Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 1, 2025
The
dried
rhizome
of
Ligusticum
chuanxiong
S.H.Qiu,
Y.Q.Zeng,
K.Y.Pan,
Y.C.Tang
and
J.M.Xu
(Apiaceae;
including
the
horticultural
variety
Hort.)
[synonym:
Conioselinum
anthriscoides
(H.Boissieu)
Pimenov
Kljuykov
(The
taxonomic
classification
has
been
adopted
by
World
Checklist
Vascular
Plants)]
is
a
traditional
Chinese
botanical
drug
renowned
for
its
anti-inflammatory
antioxidant
properties.
It
widely
used
to
treatment
various
diseases,
particularly
cardio-cerebral
vascular
diseases
(CCVDs).
This
review
aims
summarize
recent
advances
in
(CX)
research,
chemical
composition
pharmacological
effects,
modern
clinical
applications.
A
systematic
literature
search
was
conducted
using
keywords
such
as
"Chuanxiong,"
"traditional
medicine,"
"chemical
components,"
"metabolites,"
"CCVDs,"
"pharmacological
effects"
identify
relevant
published
between
2014
2025.
Databases
PubMed,
Web
Science,
Google
Scholar,
CNKI
were
utilized.
Chemical
structures
SMILES
format
retrieved
from
PubChem,
two-dimensional
generated
ChemDraw
Ultra
8.0.
Classical
prescriptions
obtained
authoritative
medicine
databases.
Over
100
metabolites
have
isolated
identified
CX,
classified
into
nine
major
classes.
Key
bioactive
compounds
include
senkyunolide
A,
ligustilide,
tetramethylpyrazine
(TMP),
ligusticum
CX
polysaccharides
(LCP).
demonstrates
significant
effects
treating
CCVDs,
atherosclerosis
(AS),
myocardial
cerebral
ischemia-reperfusion
injury,
hypertension.
Its
therapeutic
mechanisms
antiplatelet
activity,
endothelial
cell
protection,
anti-inflammatory,
antioxidant,
anti-apoptotic
can
be
administered
alone
or
combination
with
other
medicines
(TCMs)
drugs,
showing
efficacy
cardiovascular,
nervous
system,
digestive
system
disorders,
well
analgesia
anticancer
activities.
holds
substantial
value
multi-system
extensive
evidence
supporting
use
CCVDs.
Further
research
exploration
are
warranted
fully
harness
potential.
Journal of Tissue Engineering,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 1, 2024
The
selective
permeability
of
the
blood-brain
barrier
(BBB)
enables
necessary
exchange
substances
between
brain
parenchyma
and
circulating
blood
is
important
for
normal
functioning
central
nervous
system.
Ischemic
stroke
inflicts
damage
upon
BBB,
triggering
adverse
outcomes
such
as
cerebral
edema,
hemorrhagic
transformation,
aggravated
neuroinflammation.
Therefore,
effective
repair
damaged
BBB
after
neovascularization
that
allows
unique
transfer
from
recovery
function.
This
review
focuses
on
four
therapies
have
effects
tissue
in
last
seven
years.
Most
these
new
show
increased
expression
tight-junction
proteins,
some
beneficial
results
terms
enhanced
pericyte
coverage
at
injured
vessels.
also
briefly
outlines
three
classes
approaches
their
mechanisms
promoting
neoangiogenesis
following
a
stroke.
Cells,
Год журнала:
2024,
Номер
13(11), С. 921 - 921
Опубликована: Май 27, 2024
The
astrocyte
population,
around
50%
of
human
brain
cells,
plays
a
crucial
role
in
maintaining
the
overall
health
and
functionality
central
nervous
system
(CNS).
Astrocytes
are
vital
orchestrating
neuronal
development
by
releasing
synaptogenic
molecules
eliminating
excessive
synapses.
They
also
modulate
excitability
contribute
to
CNS
homeostasis,
promoting
survival
clearance
neurotransmitters,
transporting
metabolites,
secreting
trophic
factors.
highly
heterogeneous
respond
injuries
diseases
through
process
known
as
reactive
astrogliosis,
which
can
both
inflammation
its
resolution.
Recent
evidence
has
revealed
remarkable
alterations
transcriptomes
response
several
diseases,
identifying
at
least
two
distinct
phenotypes
called
A1
or
neurotoxic
A2
neuroprotective
astrocytes.
However,
due
vast
heterogeneity
these
it
is
limited
classify
them
into
only
phenotypes.
This
review
explores
various
physiological
pathophysiological
roles,
potential
markers,
pathways
that
might
be
activated
different
astrocytic
Furthermore,
we
discuss
main
neurodegenerative
identify
therapeutic
strategies.
Understanding
underlying
mechanisms
differentiation
imbalance
population
will
allow
identification
specific
biomarkers
timely
approaches
diseases.
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Янв. 21, 2025
Abstract
Central
nervous
system
(CNS)
injuries,
such
as
ischemic
stroke
(IS),
intracerebral
hemorrhage
(ICH)
and
traumatic
brain
injury
(TBI),
are
a
significant
global
burden.
The
complex
pathophysiology
of
CNS
is
comprised
primary
secondary
injury.
Inflammatory
incited
by
damage-associated
molecular
patterns
(DAMPs)
which
signal
variety
resident
cells
infiltrating
immune
cells.
Extracellular
cold-inducible
RNA-binding
protein
(eCIRP)
DAMP
acts
through
multiple
non-immune
to
promote
inflammation.
Despite
the
well-established
role
eCIRP
in
systemic
sterile
inflammation,
its
less
elucidated.
Recent
literature
suggests
that
pleiotropic
inflammatory
mediator
also
being
evaluated
clinical
biomarker
indicate
prognosis
injuries.
This
review
provides
broad
overview
injury,
with
focus
on
immune-mediated
neuroinflammation.
We
then
what
known
about
mechanisms
both
non-CNS
cells,
identifying
opportunities
for
further
study.
explore
eCIRP’s
potential
prognostic
marker
severity
outcome.
Next,
we
provide
an
eCIRP-targeting
therapeutics
suggest
strategies
develop
these
agents
ameliorate
Finally,
emphasize
exploring
novel
mechanisms,
aside
from
neuroinflammation,
critical
therapeutic
target
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 1499 - 1514
Опубликована: Май 1, 2024
Ferroptosis
plays
a
crucial
role
in
the
occurrence
and
development
of
cerebral
ischemia-reperfusion
(I/R)
injury
is
regulated
by
mitogen-activated
protein
kinase
1/2
(ERK1/2).
In
China,
Naodesheng
Pills
(NDSP)
are
prescribed
to
prevent
treat
cerebrosclerosis
stroke.
However,
protective
effects
mechanism
action
NDSP
against
I/R-induced
ferroptosis
remain
unclear.
We
investigated
whether
exerts
its
I/R
regulating
aimed
elucidate
underlying
mechanisms.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(18), С. 4409 - 4426
Опубликована: Янв. 1, 2024
The
tetramethylpyrazine-loaded
conductive
hydrogel
could
diminish
the
breakdown
of
blood–spinal
cord
barrier
and
protect
against
neuronal
cell
death
to
synergistically
restore
neurological
functions
post
spinal
injury.
