Frontiers in Human Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Дек. 4, 2024
Low-intensity transcranial focused ultrasound (tFUS) is a brain stimulation approach that holds promise for the treatment of brain-based disorders. Studies in humans have shown tFUS can successfully modulate perfusion focal sonication targets, including amygdala; however, limited research has explored how impacts large-scale neural networks.
Язык: Английский
Neuromodulation Technology at the Neural Interface, Год журнала: 2024, Номер unknown
Опубликована: Апрель 1, 2024
Язык: Английский
Процитировано
2
Frontiers in Psychiatry, Год журнала: 2024, Номер 15
Опубликована: Ноя. 19, 2024
Substance use disorder (SUD) is a persistent public health issue that necessitates the exploration of novel therapeutic interventions. Low-intensity focused ultrasound (LIFU) promising modality for precise and invasive modulation brain activity, capable redefining landscape SUD treatment. The review overviews effective LIFU neuromodulatory parameters molecular mechanisms, focusing on reward pathways in key regions animal human models. Integration with established therapeutics holds promise augmenting treatment outcomes SUD. current research examines LIFU's efficacy reducing cravings withdrawal symptoms. shows cravings, modulating circuitry, addressing interoceptive dysregulation emotional distress. Selecting optimal parameters, encompassing frequency, burst patterns, intensity, pivotal balancing safety. However, inconsistencies empirical findings warrant further physiological action long-term effects. Collaborative interdisciplinary investigations are imperative to fully realize potential revolutionizing paradigms enhancing patient outcomes.
Язык: Английский
Процитировано
2
Опубликована: Дек. 6, 2024
Low-intensity Transcranial Ultrasound Stimulation (TUS) is a promising non-invasive technique for deep-brain stimulation and focal neuromodulation. Research with animal models computational modelling has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first conduct systematic review of human studies perturbing function alleviating brain disorders. We then collate set hypotheses on directionality effects an initial meta-analysis study reported outcomes to date ( n = 32 studies, 37 experiments). find parameters such as duty cycle show some predictability regarding whether targeted area’s likely enhanced suppressed. Given sample sizes are exponentially increasing, recognize results stabilize change further reported. Therefore, conclude by establishing Iowa-Newcastle (inTUS) resource reporting support hypothesis testing greater precision in neuromodulation TUS.
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 27, 2024
Abstract Background Low-intensity transcranial focused ultrasound (tFUS) is a brain stimulation approach that holds immense promise for the treatment of brain-based disorders. Several studies in humans have shown tFUS can successfully modulate perfusion focal sonication targets including amygdala; however, limited research has explored how impacts function large-scale neural networks. Objective The aim current study was to address this gap and examine changes resting-state connectivity between network nodes using randomized, double-blind, within-subject crossover design. Methods Healthy adults (n=18) completed two sessions, 14 days apart. Each session included either right amygdala or left entorhinal cortex (ErC). inclusion active allowed within-subjects comparisons as locus sonication. Resting-state functional magnetic resonance imaging collected before after each session. Results altered (rsFC) within rs-network nodes. Specifically, pre-to-post modulated salience (SAN) SAN default-mode (DMN) fronto-parietal (FRP). A decrease FPN specific target. Pre-to-post ErC found dorsal attention (DAN) DMN. An increase DAN DMN Conclusion These preliminary findings may suggest induces neuroplastic beyond immediate
Язык: Английский
Процитировано
0
Frontiers in Human Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Дек. 4, 2024
Low-intensity transcranial focused ultrasound (tFUS) is a brain stimulation approach that holds promise for the treatment of brain-based disorders. Studies in humans have shown tFUS can successfully modulate perfusion focal sonication targets, including amygdala; however, limited research has explored how impacts large-scale neural networks.
Язык: Английский
Процитировано
0