World Journal of Gastrointestinal Surgery,
Год журнала:
2025,
Номер
17(2)
Опубликована: Янв. 20, 2025
Restoring
the
balance
of
gut
microbiota
has
emerged
as
a
critical
strategy
in
treating
intestinal
disorders,
with
probiotics
playing
pivotal
role
maintaining
bacterial
equilibrium.
Surgical
preparations,
trauma,
and
digestive
tract
reconstruction
associated
surgeries
often
disrupt
flora,
prompting
interest
potential
postoperative
recovery.
Lan
et
al
conducted
prospective
randomized
study
on
60
patients
acute
appendicitis,
revealing
that
administration
Bacillus
licheniformis
capsules
facilitated
early
resolution
inflammation
restoration
gastrointestinal
motility,
offering
novel
therapeutic
avenue
for
accelerated
This
editorial
delves
into
effects
perioperative
probiotic
supplementation
physical
recovery
following
surgery.
Within
framework
enhanced
after
surgery,
exploration
new
strategies
to
mitigate
surgical
complications
reshape
is
particularly
intriguing.
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Microorganisms,
Год журнала:
2023,
Номер
11(9), С. 2160 - 2160
Опубликована: Авг. 26, 2023
The
fine
balance
between
symbiotic
and
potentially
opportunistic
and/or
pathogenic
microorganisms
can
undergo
quantitative
alterations,
which,
when
associated
with
low
intestinal
biodiversity,
could
be
responsible
for
the
development
of
gut
inflammation
so-called
“intestinal
dysbiosis”.
This
condition
is
characterized
by
disbalance
a
synergistic
mechanism
involving
mucosal
barrier,
neuroendocrine
system,
immune
system
that
results
in
an
acute
inflammatory
response
induced
different
causes,
including
viral
or
bacterial
infections
digestive
tract.
More
frequently,
however,
dysbiosis
slowly
subtly
subliminal
causal
factors,
resulting
chronic
related
to
diseases
affecting
tract
other
organs
apparatuses.
Studies
on
animal
models,
together
studies
humans,
highlight
significant
role
microbiota
microbiome
occurrence
conditions
such
as
metabolic
syndrome
cardiovascular
(CVDs);
neurodegenerative,
urologic,
skin,
liver,
kidney
pathologies;
premature
aging.
blood
translocation
fragments
has
been
found
one
processes
linked
possible
“metabolic
endotoxemia”
systemic
inflammation,
increased
risk
oxidative
stress
diseases.
In
this
context,
supplementation
probiotic
strains
shown
restore
eubiosis,
especially
if
administered
long-term
treatments.
aim
review
describe
anti-inflammatory
effects
specific
observed
clinical
trials
respective
indications,
highlighting
differences
efficacy
depending
strain,
formulation,
time
duration
treatment,
dosage
used.
Journal of Toxicology and Environmental Health,
Год журнала:
2024,
Номер
87(11), С. 471 - 479
Опубликована: Апрель 9, 2024
Cannabidiol
(CBD),
a
natural
component
extracted
from
Cannabis
sativa
L.
exerts
neuroprotective,
antioxidant,
and
anti-inflammatory
effects
in
Alzheimer's
disease
(AD),
characterized
by
impaired
cognition
accumulation
of
amyloid-B
peptides
(Aβ).
Interactions
between
the
gut
central
nervous
system
(microbiota-gut-brain
axis)
play
critical
role
pathogenesis
neurodegenerative
disorder
AD.
At
present
investigations
into
mechanisms
underlying
neuroprotective
action
CBD
AD
are
not
conclusive.
The
aim
this
study
was
thus
to
examine
influence
on
involvement
microbiota-gut-brain
axis
using
senescence-accelerated
mouse
prone
8
(SAMP8)
model.
Data
demonstrated
that
administration
SAMP8
mice
improved
cognitive
function
as
evidenced
Morris
water
maze
test
increased
hippocampal
activated
microglia
shift
M1
M2.
In
addition,
elevated
levels
Bacteriodetes
associated
with
fall
Firmicutes
providing
morphologically
protective
intestinal
barrier
which
subsequently
reduced
leakage
toxic
metabolites.
Further,
found
reduce
colon
epithelial
cells
lipopolysaccharide
(LPS),
known
be
leading
gastrointestinal
motility,
thereby
promoting
neuroinflammation
subsequent
neuronal
death.
