Journal of Neurology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Multiple
sclerosis
(MS)
is
a
demyelinating
neurological
disorder
with
highly
heterogeneous
clinical
presentation
and
course
of
progression.
Disease-modifying
therapies
are
the
only
available
treatment,
as
there
no
known
cure
for
disease.
Careful
selection
suitable
necessary,
they
can
be
accompanied
by
serious
risks
adverse
effects
such
infection.
Magnetic
resonance
imaging
(MRI)
plays
central
role
in
diagnosis
management
MS,
though
MRI
lesions
have
displayed
moderate
associations
MS
outcomes,
clinico-radiological
paradox.
With
advent
machine
learning
(ML)
healthcare,
predictive
power
improved
leveraging
both
traditional
advanced
ML
algorithms
capable
analyzing
increasingly
complex
patterns
within
neuroimaging
data.
The
purpose
this
review
was
to
examine
application
MRI-based
prediction
disease
Studies
were
divided
into
five
main
categories:
predicting
conversion
clinically
isolated
syndrome
cognitive
outcome,
EDSS-related
disability,
motor
disability
activity.
performance
models
discussed
along
highlighting
influential
MRI-derived
biomarkers.
Overall,
presents
promising
avenue
prognosis.
However,
integration
biomarkers
other
multimodal
patient
data
shows
great
potential
advancing
personalized
healthcare
approaches
MS.
Neurobiology of Disease,
Год журнала:
2023,
Номер
183, С. 106174 - 106174
Опубликована: Июнь 5, 2023
Neuroinflammation
is
involved
in
the
pathophysiology
of
Alzheimer's
disease
(AD),
including
immune-linked
genetic
variants
and
molecular
pathways,
microglia
astrocytes.
Multiple
Sclerosis
(MS)
a
chronic,
immune-mediated
with
environmental
risk
factors
neuropathological
features.
There
are
clinical
pathobiological
similarities
between
AD
MS.
Here,
we
investigated
shared
susceptibility
MS
to
identify
putative
pathological
mechanisms
neurodegeneration
immune
system.
We
analysed
GWAS
data
for
late-onset
(N
cases
=
64,549,
N
controls
634,442)
14,802,
26,703).
Gaussian
causal
mixture
modelling
(MiXeR)
was
applied
characterise
architecture
overlap
Local
correlation
Analysis
[co]Variant
Association
(LAVA).
The
conjunctional
false
discovery
rate
(conjFDR)
framework
used
specific
loci,
which
functional
annotation
conducted
FUMA
Open
Targets.
MiXeR
analysis
showed
comparable
polygenicities
(approximately
1800
trait-influencing
variants)
20%
despite
negligible
(rg
0.03),
suggesting
mixed
directions
effects
across
variants.
conjFDR
identified
16
8
having
concordant
direction
Annotated
genes
loci
were
enriched
signalling
pathways
inflammation
structural
organisation
neurons.
Despite
low
global
correlation,
current
results
provide
evidence
polygenic
neurodegeneration,
highlighting
new
opportunities
future
investigation.
European Psychiatry,
Год журнала:
2023,
Номер
66(1)
Опубликована: Янв. 1, 2023
Abstract
The
ongoing
developments
of
psychiatric
classification
systems
have
largely
improved
reliability
diagnosis,
including
that
schizophrenia.
However,
with
an
unknown
pathophysiology
and
lacking
biomarkers,
its
validity
still
remains
low,
requiring
further
advancements.
Research
has
helped
establish
multiple
sclerosis
(MS)
as
the
central
nervous
system
(CNS)
disorder
established
pathophysiology,
defined
biomarkers
therefore
good
significantly
treatment
options.
Before
proposing
next
steps
in
research
aim
to
improve
diagnostic
process
schizophrenia,
it
is
imperative
recognize
clinical
heterogeneity.
Indeed,
individuals
schizophrenia
show
high
interindividual
variability
terms
symptomatic
manifestation,
response
treatment,
course
illness
functional
outcomes.
There
also
a
multiplicity
risk
factors
contribute
development
Moreover,
accumulating
evidence
indicates
several
dimensions
psychopathology
cross
current
categorizations.
Schizophrenia
shares
number
similarities
MS,
which
demyelinating
disease
CNS.
These
appear
context
age
onset,
geographical
distribution,
involvement
immune-inflammatory
processes,
neurocognitive
impairment
various
trajectories
course.
This
article
provides
critical
appraisal
taking
into
consideration
advancements
been
made
diagnosis
management
MS.
Based
on
comparison
between
two
disorders,
key
directions
for
studies
are
formulated.
All
them
converge
necessity
deconstruct
psychosis
spectrum
adopt
dimensional
approaches
deep
phenotyping
refine
boundaries.
