Frontiers in Human Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Дек. 4, 2024
Low-intensity
transcranial
focused
ultrasound
(tFUS)
is
a
brain
stimulation
approach
that
holds
promise
for
the
treatment
of
brain-based
disorders.
Studies
in
humans
have
shown
tFUS
can
successfully
modulate
perfusion
focal
sonication
targets,
including
amygdala;
however,
limited
research
has
explored
how
impacts
large-scale
neural
networks.
Neurotherapeutics,
Год журнала:
2024,
Номер
21(3), С. e00330 - e00330
Опубликована: Фев. 9, 2024
Over
the
past
30
years,
field
of
neuromodulation
has
witnessed
remarkable
advancements.
These
developments
encompass
a
spectrum
techniques,
both
non-invasive
and
invasive,
that
possess
ability
to
probe
influence
central
nervous
system.
In
many
cases
therapies
have
been
adopted
into
standard
care
treatments.
Transcranial
magnetic
stimulation
(TMS),
transcranial
direct
current
(tDCS),
ultrasound
(TUS)
are
most
common
methods
in
use
today.
Deep
brain
(DBS),
spinal
cord
(SCS),
vagus
nerve
(VNS),
leading
surgical
for
neuromodulation.
Ongoing
active
clinical
trials
using
uncovering
novel
applications
paradigms
these
interventions.
Brain stimulation,
Год журнала:
2024,
Номер
17(2), С. 312 - 320
Опубликована: Март 1, 2024
BackgroundCurrent
noninvasive
brain
stimulation
methods
are
incapable
of
directly
modulating
subcortical
regions
critically
involved
in
psychiatric
disorders.
Transcranial
Focused
Ultrasound
(tFUS)
is
a
newer
form
that
could
modulate
the
amygdala,
region
implicated
fear.ObjectiveWe
investigated
effects
active
and
sham
tFUS
amygdala
on
fear
circuit
activation,
skin
conductance
responses
(SCR),
self-reported
anxiety
during
fear-inducing
task.
We
also
tFUS'
amygdala-fear
resting-state
functional
connectivity.MethodsThirty
healthy
individuals
were
randomized
this
double-blinded
study
to
or
left
amygdala.
collected
fMRI
scans,
SCR,
task
(participants
viewed
red
green
circles
which
indicated
risk
receiving
an
aversive
stimulus),
as
well
before
after
tFUS.ResultsCompared
tFUS,
was
associated
with
decreased
(pre
post
tFUS)
blood-oxygen-level-dependent
activation
(F(1,25)
=
4.86,
p
0.04,
η2
0.16)
task,
lower
hippocampal
(F(1,27)
4.41,
0.05,
0.14),
dorsal
anterior
cingulate
cortex
6.26,
0.02;
0.19)
The
decrease
correlated
subjective
(r
0.62,
0.03).
There
no
group
effect
SCR
changes
from
pre
(F(1,23)
0.85,
0.37).
showed
amygdala-insula
(F(1,28)
4.98,
0.03)
amygdala-hippocampal
7.14,
0.01)
rsFC,
increased
amygdala-ventromedial
prefrontal
3.52,
0.05)
connectivity.ConclusionstFUS
can
change
connectivity
anxiety.
Future
studies
should
investigate
therapeutic
potential
for
clinical
levels
Biomedical Engineering Letters,
Год журнала:
2024,
Номер
14(3), С. 407 - 438
Опубликована: Март 2, 2024
Transcranial
ultrasonic
neuromodulation
is
a
rapidly
burgeoning
field
where
low-intensity
transcranial
focused
ultrasound
(tFUS),
with
exquisite
spatial
resolution
and
deep
tissue
penetration,
used
to
non-invasively
activate
or
suppress
neural
activity
in
specific
brain
regions.
Over
the
past
decade,
there
has
been
rapid
increase
of
tFUS
studies
healthy
humans
subjects
central
nervous
system
(CNS)
disease
conditions,
including
recent
surge
clinical
investigations
patients.
