Comparison of Two Normalization Structures in Brain Perfusion Tomography in the First Episode of Schizophrenia Using Commercial Software DOI Creative Commons
Ines Šiško Markoš,

Ivan Blažeković,

Ivona Orlović

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Objectives: Single photon emission computed tomography with Tc-99m hexamethylpropylenamine oxime provides information on brain perfusion distribution in psychiatric patients. The assessment of cerebral blood flow using different normalization structures could be diverse. Methods: Quantification programs may improve diagnosis, but adequate structure must selected. We compared regional twelve regions associated schizophrenia two - whole and cerebellum antipsychotic drug- naive patients during the first episode schizophrenia. Results: analyzed 12 50 Z-scores for each entire region, as well left right Z-scores, were calculated based an age-matched normal database. chose Z-score calculation, cerebellum. Conclusion: Based results, we conclude that both can used. However, highest matches observed gyrus rectus, orbitofrontal inferior medial frontal gyrus, orbital middle anterior cingulate superior caudate, while lowest found temporal region thalamus.

Language: Английский

Alpha6-containing GABAA receptors – Novel targets for the treatment of schizophrenia DOI Creative Commons
Lih‐Chu Chiou, Werner Sieghart

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107613 - 107613

Published: Jan. 1, 2025

Language: Английский

Citations

1
Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies DOI
Azhagu Madhavan Sivalingam

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102519 - 102519

Published: Sept. 1, 2024

Language: Английский

Citations

5
Cerebellar Roles in Motor and Social Functions and Implications for ASD DOI
Azhagu Madhavan Sivalingam, Arjun Pandian

The Cerebellum, Journal Year: 2024, Volume and Issue: 23(6), P. 2564 - 2574

Published: July 17, 2024

Language: Английский

Citations

4
A HIDDEN MARK OF A TROUBLED PAST: NEUROIMAGING AND TRANSCRIPTOMIC ANALYSES REVEAL INTERACTIVE EFFECTS OF MATERNAL IMMUNE ACTIVATION AND ADOLESCENT THC EXPOSURE SUGGESTIVE OF INCREASED NEUROPSYCHIATRIC RISK DOI Creative Commons
Mario G. Moreno, Víctor Luján, Shishir Baliyan

et al.

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: 5(3), P. 100452 - 100452

Published: Jan. 23, 2025

Maternal exposure to infections during gestation has been shown predispose individuals neuropsychiatric disorders. Additionally, clinical data suggest that cannabis use may trigger the onset of schizophrenia in vulnerable individuals. However, direction causality remains unclear. To elucidate this issue, we utilized a rat model maternal immune activation combined with increasing doses Δ9-tetrahydrocannabinol adolescence both male and female rats. We investigated several behaviors adulthood relevant for disorders, including impairments working memory, deficits sensorimotor gating, alterations social behavior, anhedonia, potential changes implicit learning (conditioned taste aversion). Furthermore, conducted longitudinal positron emission tomography study target affected brain regions and, subsequently, collected samples one such region (the orbitofrontal cortex) RNA sequencing analyses, which were also performed on peripheral blood mononuclear cells identify biomarkers. While adolescent did not unmask latent behavioral disruptions, scans revealed dependent combination hits. transcriptomic studies demonstrated dopaminergic, glutamatergic, serotoninergic genes, exposures most cases shifting expression from downregulation upregulation. In cells, interactive effects observed inflammatory pathways, some genes proposed as These results these 2 vulnerability factors leaves lasting mark body, potentially predisposing disorders even before manifest.

Language: Английский

Citations

0
The Cerebellar Neuropsychiatric Rating Scale: A New Card in the Deck DOI Creative Commons

Stefan Fritze,

Roberta Ferrucci, Mario Manto

et al.

The Cerebellum, Journal Year: 2025, Volume and Issue: 24(2)

Published: March 4, 2025

Language: Английский

Citations

0
Adaptive Constrained ICA with Mixing Matrix Column Constraints: Application to fMRI Data DOI
Chunying Jia, Weixin Wang, Trung Vu

et al.

Published: March 19, 2025

Language: Английский

Citations

0
Linking cellular-level phenomena to brain architecture: the case of spiking cerebellar controllers DOI Creative Commons
Egidio D’Angelo, Alberto Antonietti, Alice Geminiani

et al.

