Recent advances in tissue repair of the blood-brain barrier after stroke

Journal of Tissue Engineering, Год журнала: 2024, Номер 15

Опубликована: Янв. 1, 2024

The selective permeability of the blood-brain barrier (BBB) enables necessary exchange substances between brain parenchyma and circulating blood is important for normal functioning central nervous system. Ischemic stroke inflicts damage upon BBB, triggering adverse outcomes such as cerebral edema, hemorrhagic transformation, aggravated neuroinflammation. Therefore, effective repair damaged BBB after neovascularization that allows unique transfer from recovery function. This review focuses on four therapies have effects tissue in last seven years. Most these new show increased expression tight-junction proteins, some beneficial results terms enhanced pericyte coverage at injured vessels. also briefly outlines three classes approaches their mechanisms promoting neoangiogenesis following a stroke.

Язык: Английский

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Crosstalk Among Glial Cells in the Blood–Brain Barrier Injury After Ischemic Stroke

Molecular Neurobiology, Год журнала: 2024, Номер 61(9), С. 6161 - 6174

Опубликована: Янв. 27, 2024

Язык: Английский

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Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes

Cells, Год журнала: 2024, Номер 13(11), С. 921 - 921

Опубликована: Май 27, 2024

The astrocyte population, around 50% of human brain cells, plays a crucial role in maintaining the overall health and functionality central nervous system (CNS). Astrocytes are vital orchestrating neuronal development by releasing synaptogenic molecules eliminating excessive synapses. They also modulate excitability contribute to CNS homeostasis, promoting survival clearance neurotransmitters, transporting metabolites, secreting trophic factors. highly heterogeneous respond injuries diseases through process known as reactive astrogliosis, which can both inflammation its resolution. Recent evidence has revealed remarkable alterations transcriptomes response several diseases, identifying at least two distinct phenotypes called A1 or neurotoxic A2 neuroprotective astrocytes. However, due vast heterogeneity these it is limited classify them into only phenotypes. This review explores various physiological pathophysiological roles, potential markers, pathways that might be activated different astrocytic Furthermore, we discuss main neurodegenerative identify therapeutic strategies. Understanding underlying mechanisms differentiation imbalance population will allow identification specific biomarkers timely approaches diseases.

Язык: Английский

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Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats

Journal of Ethnopharmacology, Год журнала: 2024, Номер 334, С. 118532 - 118532

Опубликована: Июль 6, 2024

Язык: Английский

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Extracellular cold-inducible RNA-binding protein in CNS injury: molecular insights and therapeutic approaches

Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)

Опубликована: Янв. 21, 2025

Abstract Central nervous system (CNS) injuries, such as ischemic stroke (IS), intracerebral hemorrhage (ICH) and traumatic brain injury (TBI), are a significant global burden. The complex pathophysiology of CNS is comprised primary secondary injury. Inflammatory incited by damage-associated molecular patterns (DAMPs) which signal variety resident cells infiltrating immune cells. Extracellular cold-inducible RNA-binding protein (eCIRP) DAMP acts through multiple non-immune to promote inflammation. Despite the well-established role eCIRP in systemic sterile inflammation, its less elucidated. Recent literature suggests that pleiotropic inflammatory mediator also being evaluated clinical biomarker indicate prognosis injuries. This review provides broad overview injury, with focus on immune-mediated neuroinflammation. We then what known about mechanisms both non-CNS cells, identifying opportunities for further study. explore eCIRP’s potential prognostic marker severity outcome. Next, we provide an eCIRP-targeting therapeutics suggest strategies develop these agents ameliorate Finally, emphasize exploring novel mechanisms, aside from neuroinflammation, critical therapeutic target

Язык: Английский

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Tetramethylpyrazine promotes axonal remodeling and modulates microglial polarization via JAK2-STAT1/3 and GSK3-NFκB pathways in ischemic stroke

Neurochemistry International, Год журнала: 2023, Номер 170, С. 105607 - 105607

Опубликована: Авг. 31, 2023

Ischemic stroke results in demyelination that underlies neurological disfunction. Promoting oligodendrogenesis will rescue the injured axons and accelerate remyelination after stroke. Microglia react to ischemia/hypoxia polarize M1/M2 phenotypes influencing myelin injury repair. Tetramethylpyrazine (TMP) has neuroprotective effects treating cerebrovascular disorders. This study aims evaluate whether TMP promotes renovation of damaged brain tissues especially on modulates microglia following ischemic Here magnetic resonance imaging (MRI)-diffusion tensor (DTI) histopathological evaluation are performed characterize process remyelination. Immunofluorescence staining is used prove microglial polarization. Western blotting conducted examine interleukin (IL)-6, IL-10, transforming growth factor β (TGF-β) Janus protein tyrosine kinase (JAK) 2-signal transducer activator transcription (STAT) 1/3-glycogen synthase (GSK) 3-nuclear κB (NFκB) signals. Results show alleviates sheath, increases NG2+, Ki67+/NG2+, CNPase+, Ki67+/CNPase+, Iba1+/Arg-1+ cells decreases Iba1+ Iba1+/CD16+ periinfarctions rats. Particularly, downregulates IL-6 upregulates IL-10 TGF-β expressions, besides, enhances JAK2-STAT3 suppresses STAT1-GSK3-NFκB activation middle cerebral artery occlusion (MCAo) Then we demonstrate reverses phenotype via JAK2-STAT1/3 GSK3-NFκB pathways lipopolysaccharide (LPS) plus interferon-γ (IFN-γ)-stimulated BV2 microglia. Blocking JAK2 with AG490 counteracts TMP's facilitation M2 polarization warrants promising therapy for treatment.

Язык: Английский

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Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 1499 - 1514

Опубликована: Май 1, 2024

Ferroptosis plays a crucial role in the occurrence and development of cerebral ischemia-reperfusion (I/R) injury is regulated by mitogen-activated protein kinase 1/2 (ERK1/2). In China, Naodesheng Pills (NDSP) are prescribed to prevent treat cerebrosclerosis stroke. However, protective effects mechanism action NDSP against I/R-induced ferroptosis remain unclear. We investigated whether exerts its I/R regulating aimed elucidate underlying mechanisms.

Язык: Английский

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Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood–spinal cord barrier and neurons

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(18), С. 4409 - 4426

Опубликована: Янв. 1, 2024

The tetramethylpyrazine-loaded conductive hydrogel could diminish the breakdown of blood–spinal cord barrier and protect against neuronal cell death to synergistically restore neurological functions post spinal injury.

Язык: Английский

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Metabolic reprogramming and astrocytes polarization following ischemic stroke

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Distinct roles of A1/A2 astrocytes in blood-brain barrier injury following cerebral I/R via the ROCK/NF-κB and STAT3 pathways

International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114338 - 114338

Опубликована: Фев. 27, 2025

Язык: Английский

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