This
narrative
review
summarized
findings
human
using
either
unfocused
(TUS)
reported
from
2013
2023.
The
were
categorized
into
two
separate
sections:
research
studies.
A
total
42
reviewed
as
grouped
by
targeted
regions,
various
cortical,
subcortical,
areas
thalamus.
For
research,
22
articles
for
each
studied
CNS
condition,
chronic
pain,
disorder
consciousness,
Alzheimer's
disease,
Parkinson's
depression,
schizophrenia,
anxiety
disorders,
substance
use
disorder,
drug-resistant
epilepsy,
stroke.
Detailed
information
on
subjects/cohorts,
target
sonication
parameters,
outcome
readouts,
stimulatory
efficacies
tabulated
study.
In
later
sections,
considerations
planning
also
concisely
discussed.
With
an
excellent
safety
profile
date,
growth
underscores
increasing
interest
recognition
its
significant
potential
non-invasive
stimulation
(NIBS),
offering
theranostic
neurological
psychiatric
conditions
neuroscientific
tools
functional
mapping.
Brain stimulation,
Год журнала:
2024,
Номер
17(4), С. 734 - 751
Опубликована: Июнь 15, 2024
Low-intensity
transcranial
ultrasound
has
surged
forward
as
a
non-invasive
and
disruptive
tool
for
neuromodulation
with
applications
in
basic
neuroscience
research
the
treatment
of
neurological
psychiatric
conditions.
To
provide
comprehensive
overview
update
preclinical
clinical
low
intensity
emphasize
emerging
role
functional
brain
mapping
to
guide,
better
understand,
predict
responses.
A
systematic
review
was
conducted
by
searching
Web
Science
Scopus
databases
studies
on
neuromodulation,
both
humans
animals.
187
relevant
were
identified
reviewed,
including
116
71
reports
subjects
belonging
diverse
cohorts.
Milestones
are
described
within
an
broader
landscape.
General
neural
readouts
outcome
measures
discussed,
potential
confounds
noted,
use
magnetic
resonance
imaging
is
highlighted.
Ultrasound
emerged
powerful
study
treat
range
conditions
its
combination
various
significantly
advanced
this
platform.
In
particular,
yielded
exciting
inferences
into
advance
our
understanding
function,
neuromodulatory
mechanisms,
ultimately
outcomes.
It
anticipated
that
these
trials
first
many;
focused
ultrasound,
particularly
imaging,
enhance
spectrum
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 4, 2025
Introduction
Up
to
50%
of
individuals
fail
respond
current
depression
treatments.
Repetitive
negative
thought
and
default
mode
network
hyperconnectivity
are
central
in
can
potentially
be
targeted
using
novel
neuromodulation
techniques.
This
community-based
study
assessed
whether
a
treatment
non-invasive
transcranial
focused
ultrasound
targeting
the
decrease
symptoms
repetitive
thought,
improve
quality
life.
Methods
Study
recruitment
began
August
2023
ended
February
2024.
Twenty
aged
18
–
50
were
enrolled
from
among
247
screened.
Exclusion
criteria
included
history
psychosis/mania,
acute
suicidality,
MRI
contraindications,
pregnancy,
medical
neurological
factors
that
may
complicate
diagnosis
or
brain
function.
Participants
completed
up
three
weeks
(11
sessions)
anterior
medial
prefrontal
cortex;
ten
minutes
per
session.
Depression
severity
(Beck
Inventory
II
Hamilton
Rating
Scale),
(Perseverative
Thinking
Questionnaire),
life
(World
Health
Organization
Quality
Life
Scale)
outcomes.
Results
sample
was
young
(mean
30.4
years
±
10.0),
predominantly
female
(75%),
with
moderate
severe
high
comorbidity.
Fifty
percent
participants
endorsed
psychiatric
medication
use.
