Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Июль 16, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is the most common disorder worldwide, with an estimated global prevalence of more than 31%. steatohepatitis (MASH), formerly (NASH), a progressive form MASLD characterized by hepatic steatosis, inflammation, and fibrosis. This review aims to provide comprehensive analysis extrahepatic manifestations MASH, focusing on chronic diseases related cardiovascular, muscular, renal systems. A systematic published studies literature was conducted summarize findings systemic impacts MASH. The focused association MASH metabolic comorbidities, cardiovascular mortality, sarcopenia, kidney disease. Mechanistic insights into concept lipotoxic inflammatory "spill over" from MASH-affected were also explored. are highly associated (50%-80%) other comorbidities such impaired insulin response, type 2 diabetes, dyslipidemia, hypertriglyceridemia, hypertension. Furthermore, 90% obese patients diabetes have Data suggest that in middle-aged individuals (especially those aged 45-54), independent risk factor for plays crucial role mediating pathological effects observed. Understanding multifaceted impact heart, muscle, early detection stratification. knowledge timely implementing management strategies addressing multi-organ involvement pathogenesis.

Язык: Английский

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Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 3010 - 3010

Опубликована: Март 5, 2024

This systematic review addresses the use of Lactiplantibacillus (Lactobacillus) plantarum in symptomatological intervention neurodegenerative disease. The existence gut microbiota dysbiosis has been associated with systemic inflammatory processes present disease, creating opportunity for new treatment strategies. involves modifying strains that constitute to enhance synaptic function through gut–brain axis. Recent studies have evaluated beneficial effects on motor and cognitive symptomatology, alone or combination. includes 20 research articles (n = 3 human n 17 animal models). main result this was combination produced improvements symptomatology related However, one included reported negative after administration plantarum. provides current relevant information about probiotic pathologies such as Alzheimer’s Parkinson’s disease Multiple Sclerosis.

Язык: Английский

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Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals

Advances in Nutrition, Год журнала: 2025, Номер unknown, С. 100376 - 100376

Опубликована: Янв. 1, 2025

Aging is associated with the decline of tissue and cellular functions, which can promote development age-related diseases like cancer, cardiovascular disease, neurodegeneration, disorders musculoskeletal immune systems. Healthspan length time an individual in good health free from chronic disabilities aging. Two modifiable factors that influence healthspan, healthy aging, prevent diseases, are diet microbiota gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals gut work concert to a First overview provided influences aging through its impact on barrier integrity, function, mitochondria function oxidative stress. Next, mechanisms by effect health, inflammation, nurture diverse microbial composition discussed. Lastly, directly producing bioactive metabolites food urolithin A, equol, hesperetin sulforaphane. These other phytochemical derived may healthspan Importantly, individual's capacity produce promoting cruciferous vegetables, berries, nuts, citrus soy products be dependent specific bacteria present gut.

Язык: Английский

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Understanding of Alzheimer's Disease Pathophysiology for Therapeutic Implications of Natural Products as Neuroprotective Agents

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102680 - 102680

Опубликована: Фев. 1, 2025

Язык: Английский

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Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117277 - 117277

Опубликована: Авг. 9, 2024

Язык: Английский

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Rapid Biodistribution of Fluorescent Outer-Membrane Vesicles from the Intestine to Distant Organs via the Blood in Mice

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1821 - 1821

Опубликована: Фев. 2, 2024

A cell's ability to secrete extracellular vesicles (EVs) for communication is present in all three domains of life. Notably, Gram-negative bacteria produce a specific type EVs called outer membrane (OMVs). We previously observed the presence OMVs human blood, which could represent means from microbiota host. Here, order investigate possible translocation intestine other organs, mouse was used as an animal model after administration. To achieve this, we first optimized signal containing fluorescent protein miRFP713 associated with anchoring peptide OmpA by adding biliverdin, fluorescence cofactor, cultures. The miRFP713-expressing produced E. coli REL606 strain were then characterized according their diameter and composition. Native- found homogenous populations vesicles. Finally, vivo ex imaging monitor distribution miRFP713-OMVs mice various organs whether intravenous injection or oral gavage. relative stability signals up 3 days post-injection/gavage paves way future studies investigating OMV-based established between different microbiotas

Язык: Английский

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The bilateral cross communication in microbiota-gut-brain axis as a promising therapeutic target for Alzheimer’s disease: a focus on neuroinflammation

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Фев. 11, 2025

Abstract The microbiota- gut-brain interaction is a fundamental aspect of the synergy between microbiota and host in accessing signaling pathways to modulate brain function behavior. bilateral cross-communication, which might be direct or indirect, within line axis becoming promising therapeutic target for central nervous system (CNS) disorders, including Alzheimer’s disease (AD). Dysbiosis creates an imbalance abundance pro-inflammatory anti-inflammatory species, species’ availability may vary based on type neurodegenerative diseases. final outcome (i.e., dysbiosis) follows similar approach, leading shift towards state gut, increased gut permeability, triggered peripheral inflammatory response consequently occurs. To fully exploit impact interventions AD, scientific investigations help understand complex neuroinflammatory mechanisms investigating potential modulating future therapies.

Язык: Английский

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Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Год журнала: 2025, Номер 15(2), С. 270 - 270

Опубликована: Фев. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Язык: Английский

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The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

Microorganisms, Год журнала: 2024, Номер 12(2), С. 238 - 238

Опубликована: Янв. 23, 2024

Gut luminal dysbiosis and pathobiosis result in compositional biodiversified alterations the microbial host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), acquisition new traits can be achieved through exchange mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break harmonized balance intestinal compartment. present objectives are: 1. To reveal role played by GEMs’ transfers changing landscape enteric microbiome eubiosis 2. expand on potential detrimental effects those changes human genome health. A search articles published PubMed/MEDLINE, EMBASE, Scielo from 2000 to August 2023 using appropriate MeSH entry terms was performed. exchanges induce multiple diseases. GEMs change long-term natural pro- or eukaryotic cell inhabitants. worldwide regulatory authority’s safety control not enough protect public Viability, biocontainment, many other aspects are only partially controlled harmful consequences for health should avoided. It important remember that prevention most cost-effective strategy primum non nocere focus.

Язык: Английский

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Psychobiotics and the Microbiota–Gut–Brain Axis: Where Do We Go from Here?

Microorganisms, Год журнала: 2024, Номер 12(4), С. 634 - 634

Опубликована: Март 22, 2024

The bidirectional relationship between the gut microbiota and nervous system is known as microbiota-gut-brain axis (MGBA). MGBA controls complex interactions brain, enteric system, gut-associated immune neuroendocrine systems, regulating key physiological functions such response, sleep, emotions mood, food intake, intestinal functions. Psychobiotics are considered tools with potential to modulate through preventive, adjunctive, or curative approaches, but their specific mechanisms of action on many aspects health yet be characterized. This narrative review perspectives article highlights paradigms needing attention scope probiotics applications in human increases, a growing body evidence supporting systemic beneficial effects. However, there limitations overcome before establishing extent which we can incorporate management neuropsychiatric disorders. Although this uses term general manner, it remains important study at strain level most cases.

Язык: Английский

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