процитировано

2
Effects of Gestational Exercise on Nociception, BDNF, and Irisin Levels in an Animal Model of ADHD DOI

Andréa Tosta,

Ariene S. Fonseca,

Débora Messeder

и другие.

Neuroscience, Год журнала: 2024, Номер 543, С. 37 - 48

Опубликована: Фев. 22, 2024

Язык: Английский

Процитировано

0
Trolox and recombinant Irisin as a potential strategy to prevent neuronal damage induced by random positioning machine exposure in differentiated HT22 cells DOI Creative Commons
Roberto Bonanni, Ida Cariati, Anna Maria Rinaldi

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(3), С. e0300888 - e0300888

Опубликована: Март 21, 2024

Neuronal death could be responsible for the cognitive impairments found in astronauts exposed to spaceflight, highlighting need identify potential countermeasures ensure neuronal health microgravity conditions. Therefore, differentiated HT22 cells were simulated by random positioning machine (RPM) 48 h, treating them with a single administration of Trolox, recombinant irisin (r-Irisin) or both. Particularly, we investigated cell viability MTS assay, Trypan Blue staining and western blotting analysis Akt B-cell lymphoma 2 (Bcl-2), intracellular increase reactive oxygen species (ROS) fluorescent probe NADPH oxidase 4 (NOX4) expression, as well expression brain-derived neurotrophic factor (BDNF), major neurotrophin neurogenesis synaptic plasticity. Although both Trolox r-Irisin manifested protective effect on health, combined treatment produced best results, significant improvement all parameters examined. In conclusion, further studies are needed evaluate such combination counteracting weightlessness-induced death, other strategies safeguard spaceflight.

Язык: Английский

Процитировано

0