Ten
subjects
dropped
out
due
time
constraints.
Significant
decreases
observed
over
course
on
self-report,
10.9
(p
<
0.001,
CI
=
-13.55,
-7.92)
interview
ratings,
4.2
-5.85,
-2.62),
as
well
significant
8.4
<0.001,
-10.55,
-6.03).
Improvements
physical
psychological
well-being
also
treatment,
7.2
3.64,
10.63)
11.2
7.79,
14.49),
respectively,
improvements
environment
satisfaction,
5.0
=0.001,
2.24,
7.56).
Discussion
Non-invasive
holds
promise
for
depression,
however,
future
work
including
control
arms
is
required
ascertain
its
causal
role
depression.
Clinical
trial
registration
https://clinicaltrials.gov/study/NCT06320028intr=Ultrasound&cond=depression&locStr=Arizona&country=United%20States&state=Arizona&rank=1
,
identifier
NCT06320028.
Current Opinion in Behavioral Sciences,
Год журнала:
2024,
Номер
56, С. 101370 - 101370
Опубликована: Март 8, 2024
The
use
of
'offline'
transcranial
ultrasound
stimulation
(TUS)
protocols
is
particular
interest
in
the
rapidly
growing
field
low-intensity
TUS.
Offline
TUS
can
modulate
neural
activity
up
to
several
hours
after
stimulation,
suggesting
induction
early-phase
neuroplasticity.
Studies
both
humans
and
nonhuman
primates
have
shown
spatially
specific
changes
neuromodulation
target
a
distributed
network
regions
associated
with
it.
These
suggest
that
excitatory
or
inhibitory
effects
are
result
complex
interaction
between
protocol
used
underlying
brain
region
state.
Understanding
how
neuroplasticity
induced
by
offline
could
open
avenues
for
influencing
late-phase
therapeutic
applications
wide
range
disorders.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 8, 2024
Abstract
Transcranial
ultrasound
stimulation
(TUS)
has
emerged
as
a
promising
technique
for
non-invasive
neuromodulation,
but
current
systems
lack
the
precision
to
target
deep
brain
structures
effectively.
Here,
we
introduce
an
advanced
TUS
system
that
achieves
unprecedented
in
neuromodulation.
The
features
256-element,
helmet-shaped
transducer
array
operating
at
555
kHz,
coupled
with
stereotactic
positioning
system,
individualised
treatment
planning,
and
real-time
monitoring
using
functional
MRI.
In
series
of
experiments,
demonstrate
system’s
ability
selectively
modulate
activity
lateral
geniculate
nucleus
(LGN)
its
functionally
connected
regions
visual
cortex.
Participants
exhibited
significantly
increased
cortex
during
concurrent
stimulation,
high
reproducibility
across
individuals.
Moreover,
theta-burst
protocol
induced
robust
neuromodulatory
effects,
decreased
observed
least
40
minutes
post-stimulation.
These
effects
were
specific
targeted
LGN,
confirmed
by
control
experiments.
Our
findings
highlight
potential
this
non-invasively
circuits
specificity,
offering
new
avenues
studying
function
developing
therapies
neurological
psychiatric
disorders.
spatial
resolution
prolonged
transformative
technology
both
research
clinical
applications,
paving
way
era
Brain Communications,
Год журнала:
2024,
Номер
6(6)
Опубликована: Янв. 1, 2024
Neuronal
dysfunction
in
specific
brain
regions
or
across
distributed
networks
is
a
known
feature
of
Alzheimer's
disease.
An
often
reported
finding
the
early
stage
disease
presence
increased
functional
MRI
(fMRI)
blood
oxygenation
level-dependent
signal
under
task
conditions
relative
to
cognitively
normal
controls,
phenomenon
as
'hyperactivation'.
However,
research
past
decades
yielded
complex,
sometimes
conflicting
results.