Our
findings
may
considered
beneficial
therapeutic
drug
counteract
AD-mediated
impairment
restore
microbial
functions
observed
mechanisms.
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1027 - 1027
Опубликована: Фев. 24, 2025
Vitamin
K
is
essential
for
many
physiological
processes,
including
coagulation,
bone
metabolism,
tissue
calcification,
and
antioxidant
activity.
vitamers
are
represented
by
lipophilic
compounds
with
similar
chemical
structure
(i.e.,
phylloquinone
(vitamin
K1)
menaquinone
K2)).
deficiency
can
affect
coagulation
vascular
increasing
the
risk
of
hemorrhages,
atherosclerosis,
cerebrovascular
diseases,
neurodegeneration.
Recently,
several
studies
have
hypothesized
a
possible
dual
role
vitamin
in
benefiting
both
cerebral
health,
e.g.,
sphingolipids
biosynthesis
or
ferroptosis
inhibition.
The
aim
this
narrative
review
to
deepen
understanding
biological
activities
its
protective/preventive
actions
neurovascular
degenerative
conditions,
stroke
dementia.
Given
difficulties
related
hemorrhagic
entailed
prevention
strokes,
function
antagonists
also
investigated.
Finally,
we
track
development
clinical
concept
future
preventive
strategy
innovative
use
as
supplement
counteract
pathological
focusing
particular
on
World Journal of Experimental Medicine,
Год журнала:
2025,
Номер
15(2)
Опубликована: Апрель 11, 2025
BACKGROUND
Malnutrition
and
epilepsy
share
a
complex
bidirectional
relationship,
with
malnutrition
serving
as
potential
risk
factor
for
development,
while
epilepsy,
in
turn,
often
exerts
profound
effects
on
nutritional
status.
Nutritional
interventions
have
emerged
critical
adjunctive
approach
management.
AIM
To
explore
the
multifaceted
associations
between
structured
into
three
primary
sections:
(1)
Elucidating
impact
of
onset;
(2)
Examining
reciprocal
influence
status,
(3)
Evaluating
diverse
management
epilepsy.
METHODS
A
systematic
search
was
conducted
across
PubMed,
Scopus,
Web
Science
databases
utilizing
defined
keywords
related
to
malnutrition,
interventions.
Inclusion
criteria
encompassed
various
study
types,
including
clinical
trials,
animal
models,
cohort
studies,
case
reports,
meta-analyses,
reviews,
guidelines,
editorials,
review
articles.
Four
hundred
sixteen
pertinent
references
were
identified,
198
articles,
153
research
21
24
14
4
2
editorials
meeting
predefined
criteria.
RESULTS
The
revealed
intricate
interplay
highlighting
development
elucidating
how
leads
deficiencies.
Findings
underscored
importance
managing
showing
their
seizure
frequency,
neuronal
function,
overall
brain
health.
CONCLUSION
This
emphasizes
relationship
emphasizing
role
treatment.
insights
underscore
need
holistic
addressing
aspects
alongside
conventional
strategies.
Gut
luminal
dysbiosis
and
pathobiosis
result
in
compositional
biodiversify
alterations
the
microbial
host
co-metabolites.
The
main
mechanism
of
bacterial
evolution
is
horizontal
gene
transfer
(HGT)
acquisition
new
traits
can
be
achieved
through
mobile
genetic
element
(MGEs)
exchange.
Introducing
genetically
engineered
microbes
(GEMs)
might
break
harmonized
balance
intestinal
compartment.
present
objectives
are:
1.
To
reveal
role
played
by
GEMs'
transfers
changing
landscape
enteric
microbiome
eubiosis
2.
expand
on
potential
detrimental
effects
those
changes
human
genome
health.
A
search
articles
published
PubMed/MEDLINE,
EMBASE,
Scielo
from
2000
to
august
2023,
using
appropriate
MeSH
entry
terms
were
performed.
exchanges
induce
multiple
diseases.
GEMs
change
long-term
natural
pro-
or
eukaryotic
cells
inhabitants.
worldwide
regulatory
authority's
safety
control
not
enough
protect
public
Viability
biocontainment
many
other
aspects
are
only
partially
controlled
harmful
consequences
for
health
should
avoided.
Always
remember
that
prevention
most
cost-
effective
strategy
"primum
non
nocere"
name
game.
