Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats

Journal of Ethnopharmacology, Год журнала: 2024, Номер 334, С. 118532 - 118532

Опубликована: Июль 6, 2024

Язык: Английский

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Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1509 - 1528

Опубликована: Фев. 1, 2025

Abstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in progression of inflammatory diseases. Mitochondria, often referred as "power plants" cell, are essential organelles responsible critical functions such energy metabolism, material synthesis, signal transduction. functional state mitochondria closely linked macrophage polarization, prompting interest strategies that target regulate this process. To end, biomaterials with excellent targeting capabilities effective properties have been developed influence mitochondrial function polarization. However, comprehensive summary biomaterial-driven modulation control phenotypes still lacking. This review highlights polarization discusses mediated by biomaterials, including mitochondria-targeted biomaterials. Finally, prospects challenges use these explored, emphasizing their potential be translated clinic. It anticipated will serve valuable resource materials scientists clinicians development next-generation Keywords: macrophages,

Язык: Английский

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Buyang Huanwu decoction promotes gray and white matter remyelination by inhibiting Notch signaling activation in the astrocyte and microglia after ischemic stroke

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119440 - 119440

Опубликована: Фев. 1, 2025

Язык: Английский

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Microglia and Stem Cells for Ischemic Stroke Treatment—Mechanisms, Current Status, and Therapeutic Challenges

Frontiers in Bioscience-Landmark, Год журнала: 2023, Номер 28(10)

Опубликована: Окт. 27, 2023

Ischemic stroke is one of the major causes death and disability. Since currently used treatment option reperfusion therapy has several limitations, ongoing research focusing on neuroprotective effects microglia stem cells. By exerting bystander effect, secreting exosomes forming biobridges, mesenchymal cells (MSCs), neural (NSCs), induced pluripotent (iPSCs), multilineage-differentiating stress-enduring (Muse cells) have been shown to stimulate neurogenesis, angiogenesis, cell migration, reduce neuroinflammation. Exosome-based now being extensively researched due its many advantageous properties over therapy, such as lower immunogenicity, no risk blood vessel occlusion, ease storage modification. However, although preclinical studies promising therapeutic outcomes, clinical trials associated with translational challenges. This review explores preconditioned well various factors secreted in cell-derived extracellular vesicles their mechanisms action explained. Furthermore, an overview presented, explaining main challenges therapies, providing potential solutions. In particular, a highlight use novel Muse cells, which bypasses conventional limitations. The paper concludes suggestions for directions future research.

Язык: Английский

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Remote Ischemic Post-conditioning Reduces Cognitive Impairment in Rats Following Subarachnoid Hemorrhage: Possible Involvement in STAT3/STAT5 Phosphorylation and Th17/Treg Cell Homeostasis

Translational Stroke Research, Год журнала: 2024, Номер unknown

Опубликована: Фев. 15, 2024

Язык: Английский

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NDUFA11 may be the disulfidptosis-related biomarker of ischemic stroke based on integrated bioinformatics, clinical samples, and experimental analyses

Frontiers in Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 14, 2025

Background Programmed cell death plays an important role in neuronal injury and after ischemic stroke (IS), leading to cellular glucose deficiency. Glucose deficiency can cause abnormal accumulation of cytotoxic disulfides, resulting disulfidptosis. Ferroptosis, apoptosis, necroptosis, autophagy inhibitors cannot inhibit this novel programmed mechanism. Nevertheless, the potential mechanisms disulfidptosis IS remain unclear. Methods The GSE16561 dataset was used screen for differentially expressed disulfidptosis-related biomarkers (DE-DRBs). A correlation between DE-DRBs detected. optimal machine-learning (ML) model predictor molecules were determined. GSE58294 verify accuracy ML model. DE-DRB expression detected blood patients with IS. Based on models, experimental analyses performed DE-DRBs. Results Leucine-rich pentatricopeptide repeat-containing (LRPPRC) NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (NDUFA11) identified as NADH: ubiquinone oxidoreductase core S1 (NDUFS1) interacted NDUFA11 LRPPRC. support vector machine (SVM) level 20.9% compared that normal controls. downregulated vitro/in vivo models number formed complexes NDUFS1 decreased Conclusion This research suggests is a specific DRB demonstrates alterations protein NDUFS1-NDUFA11.

Язык: Английский

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Investigating the Potential Therapeutic Targeting of the JAK-STAT Pathway in Cerebrovascular Diseases: Opportunities and Challenges

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

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Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis

Antioxidants, Год журнала: 2025, Номер 14(3), С. 363 - 363

Опубликована: Март 19, 2025

The disruption of microglial homeostasis and cytokine release are critical for neuroinflammation post-injury strongly implicated in retinal neurodegenerative diseases like glaucoma. This study examines responses to chemical hypoxia induced by cobalt chloride (CoCl2) BV-2 murine cells, focusing on signaling pathways proteomic alterations. We assessed the protective effects monoclonal antibodies against TNFα IL-1β. CoCl2 exposure led decreased cell viability, reduced mitochondrial membrane potential, increased lactate dehydrogenase release, elevated reactive oxygen species generation, activation inflammatory pathways, including nitric oxide synthase (iNOS), STAT1, NF-κB/NLRP3. These were significantly mitigated treatment with anti-TNFα anti-IL-1β, suggesting their dual role reducing damage inhibiting reactivity. Additionally, these treatments apoptosis modulating ATF4 p38 MAPK/caspase-3 pathways. Label-free quantitative mass spectrometry-based proteomics Gene Ontology revealed that upregulation proteins primarily involved endoplasmic reticulum catabolic processes, while downregulated associated biosynthesis. Anti-TNFα anti-IL-1β partially restored profile toward normalcy, network analysis identifying heat shock protein family A member 8 (HSPA8) as a central mediator recovery. findings offer insights into pathogenesis hypoxic impairment suggest potential therapeutic targets.

Язык: Английский

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Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredient-based selenium nanoparticles for treating spinal cord injury

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101758 - 101758

Опубликована: Апрель 1, 2025

Язык: Английский

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Buyang Huanwu decoction improves motor function by enhancing internal capsule reorganization through inhibiting Notch signaling after ischemic stroke

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119812 - 119812

Опубликована: Апрель 1, 2025

Язык: Английский

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