Innovative Strategies in 3D Bioprinting for Spinal Cord Injury Repair

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9592 - 9592

Опубликована: Сен. 4, 2024

Spinal cord injury (SCI) is a catastrophic condition that disrupts neurons within the spinal cord, leading to severe motor and sensory deficits. While current treatments can alleviate pain, they do not promote neural regeneration or functional recovery. Three-dimensional (3D) bioprinting offers promising solutions for SCI repair by enabling creation of complex tissue constructs. This review provides comprehensive overview 3D techniques, bioinks, stem cell applications in repair. Additionally, it highlights recent advancements bioprinted scaffolds, including integration conductive materials, incorporation bioactive molecules like neurotrophic factors, drugs, exosomes, design innovative structures such as multi-channel axial scaffolds. These strategies offer approach optimizing microenvironment, advancing understanding state repair, offering insights into future directions field regenerative medicine.

Язык: Английский

Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 23, 2025

Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.

Язык: Английский

Current multi-scale biomaterials for tissue regeneration following spinal cord injury

Neurochemistry International, Год журнала: 2024, Номер 178, С. 105801 - 105801

Опубликована: Июль 5, 2024

Язык: Английский