Patient Preference and Adherence,
Год журнала:
2024,
Номер
Volume 18, С. 455 - 466
Опубликована: Фев. 1, 2024
Background:
To
reduce
the
risk
of
long-term
disability
in
people
with
Multiple
Sclerosis
(pwMS),
an
increasing
number
diseasemodifying
immune
therapies
(DMT)
are
available,
involving
diverse
mechanisms
action,
levels
efficacy,
treatment
risks,
and
tolerability
aspects.Including
patient
preferences
expectations
shared
decision-making
may
improve
satisfaction,
adherence,
persistence.Purpose:
investigate
alignment
individual
pwMS
their
actual
DMT
its
effect
on
health-related
quality
life
(HRQoL),
discontinuation.Methods:
A
total
401
beginning
a
new
were
enrolled
from
2015
to
2018
non-interventional
study
at
three
German
MS
centres.Patient
regarding
DMT,
TSQM-9,
SF36,
self-reported
adherence
as
well
relapses
EDSS
recorded
baseline
every
3
6
months
for
up
years.Results:
Efficacy
highest-ranking
baseline.Actual
selection
corresponded
more
closely
safety
than
tolerability,
or
convenience
preferences.Participants
reported
excellent
throughout
study.DMT
persistence
was
69.0%,
earlier
discontinuation
injectable
vs
oral
infusion
therapies.Breakthrough
disease,
rather
patient-reported
outcomes,
main
driver
discontinuation.For
all
routes
administration,
global
satisfaction
increased
over
time
despite
lower
convenience.Several
patterns
changing
observed.
Conclusion:This
provides
insight
into
interaction
experience.Treatment
decisions
should
be
aligned
promote
continuous
adherence.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(7), С. 2003 - 2003
Опубликована: Март 29, 2024
Multiple
sclerosis
(MS)
is
the
most
common
cause
of
non-traumatic
long-term
disability
in
young
adults.
Whole-body
cryostimulation
(WBC)
a
cold-based
physical
therapy
known
to
induce
physiological
exercise-mimicking
changes
cardiovascular,
neuromuscular,
immune,
and
endocrine
systems
influence
functional
psychological
parameters
by
exposing
human
body
cryogenic
temperatures
(≤−110
°C)
for
2–3
min.
The
purpose
this
scoping
review
present
an
overall
view
on
potential
role
WBC
as
adjuvant
treatment
MS.
PubMed,
ScienceDirect,
Embase,
Web
Science
were
searched
up
30
November
2023,
total
13
articles
included.
may
have
beneficial
antioxidant
effects
short-term
There
no
significant
enzymes,
nitric
oxide
levels,
metalloproteinase
blood
counts,
rheology,
biochemistry.
can
lead
reduction
fatigue
improvement
status,
with
effect
both
mental
well-being.
reported
adverse
effects.
results
suggest
that
complement
therapeutic
options
patients
MS,
cold
stimulation
been
shown
activate
processes
improve
mood,
anxiety,
fatigue.
American Journal of Physical Medicine & Rehabilitation,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 1, 2024
Abstract
Objective
To
estimate
the
current
nationwide
prevalence
of
falls,
injurious
concerns
about
falling,
and
information
on
fall
prevention
among
people
with
multiple
sclerosis
(PwMS).
Design
This
is
a
cross-sectional
national
web-based
survey
that
included
965
adult
PwMS.
Participants
self-reported
falls
experienced
in
past
6
months.
also
provided
their
falling
received.
Results
A
total
56%
reported
The
at
population
level
ranges
between
53%
59%.
Most
occur
inside
participants’
homes
(68%).
About
30%
fallers
an
fall.
respondents,
87%
expressed
being
concerned
68%
they
had
cut
down
activities
due
to
falling.
Among
participants
who
received
(64%),
only
9%
formal
course.
Conclusion
Despite
advances
research
over
last
decades,
continues
be
highly
prevalent
problem
for
one-third
those
result
injuries.
Concerns
non-fallers
affect
performance
daily
independence.
Few
receive
education
or
training.
Biomedicines,
Год журнала:
2022,
Номер
10(12), С. 3000 - 3000
Опубликована: Ноя. 22, 2022
Some
of
the
most
prevalent
neurodegenerative
disorders,
including
Alzheimer’s
and
Parkinson’s
disease,
are
proteinopathies
characterized
by
accumulation
specific
protein
aggregates
in
brain.
Such
misfolded
can
trigger
modulation
innate
adaptive
immune
systems
subsequently
lead
to
chronic
neuroinflammation
that
drives
onset
progression
diseases.
Since
there
is
still
no
effective
disease-modifying
treatment,
new
therapeutic
targets
for
have
been
sought.
The
endocannabinoid
system,
particular
cannabinoid
CB2
receptors,
extensively
studied,
due
their
important
role
neuroinflammation,
especially
microglial
cells.
Several
studies
shown
promising
effects
receptor
activation
on
reducing
aggregation-based
pathology
as
well
attenuating
inflammation
several
dementia-related
symptoms.
In
this
review,
we
discuss
available
data
receptors
potential
benefits
limitations
agonists
these
therapy
proteinopathies.