The
magnitude
and
topology
fMRI
hyperactivation
patterns
have
been
found
vary
preclinical
clinical
spectrum
disease,
including
concomitant
'hypoactivation'
some
cases.
These
incongruences
are
likely
due
range
factors,
at
which
cohort
examined,
areas
studied
paradigm
utilized
evoke
these
abnormalities.
Additionally,
perennial
question
pertains
nature
context
Some
propose
it
reflects
compensatory
mechanisms
sustain
cognitive
performance,
while
others
suggest
linked
pathological
disruption
highly
regulated
homeostatic
cycle
that
contributes
to,
even
drives,
progression.
Providing
coherent
narrative
for
empirical
conceptual
discrepancies
paramount
develop
models,
understand
synergy
between
cascade
tailor
effective
interventions.
We
first
provide
comprehensive
overview
changes
spanning
course
from
ageing
then
highlight
evidence
supporting
close
relationship
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 30, 2024
Abstract
Transcranial
focused
ultrasound
stimulation
(tFUS)
has
been
proven
capable
of
altering
focal
neuronal
activities
and
neural
circuits
non-invasively
in
both
animals
humans.
The
abilities
tFUS
for
cell-type
selection
within
the
targeted
area
like
somatosensory
cortex
have
shown
to
be
parameter
related.
However,
how
subpopulations
across
pathways
are
affected,
example
affected
connections
between
brain
areas
remains
unclear.
In
this
study,
multi-site
intracranial
recordings
were
used
quantify
responses
at
(S1),
motor
(M1)
posterior
medial
thalamic
nucleus
(POm)
cortico-thalamo-cortical
(CTC)
pathway.
We
found
that
when
targeting
S1
or
POm,
only
regular
spiking
units
(RSUs,
putative
excitatory
neurons)
responded
specific
parameters
(duty
cycle:
6%-60%
pulse
repetition
frequency:
1500
3000
Hz
)
during
sonication.
RSUs
from
directly
connected
(POm
S1)
showed
a
synchronized
response,
which
changed
directional
correlation
POm
S1.
induced
excitation
activated
feedforward
feedback
loops
thalamus,
eliciting
delayed
fast
(FSUs)
by
affecting
local
network.
Our
findings
indicated
can
modulate
CTC
pathway
through
loops,
could
influence
larger
cortical
including
cortex.
Biological Psychiatry Global Open Science,
Год журнала:
2024,
Номер
4(5), С. 100342 - 100342
Опубликована: Июнь 5, 2024
The
amygdala
is
highly
implicated
in
an
array
of
psychiatric
disorders
but
not
accessible
using
currently
available
non-invasive
neuromodulatory
techniques.
Low-intensity
transcranial
focused
ultrasound
(TFUS)
a
technique
that
capable
reaching
subcortical
regions
non-invasively.
Healthy
older
adult
participants
(n
=
21;
ages
48-79)
received
TFUS
targeting
the
right
and
left
entorhinal
cortex
(active
control
region)
two-visit
within-participant
crossover
design.
Before
after
TFUS,
behavioral
measures
were
collected
via
State-Trait
Anxiety
Inventory
(STAI)
emotional
reactivity
regulation
task
(ERRT)
utilizing
neutral
negatively
valenced
images
from
International
Affective
Pictures
Set
(IAPS).
Heart
rate
self-reported
valence
arousal
measured
during
ERRT
order
to
investigate
subjective
physiological
responses
task.
Significant
increases
both
response
negative
heart
inter-trial
intervals
observed
when
targeted
amygdala;
these
changes
evident
was
targeted.
No
significant
found
for
state
anxiety,
images,
cardiac
or
emotion
regulation.
results
this
study
provide
preliminary
evidence
single
session
may
alter
psychophysiological
responses,
indicating
some
potential
future
neuropsychiatric
applications.
However,
further
work
on
parameters
optimization
necessary
determine
how
elicit
more
clinically
advantageous
direction.