Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(47)

Опубликована: Ноя. 12, 2024

The role of transcription factors in photoreceptor gene regulation is fairly well understood, but knowledge the cell-type-specific function transcriptional cofactors remains incomplete. Here, we show that corepressor samd7 promotes rod differentiation and represses short-wavelength cone genes long-wavelength cones zebrafish. In −/− retinas, red are transformed into hybrid red/ultraviolet (UV) cones, green absent, number blue approximately doubled, rods greatly reduced. We also find mouse Samd7 S-opsin expression dorsal M-cones—analogous to its repressing UV zebrafish cones. Thus, plays a key ensuring appropriate patterns subtypes both mice.

Язык: Английский

Plasticity of cone photoreceptors in adult zebrafish revealed by thyroid hormone exposure

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 21, 2023

Vertebrate color vision is predominantly mediated by the presence of multiple cone photoreceptor subtypes that are each maximally sensitive to different wavelengths light. Thyroid hormone (TH) has been shown be essential in spatiotemporal patterning many species, including express opsins encoded tandemly replicated genes. TH differentially regulate lws opsin genes zebrafish, and exogenous treatments alter expression levels these larvae juveniles. In this study, we sought determine whether gene photoreceptors remains plastic treatment adults. We used a transgenic reporter line, multiplexed fluorescence hybridization chain reaction situ hybridization, qPCR examine extent which can altered Our studies revealed expression, other genes, adult zebrafish. addition retinal plasticity, alters skin pigmentation patterns zebrafish after 5 days. Taken together, our results show remarkable level TH-sensitive plasticity

Язык: Английский