Neural Networks, Journal Year: 2025, Volume and Issue: 188, P. 107538 - 107538

Published: April 23, 2025

Linking cellular-level phenomena to brain architecture and behavior is a holy grail for theoretical computational neuroscience. Advances in neuroinformatics have recently allowed scientists embed spiking neural networks of the cerebellum with realistic neuron models multiple synaptic plasticity rules into sensorimotor controllers. By minimizing distance (error) between desired actual sensory state, exploiting prediction, cerebellar network acquires knowledge about body-environment interaction generates corrective signals. In doing so, implements generalized algorithm, allowing it "to learn predict timing correlated events" rich set behavioral contexts. Plastic changes evolve trial by are distributed over synapses, regulating neuronal discharge fine-tuning high-speed movements on millisecond timescale. Thus, built-in controllers, among various approaches studying function, helping reveal substrates learning signal coding, opening new frontiers predictive computing autonomous robots.

Language: Английский

Citations

0
New Perspectives on Non-Invasive Cerebellar Stimulation for Social and Affective Functions in Children and Adolescents DOI Creative Commons
Ludovica Pasca, Romina Romaniello, Renato Borgatti

et al.

The Cerebellum, Journal Year: 2025, Volume and Issue: 24(4)

Published: April 26, 2025

Cerebellar dysfunction affects socio-affective abilities beyond motor control. Recent studies suggest that non-invasive cerebellar neurostimulation can modulate social cognition networks, offering potential therapeutic benefits for children with autism, ADHD, and mood disorders. However, its application in pediatrics remains largely unexplored. This review summarizes emerging pediatric research on transcranial magnetic stimulation (TMS) direct current (tDCS). We discuss their mechanisms, benefits, safety considerations, highlighting preliminary findings feasibility effectiveness. Ethical concerns technical challenges related to neuroanatomy parameters are also addressed. While early results promising, further clinical trials neurophysiological essential optimize protocols confirm long-term efficacy. Advancing our understanding of involvement functions could lead innovative rehabilitation strategies neurodevelopmental

Language: Английский

Citations

0
Integrating Proteomics and GWAS to Identify Key Tissues and Genes Underlying Human Complex Diseases DOI Creative Commons
Chao Xue, Miao Zhou

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 554 - 554

Published: May 16, 2025

The tissues of origin and molecular mechanisms underlying human complex diseases remain incompletely understood. Previous studies have leveraged transcriptomic data to interpret genome-wide association (GWASs) for identifying disease-relevant fine-mapping causal genes. However, according the central dogma, proteins more directly reflect cellular activities than RNA. Therefore, in this study, we integrated proteomic with GWAS identify disease-associated We compiled paired 12,229 genes across 32 from GTEx project. Using three tissue inference approaches-S-LDSC, MAGMA, DESE-we analyzed six representative (bipolar disorder, schizophrenia, coronary artery disease, Crohn's rheumatoid arthritis, type 2 diabetes), an average sample size 260 K. systematically compared identified using versus data. Tissue-specific protein abundance showed a moderate correlation RNA expression (mean coefficient = 0.46, 95% CI: 0.42-0.49). Proteomic accurately tissues, such as between brain regions schizophrenia arteries disease. Compared GWAS-based gene estimates alone, incorporating significantly improved detection (AUC difference test, p 0.0028). Furthermore, revealed unique that were not data, bipolar disorder CREB1. Integrating enables accurate identification provides irreplaceable advantages diseases.

Language: Английский

Citations

0
Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice DOI Open Access
Sarah G Donofrio, Cheryl Brandenburg, Amanda M. Brown

et al.

Published: May 21, 2025

Abstract Age-related neurodegenerative diseases involve reduced cell numbers and impaired behavioral capacity. Neurodegeneration deficits also occur during aging, notably in the absence of disease. The cerebellum, which modulates movement cognition, is susceptible to loss both aging Here, we demonstrate that cerebellar Purkinje aged mice not spatially random but rather occurs a pattern parasagittal stripes. We find exhibit motor coordination more severe tremor compared younger mice. However, relationship between patterned dysfunction straightforward. Examination postmortem samples human cerebella from neurologically typical individuals supports presence selective cells aging. These data reveal spatiotemporal cellular substrate for cerebellum may inform about how neuronal vulnerability leads neurodegeneration ensuing deterioration behavior.

Language: Английский

Citations

0