Cerebellar Roles in Motor and Social Functions and Implications for ASD
The Cerebellum,
Год журнала:
2024,
Номер
23(6), С. 2564 - 2574
Опубликована: Июль 17, 2024
Язык: Английский
Alpha6-containing GABAA receptors – Novel targets for the treatment of schizophrenia
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107613 - 107613
Опубликована: Янв. 1, 2025
Язык: Английский
A HIDDEN MARK OF A TROUBLED PAST: NEUROIMAGING AND TRANSCRIPTOMIC ANALYSES REVEAL INTERACTIVE EFFECTS OF MATERNAL IMMUNE ACTIVATION AND ADOLESCENT THC EXPOSURE SUGGESTIVE OF INCREASED NEUROPSYCHIATRIC RISK
Biological Psychiatry Global Open Science,
Год журнала:
2025,
Номер
5(3), С. 100452 - 100452
Опубликована: Янв. 23, 2025
Maternal
exposure
to
infections
during
gestation
has
been
shown
predispose
individuals
neuropsychiatric
disorders.
Additionally,
clinical
data
suggest
that
cannabis
use
may
trigger
the
onset
of
schizophrenia
in
vulnerable
individuals.
However,
direction
causality
remains
unclear.
To
elucidate
this
issue,
we
utilized
a
rat
model
maternal
immune
activation
combined
with
increasing
doses
Δ9-tetrahydrocannabinol
adolescence
both
male
and
female
rats.
We
investigated
several
behaviors
adulthood
relevant
for
disorders,
including
impairments
working
memory,
deficits
sensorimotor
gating,
alterations
social
behavior,
anhedonia,
potential
changes
implicit
learning
(conditioned
taste
aversion).
Furthermore,
conducted
longitudinal
positron
emission
tomography
study
target
affected
brain
regions
and,
subsequently,
collected
samples
one
such
region
(the
orbitofrontal
cortex)
RNA
sequencing
analyses,
which
were
also
performed
on
peripheral
blood
mononuclear
cells
identify
biomarkers.
While
adolescent
did
not
unmask
latent
behavioral
disruptions,
scans
revealed
dependent
combination
hits.
transcriptomic
studies
demonstrated
dopaminergic,
glutamatergic,
serotoninergic
genes,
exposures
most
cases
shifting
expression
from
downregulation
upregulation.
In
cells,
interactive
effects
observed
inflammatory
pathways,
some
genes
proposed
as
These
results
these
2
vulnerability
factors
leaves
lasting
mark
body,
potentially
predisposing
disorders
even
before
manifest.
Язык: Английский
The Cerebellar Neuropsychiatric Rating Scale: A New Card in the Deck
The Cerebellum,
Год журнала:
2025,
Номер
24(2)
Опубликована: Март 4, 2025
Язык: Английский
Adaptive Constrained ICA with Mixing Matrix Column Constraints: Application to fMRI Data
Опубликована: Март 19, 2025
Язык: Английский
Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies
Ageing Research Reviews,
Год журнала:
2024,
Номер
unknown, С. 102519 - 102519
Опубликована: Сен. 1, 2024
Язык: Английский
Cerebellar Theta Burst Stimulation Impairs Working Memory
The Cerebellum,
Год журнала:
2024,
Номер
23(6), С. 2324 - 2331
Опубликована: Авг. 22, 2024
Язык: Английский
Comparison of Two Normalization Structures in Brain Perfusion Tomography in the First Episode of Schizophrenia Using Commercial Software
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 15, 2024
Abstract
Objectives:
Single
photon
emission
computed
tomography
with
Tc-99m
hexamethylpropylenamine
oxime
provides
information
on
brain
perfusion
distribution
in
psychiatric
patients.
The
assessment
of
cerebral
blood
flow
using
different
normalization
structures
could
be
diverse.
Methods:
Quantification
programs
may
improve
diagnosis,
but
adequate
structure
must
selected.
We
compared
regional
twelve
regions
associated
schizophrenia
two
-
whole
and
cerebellum
antipsychotic
drug-
naive
patients
during
the
first
episode
schizophrenia.
Results:
analyzed
12
50
Z-scores
for
each
entire
region,
as
well
left
right
Z-scores,
were
calculated
based
an
age-matched
normal
database.
chose
Z-score
calculation,
cerebellum.
Conclusion:
Based
results,
we
conclude
that
both
can
used.
However,
highest
matches
observed
gyrus
rectus,
orbitofrontal
inferior
medial
frontal
gyrus,
orbital
middle
anterior
cingulate
superior
caudate,
while
lowest
found
temporal
region
thalamus.
Язык: Английский
Cognitive rehabilitation in schizophrenia research: a bibliometric and visualization analysis
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 11, 2024
Objective
Cognitive
impairment
is
notably
prevalent
among
schizophrenic
individuals
and
acknowledged
as
one
of
the
core
features
disorder.
Despite
proliferation
literature
on
cognitive
rehabilitation
treatments
for
schizophrenia
in
recent
years,
there
remains
a
dearth
systematic
reviews
selections
research
this
area.
From
bibliometric
perspective,
study
aims
to
analyze
discuss
current
state,
developmental
trends,
potential
hotspots
over
past
two
decades.
Methods
The
Core
database
Web
Science
was
utilized
retrieve
articles
Schizophrenia
that
were
published
from
2004
2024.
Bibliometrics
applied
perform
both
quantitative
qualitative
analyses
authors,
institutions,
countries,
journals,
references,
keywords,
leveraging
tools
such
CiteSpace,
VOSviewer,
R
software
package
Bibliometrix.
Results
A
total
2,413
encompassed
study,
comprising
1,774
regular
373
review
articles.
United
States
emerged
country
with
highest
productivity
citation
counts,
engaging
academic
collaborations
40
nations.
This
followed
by
Kingdom
Spain.
King’s
College
London
stood
out
leading
institution
field.
However,
article
average
rate
authored
Susan
R.
McGurk
Dartmouth
Centre
Psychiatric
Research
States.
proved
be
most
influential
journal
domain,
its
being
cited
10,000
times.
Conclusion
provides
comprehensive
achievements
spanning
2024,
outlines
global
trends
future
projections.
Currently,
methods
neural
plasticity
brain
represent
cutting-edge
research.
safety,
efficacy,
standardization
virtual
reality
are
poised
emerge
Additionally,
neurobiological
foundations
remediation
therapy
constitute
an
unexplored
territory
ripe
further
investigation.
Язык: Английский